Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

Tumours involving Pacinian corpuscles are rare. The literature identifies two main pathological disorders: the Pacinian corpuscle neuroma or hyperplasia and the Pacinian corpuscle neurofibroma. Published data are confusing and at times conflicting. This systematic review summarizes the available data in order to support clinicians in the differential diagnosis with other tumours responsible for unclear symptoms in the hands and fingers. We identified 67 pertinent articles. Although some similarities have been described, the two tumours have relevant differences, specifically when comparing age of the patient, location, symptoms, characteristic of a mass, and aetiology. All these factors should be taken into account in order to improve diagnostic accuracy. Despite the low incidence of unsuccessful surgeries, extraordinary measures are occasionally necessary to achieve complete resolution of symptoms.

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PAX2 in endometrial carcinogenesis and in differential diagnosis of endometrial hyperplasia: A systematic review and meta-analysis of diagnostic accuracy

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/aogs.13512 ◽

2019 ◽

Vol 98 (3) ◽

pp. 287-299 ◽

Cited By ~ 26

Author(s):

Antonio Raffone ◽

Antonio Travaglino ◽

Gabriele Saccone ◽

Massimo Mascolo ◽

Luigi Insabato ◽

...

Keyword(s):

Systematic Review ◽

Differential Diagnosis ◽

Diagnostic Accuracy ◽

Endometrial Hyperplasia ◽

Meta Analysis

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Can physical testing be used to distinguish between migraine and cervicogenic headache sufferers? A protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2019-031587 ◽

2019 ◽

Vol 9 (11) ◽

pp. e031587 ◽

Cited By ~ 1

Author(s):

Ernesto Anarte ◽

Gabriela Ferreira Carvalho ◽

Annika Schwarz ◽

Kerstin Luedtke ◽

Deborah Falla

Keyword(s):

Systematic Review ◽

Differential Diagnosis ◽

Diagnostic Accuracy ◽

Meta Analysis ◽

Cervicogenic Headache ◽

Ethical Approval ◽

Black Scale ◽

Physical Tests ◽

Meta Analyses ◽

Asymptomatic Subjects

IntroductionDifferential diagnosis of migraine and cervicogenic headache (CGH) can be challenging given the large overlap of symptoms, commonly leading to misdiagnosis and ineffective treatment. In order to strengthen the differential diagnosis of headache, previous studies have evaluated the utility of physical tests to examine for musculoskeletal impairment, mainly in the cervical spine, which could be provoking or triggering headache. However, no systematic review has attempted to evaluate whether physical tests can differentiate CGH from migraine or both conditions from asymptomatic subjects.Methods/analysisA systematic review protocol has been designed and is reported in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). A sensitive topic-based search strategy is planned which will include databases, hand searching of key journals and consultation of relevant leading authors in this field. Terms and keywords will be selected after discussion and agreement. Two independent reviewers will perform the search and select studies according to inclusion and exclusion criteria, including any cohort or observational studies evaluating the topic of this review; a third reviewer will confirm accuracy. A narrative synthesis will be developed for all included studies and, if possible, a meta-analysis will be conducted. The overall quality of the evidence will be assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist for diagnostic accuracy studies and the Downs and Black scale for those studies where the QUADAS-2 checklist cannot be applied.Ethics and disseminationEthical approval is not required since no patient information will be collected. The results will provide a deeper understanding about the possibility of using physical tests to differentiate cervicogenic headache from migraine and from asymptomatic subjects, which has direct relevance for clinicians managing people with headache. The results will be published in a peer-reviewed journal and presented at scientific conferences.PROSPERO registration numberCRD42019135269.

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Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review

Diagnostic Pathology ◽

10.1186/s13000-019-0924-z ◽

2020 ◽

Vol 15 (1) ◽

Cited By ~ 3

Author(s):

Yanli Zhu ◽

Yuntao Song ◽

Guohui Xu ◽

Zhihui Fan ◽

Wenhao Ren

Keyword(s):

Systematic Review ◽

Diagnostic Accuracy ◽

Predictive Value ◽

False Positive ◽

False Negative ◽

Diagnostic Errors ◽

Published Data ◽

Cystic Lesions ◽

Adenomatous Hyperplasia ◽

Sensitivity Specificity

Abstract Objective FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed in our institution, assess the cytomorphologic features that contribute to diagnostic errors and propose improvement measures. Methods A total of 2781 FNACs were included in the study, and 1122 cases were compared with their histological diagnoses. We retrospectively reexamined our discordant (both false-negative and false-positive) cases and performed a systematic review of previous studies on causes of misdiagnoses. Results When DC V and DC VI were both considered cytologic-positive, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were 98.3, 30.9, 94.9, 58.3 and 93.5%, respectively. If DC VI was considered cytologic-positive, the sensitivity, specificity, PPV, NPV and diagnostic accuracy of FNAC were 98.0, 84.0, 99.4, 58.3, and 97.5% respectively. The main cause of false-negative diagnoses was sampling error (13/15, 86.7%), while interpretation error led to the majority of the false-positive diagnoses (38/47, 80.9%). Overlapping cytological features in adenomatous hyperplasia, thyroiditis and cystic lesions were the major factors contributing to interpretation errors, while the size and number of nodules may have led to false-negative diagnoses because of heterogeneity and unsampled areas. Conclusions The sensitivity and PPV of thyroid FNAC in our institution were higher than those in the published data, while the specificity and NPV were lower. Regarding the FNA category DC V, a frozen section analysis during diagnostic lobectomy is necessary. Multiple passes should be performed in various parts of a large nodule or from different nodules to reduce the risk of false-negative findings. Cytopathologists should strengthen their criteria for the identification of adenomatous hyperplasia, thyroiditis and cystic lesions to avoid false-positive diagnoses. NIFTP has little effect on diagnostic accuracy and the distribution of diagnostic errors.

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PAINFUL HETEROTOPIC PACINIAN CORPUSCLE IN THE HAND: A REPORT OF THREE CASES

Hand Surgery ◽

10.1142/s0218810411005114 ◽

2011 ◽

Vol 16 (01) ◽

pp. 81-85 ◽

Cited By ~ 6

Author(s):

Hiroki Irie ◽

Teiji Kato ◽

Toshitake Yakushiji ◽

Jun Hirose ◽

Hiroshi Mizuta

Keyword(s):

Differential Diagnosis ◽

Soft Tissue ◽

Severe Pain ◽

Rare Condition ◽

Pacinian Corpuscle ◽

Glomus Tumour ◽

Soft Tissue Tumour ◽

Pacinian Corpuscles ◽

Histopathological Findings ◽

Tissue Tumour

Severe pain in the finger caused by an abnormal Pacinian corpuscle is a rare condition. We have recently encountered three patients diagnosed with a heterotopic Pacinian corpuscle, based on histopathological findings. When making a differential diagnosis of unexplained severe pain in the finger, abnormal Pacinian corpuscles must be taken into account in addition to glomus tumour and other types of painful soft-tissue tumour.

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