The Influence of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor on Stroke Recovery Outcome: A Systematic Review and Meta-analysis

2021 ◽  
pp. 154596832110141
Author(s):  
Xuan Liu ◽  
Jun-Chao Fang ◽  
Xin-Yue Zhi ◽  
Qiu-Yu Yan ◽  
Hong Zhu ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Genetic Model ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Recessive Model ◽  
Stroke Recovery ◽  
Stroke Severity ◽  
Val66met Polymorphism ◽  
Asian Patients ◽  
Caucasian Patients

Background and purpose. A single nucleotide polymorphism at nucleotide 196 (G/A) in the human brain-derived neurotrophic factor ( BDNF) gene produces an amino acid substitution (valine to methionine) at codon 66(Val66Met). It is unclear whether carriers of this substitution may have worse functional outcomes after stroke. We aimed to explore the distribution of Val66Met polymorphism and evaluate the effect of different genotypes on stroke functional recovery. Methods. Several databases were searched using the keywords BDNF or brain-derived neurotrophic factor, codon66, G196A, rs6265, or Val66Met, and stroke. Results. A total of 25 articles were relevant to estimate the distribution of alleles; 5 reports were applied in the meta-analysis to assess genetic differences on recovery outcomes. The genetic model analysis showed that the recessive model should be used; we combined data for AA versus GA+GG (GG—Val/Val, GA—Val/Met, AA—Met/Met). The results showed that stroke patients with AA might have worse recovery outcomes than those with GA+GG (odds ratio = 1.90; 95% CI: 1.17-3.10; P = .010; I2 = 69.2%). Overall, the A allele may be more common in Asian patients (48.6%; 95% CI: 45.8%-51.4%, I2 = 54.2%) than Caucasian patients (29.8%; 95% CI: 7.5%-52.1%; I2 = 99.1%). However, in Caucasian patients, the frequency of the A allele in Iranians (87.9%; 95% CI: 83.4%-92.3%) was quite higher than that in other Caucasians (18.7%; 95% CI: 16.6%-20.9%; I2 = 0.00%). Conclusion. Val66Met AA carriers may have worse rehabilitation outcomes than GA+GG carriers. Further studies are needed to determine the effect of Val66Met polymorphism on stroke recovery and to evaluate this relationship with ethnicity, sex, age, stroke type, observe duration, stroke severity, injury location, and therapies.

scholarly journals Association Between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Methamphetamine Use Disorder: A Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Li He ◽  
Yanhui Liao ◽  
Qiuxia Wu ◽  
Tieqiao Liu
Keyword(s):  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Current Data ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Val66met Polymorphism ◽  
Asian Populations ◽  
Bdnf Val66met Polymorphism ◽  
Relationship Of

Background: Several studies had examined the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and methamphetamine (METH) use disorder, whereas the results were conflicting. The aim of this study was to conduct a meta-analysis to achieve a pooled effect size of the association between BDNF Val66Met polymorphism and METH use disorder.Methods: Literature searches were conducted in PubMed, EMBASE, and Cochrane Library up to July, 2020. All relevant studies on the relationship of BDNF Val66Met polymorphism and METH addiction were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated in the dominant, recessive, co-dominant, and allele model to appraise the association.Results: Seven case–control studies with a total of 2,204 subjects (956 METH-dependent cases and 1,248 healthy controls) were included in this meta-analysis. The results showed a significant correlation between BDNF Val66Met polymorphism and METH dependence in overall population under different genetic models. However, subgroup analysis indicated that the association only existed in Han Chinese but not in other Asian populations.Conclusion: Although the current data indicate that BDNF Val66Met polymorphism might be a potential genetic factor for METH use disorder, more researches are needed to prove its role in different populations.

Is the Val66Met polymorphism of the brain-derived neurotrophic factor gene associated with panic disorder? A meta-analysis

2015 ◽  
Vol 9 (2) ◽  
pp. e12228 ◽  
Author(s):  
Kaiyuan Chen ◽  
Na Wang ◽  
Jie Zhang ◽  
Xiaohong Hong ◽  
Haiyun Xu ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Factor Gene ◽  
The Brain

scholarly journals Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Nathan T. Lee ◽  
Fatimah Ahmedy ◽  
Natiara Mohamad Hashim ◽  
Khin Nyein Yin ◽  
Kai Ling Chin
Keyword(s):  
Neurotrophic Factor ◽  
Selection Process ◽  
Brain Derived Neurotrophic Factor ◽  
Stroke Recovery ◽  
Bdnf Gene ◽  
Eligibility Criteria ◽  
Val66met Polymorphism ◽  
Language Interventions ◽  
Causes Of Mortality ◽  
Aphasia Recovery

Stroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. This review assesses the recent evidence on the association between the BDNF polymorphism and aphasia recovery in poststroke patients. The article highlights BNDF polymorphism characteristics, speech and language interventions delivered, and the influence of BNDF polymorphism on poststroke aphasia recovery. We conducted a literature search through PubMed and Google Scholar with the following terms: “brain derived-neurotrophic factor” and “aphasia” for original articles from January 2000 until June 2020. Out of 69 search results, a detailed selection process produced a total of 3 articles that met the eligibility criteria. All three studies included Val66Met polymorphism as the studied human BDNF gene. One of the studies demonstrated insufficient evidence to conclude that BDNF polymorphism plays a role in poststroke aphasia recovery. The remaining two studies have shown that Met allele genotype (either single or double nucleotides) was associated with poor aphasia recovery, in either acute or chronic stroke. Carriers of the Val66Met polymorphism of BDNF gave a poorer response to aphasia intervention and presented with more severe aphasia.

scholarly journals Symptom Dimensions and Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Obsessive-compulsive Disorder

2020 ◽  
Vol 6 (2) ◽  
pp. 84-93
Author(s):  
Shahrzad Hoveyda ◽  
◽  
Javad Khalatbari ◽  
Javid Peymani ◽  
Hasan Ahadi ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Recessive Model ◽  
Obsessive Compulsive ◽  
Val66met Polymorphism ◽  
Symptom Dimensions ◽  
Compulsive Disorder ◽  
Diagnostic And Statistical Manual ◽  
Bdnf Val66met Polymorphism

Background: Obsessive-Compulsive Disorder (OCD) is a serious neuropsychiatric disorder. The clinical prominence of the OCD symptoms dimensions and Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism are of significant importance. Objectives: The present study aimed to investigate the symptom dimensions and BDNF val66Met polymorphism genotype in Iranian patients with OCD. Materials and Methods: A total of 83 patients diagnosed with OCD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM5) criteria, and 83 matched controls were included this case-control study. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to investigate symptom dimensions. In addition, BDNF val66Met polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCRRFLP) method. Results: The obtained data indicated that the most prevalent obsession was contamination (62.6%) and the most prevalent compulsion was cleanliness (69.8%). Furthermore, there was a significant relationship between the genotypes of BDNF val66Met polymorphism in OCD (P<0.01). Besides, carrying the” T” allele confers increased the risk for the presence of OCD [χ2=4.7, P=0.003; OR (95%) 1.93 (1.24-2.99)]. Conclusion: The symptoms dimensions of OCD in the Iranian sample were similar to other populations. Moreover, the findings suggested an association between BDNF val66Met polymorphism genotype and OCD in the explored Iranian sample. The inheritance hypothesis for the TT genotype was the recessive model.

Sign in / Sign up

Export Citation Format

Share Document