scholarly journals Systemic Antibiotics and Tooth Loss in Periodontal Disease

2008 ◽  
Vol 87 (9) ◽  
pp. 871-876 ◽  
Author(s):  
J. Cunha-Cruz ◽  
P.P. Hujoel ◽  
G. Maupome ◽  
B. Saver
Keyword(s):  
Periodontal Disease ◽  
Tooth Loss ◽  
Randomized Trials ◽  
Severe Disease ◽  
Antibiotic Use ◽  
Subgroup Analyses ◽  
Adjusted Rate ◽  
Systemic Antibiotics ◽  
Adjusted Rate Ratio

Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1–13 days, 14–20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8–1.1; RR = 1.2; 95% CI = 0.9–1.4, and RR =1.2, 95% CI =1.0–1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.

scholarly journals Periodontitis subject with failing dentition and management with cross arch bridge and implants

2016 ◽  
Vol 2 (3) ◽  
pp. 58
Author(s):  
Farhan Durrani
Keyword(s):  
Periodontal Disease ◽  
Tooth Loss ◽  
Disease Recurrence ◽  
Prosthetic Rehabilitation ◽  
Long Term Follow Up ◽  
Full Mouth Rehabilitation ◽  
Severe Periodontal Disease ◽  
Arch Bridges

<p class="abstract"><span lang="EN-US">Severe periodontal disease often leads to tooth loss, necessitating prosthetic rehabilitation to restore function and aesthetics. The concept of perio-prosthetic treatment using extensive bridges of cross-arch design was introduced approximately 30 years ago. Long term follow-up studies have shown that teeth with reduced periodontal support can be used as abutments for extensive fixed prostheses, provided periodontal disease had been treated successfully and an effective recall program had been instituted to prevent periodontal disease recurrence. Implants along with cross arch bridges in controlled periodontitis subject have never been used together for complete full mouth rehabilitation.</span></p>

scholarly journals Levels of Cadmium in Human Mandibular Bone

Toxics ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 31
Author(s):  
Andrew W. Browar ◽  
Landon L. Leavitt ◽  
Walter C. Prozialeck ◽  
Joshua R. Edwards
Keyword(s):  
Periodontal Disease ◽  
Tooth Loss ◽  
Alveolar Bone ◽  
Kidney Cortex ◽  
Tissue Destruction ◽  
Mandibular Bone ◽  
Cd Accumulation ◽  
Basal Bone ◽  
Human Cadavers

Cadmium (Cd) is an environmental toxicant that accumulates in bone and alters bone turnover and metabolism. Periodontal disease is characterized by tooth loss and tissue destruction, specifically, loss of supporting bone around the teeth. We have previously shown that Cd causes loss of dental alveolar (tooth supporting) bone in a rodent model of long-term Cd poisoning. The overall goal of this study was to determine the possible association between levels of Cd in alveolar bone and evidence of periodontal disease in human cadavers. The extent of Cd accumulation in human mandible samples was analyzed. Levels of Cd in mandibular alveolar bone were compared to those in basal bone as well as the renal cortex in samples obtained from the cadavers. Alveolar bone contained significantly higher levels of Cd when compared to basal bone (p < 0.01). Cd levels in mandibular bone were significantly higher in female compared to male cadavers (p < 0.05). The kidney cortex had greater than 15-fold higher Cd levels compared to mandible bone. Additional analyses showed a possible association between levels of Cd in basal bone and the presence of periodontal disease in cadavers from which the samples were obtained. This study shows that Cd accumulates to relatively high levels within alveolar bone as compared to basal bone in the mandible and thus may have a significant and direct effect in the progression of changes in bone associated with periodontal disease.

scholarly journals Systematic Review of the Literature on Dental Caries and Periodontal Disease in Socio-Economically Disadvantaged Individuals

2021 ◽  
Vol 18 (23) ◽  
pp. 12360
Author(s):  
Stefano Cianetti ◽  
Chiara Valenti ◽  
Massimiliano Orso ◽  
Giuseppe Lomurno ◽  
Michele Nardone ◽  
...  
Keyword(s):  
Dental Caries ◽  
Periodontal Disease ◽  
Economically Disadvantaged ◽  
Tooth Loss ◽  
Severe Disease ◽  
Oral Disease ◽  
Tooth Decay ◽  
Oral Diseases ◽  
Policy Makers ◽  
Socially Disadvantaged

Dental caries and periodontal disease represent a health problem and a social cost for the entire population, and in particular for socio-economically disadvantaged individuals who are less resistant to disease. The aim of this review is to estimate the prevalence and severity of the two dental pathologies, caries and periodontal disease, in the different classes of socio-economically disadvantaged subjects and to understand which of them are most affected. A systematic search of the literature was performed in MEDLINE (via PubMed), EMBASE and Web of Science after establishing a suitable search strategy for each database, using keywords related to socio-economically vulnerable classes and health outcomes. Socio-economically disadvantaged individuals are more susceptible to tooth decay and periodontal disease (with relative tooth loss) than non-vulnerable people. Additionally, when multiple vulnerabilities are combined in the same subject, these oral diseases worsen. There is no type of vulnerability more affected by caries and periodontitis than others, since overall they all have severe disease indices. The data from this systematic literature review might be useful for health policy makers looking to allocate more resources and services to socially disadvantaged individuals, resulting in making them more resilient to oral disease due to their social marginalization.

Parental separation at birth and depression in adulthood: a long-term follow-up of the Finnish Christmas Seal Home Children

2004 ◽  
Vol 34 (2) ◽  
pp. 357-362 ◽  
Author(s):  
J. VEIJOLA ◽  
P. MÄKI ◽  
M. JOUKAMAA ◽  
E. LÄÄRÄ ◽  
H. HAKKO ◽  
...  
Keyword(s):  
Temporal Separation ◽  
Early Separation ◽  
The Family ◽  
Long Term Follow Up ◽  
Birth Data ◽  
Adjusted Rate ◽  
Matching Criteria ◽  
Adjusted Rate Ratio

Background. Early separation of a child from the mother has been considered a risk factor for later depression. We investigated the association between very early separation and depression in adulthood in a unique dataset.Method. The index cohort consisted of 3020 subjects born in 1945–1965 in Finland, isolated from their family due to tuberculosis in the family and placed in special nurseries, immediately after birth, for an average time of 7 months. Those subjects alive at 1 January, 1971 were identified. For every index subject two reference subjects were chosen, the matching criteria being sex, year of birth and place of birth. Data on depression were obtained from the Finnish Hospital Discharge Register by the end of year 1998.Results. In males, 4·2% of the index subjects and 2·6% (Adjusted Rate Ratio RR 1·7, 95% CI 1·3–2·3) of the reference subjects had been treated in hospital due to a depressive episode. In females the respective figures were 3·9% for index subjects and 3·6% (RR 1·1, 95% CI 0·8–1·5) for reference subjects.Conclusions. The index subjects had an elevated risk for hospital treated depression in adulthood. One explanation may be that the very early temporal separation from the mother at birth may have unfavourable effects on later psychological development. On the other hand, separation from the parents at birth was not found to be strongly associated with severe adulthood depression.

Efficacy of odanacatib in postmenopausal women with osteoporosis: subgroup analyses of data from the phase 3 long-term odanacatib fracture trial (LOFT)

2016 ◽  
Author(s):  
Kenneth G Saag ◽  
Peter Alexandersen ◽  
Claude-Laurent Benhamou ◽  
Nigel Gilchrist ◽  
Johan Halse ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Phase 3 ◽  
Subgroup Analyses

Infections and use of antibiotics in residents of long-term care facilities in Hungary

2014 ◽  
Vol 155 (23) ◽  
pp. 911-917 ◽  
Author(s):  
Rita Szabó ◽  
Karolina Böröcz
Keyword(s):  
Urinary Tract ◽  
Long Term Care ◽  
Soft Tissues ◽  
Good Practice ◽  
Antibiotic Use ◽  
Prevalence Survey ◽  
Term Care ◽  
Care Facilities ◽  
Tract Infections

Introduction: Healthcare associated infections and antimicrobial use are common among residents of long-term care facilities. Faced to the lack of standardized data, the European Centre for Disease Prevention and Control funded a project with the aim of estimating prevalence of infections and antibiotic use in European long-term care facilities. Aim: The aim of the authors was to present the results of the European survey which were obtained in Hungary. Method: In Hungary, 91 long-term care facilities with 11,823 residents participated in the point-prevalence survey in May, 2013. Results: The prevalence of infections was 2.1%. Skin and soft tissues infections were the most frequent (36%), followed by infections of the respiratory (30%) and urinary tract (21%). Antimicrobials were mostly prescribed for urinary tract infections (40.3%), respiratory tract infections (38.4%) and skin and soft tissue infections (13.2%). The most common antimicrobials (97.5%) belonged to the ATC J01 class of “antibacterials for systemic use”. Conclusions: The results emphasise the need for a national guideline and education for good practice in long-term care facilities. Orv. Hetil., 2014, 155(23), 911–917.

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