Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1

This review provides a summary of recent discoveries in choline transport and the proteins mediating it with a specific focus on the choline transporter-like proteins (CTL)/solute carriers 44 A (SLC44A) and their role in phospholipid metabolism. Since its initial cloning, particularly, the CTL1/SLC44A1 transporter has been investigated further and its ubiquitous expression characterized in various cells and tissues of mouse, rat, and human origin. We describe the role of this choline transporter both in the plasma membrane and in the mitochondria and summarize novel aspects of choline transport regulation in the muscle, nervous system, and cancer. Impact statement This review will provide a summary of recent advances in choline transport research and highlight important novel areas of focus in the field.

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Reexamining the Role of Choline Transporter-Like (Ctlp) Proteins in Choline Transport

Neurochemical Research ◽

10.1023/b:nere.0000013752.43906.e5 ◽

2004 ◽

Vol 29 (2) ◽

pp. 461-467 ◽

Cited By ~ 15

Author(s):

Rachel Zufferey ◽

Teresa C. Santiago ◽

Valerie Brachet ◽

Choukri Ben Mamoun

Keyword(s):

Choline Transport ◽

Choline Transporter

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Tau in Oligodendrocytes Takes Neurons in Sickness and in Health

International Journal of Molecular Sciences ◽

10.3390/ijms19082408 ◽

2018 ◽

Vol 19 (8) ◽

pp. 2408 ◽

Cited By ~ 9

Author(s):

Patrizia LoPresti

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Crucial Role ◽

Brain Health ◽

Protein Tau ◽

Cellular Processes ◽

Transport Regulation ◽

The Central Nervous System ◽

Review Current

Oligodendrocytes (OLGs), the myelin-forming cells of the central nervous system (CNS), are lifelong partners of neurons. They adjust to the functional demands of neurons over the course of a lifetime to meet the functional needs of a healthy CNS. When this functional interplay breaks down, CNS degeneration follows. OLG processes are essential features for OLGs being able to connect with the neurons. As many as fifty cellular processes from a single OLG reach and wrap an equal number of axonal segments. The cellular processes extend to meet and wrap axonal segments with myelin. Further, transport regulation, which is critical for myelination, takes place within the cellular processes. Because the microtubule-associated protein tau plays a crucial role in cellular process extension and myelination, alterations of tau in OLGs have deleterious effects, resulting in neuronal malfunction and CNS degeneration. Here, we review current concepts on the lifelong role of OLGs and myelin for brain health and plasticity. We present key studies of tau in OLGs and select important studies of tau in neurons. The extensive work on tau in neurons has considerably advanced our understanding of how tau promotes either health or disease. Because OLGs are crucial to neuronal health at any age, an understanding of the functions and regulation of tau in OLGs could uncover new therapeutics for selective CNS neurodegenerative diseases.

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The role of prostaglandin receptors in mediating stress response in the central nervous system

Neuroscience Research ◽

10.1016/s0168-0102(00)81006-8 ◽

2000 ◽

Vol 38 ◽

pp. S26

Author(s):

Y Matsuoka

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Stress Response ◽

Prostaglandin Receptors ◽

The Central Nervous System

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The role of the sympathetic and sensory nervous system in peritoneal endometriotic lesions

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0031-1292700 ◽

2011 ◽

Vol 71 (10) ◽

Author(s):

J Arnold ◽

ML Barcena de Arellano ◽

C Rüster ◽

A Schneider ◽

S Mechsner

Keyword(s):

Nervous System ◽

Sensory Nervous System

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Thyroid hormone-catecholamine interrelationships during exposure to cold

Acta Endocrinologica ◽

10.1530/acta.0.0970091 ◽

1981 ◽

Vol 97 (1) ◽

pp. 91-97 ◽

Cited By ~ 21

Author(s):

H. Storm ◽

C. van Hardeveld ◽

A. A. H. Kassenaar

Keyword(s):

Nervous System ◽

Plasma Concentration ◽

Thyroid Hormone ◽

Sympathetic Nervous System ◽

Plasma Levels ◽

Surgical Procedure ◽

Exposure To Cold ◽

Basal Plasma ◽

Sympathetic Nervous

Abstract. Basal plasma levels for adrenalin (A), noradrenalin (NA), l-triiodothyronine (T3), and l-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4°C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4°C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23°C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.

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