Basic science approaches to common hand surgery problems

2021 ◽  
pp. 175319342110426
Author(s):  
Jason Wong ◽  
Matthew Murphy ◽  
Ya Fang Wu ◽  
Ralph Murphy ◽  
Florian S. Frueh ◽  
...  
Keyword(s):  
Basic Science ◽  
Tissue Repair ◽  
Surgical Care ◽  
Hand Surgery ◽  
Clinical Treatment ◽  
Active Living ◽  
Major Improvement ◽  
Critical Issues

The field of hand surgery is constantly evolving to meet challenges of populations with increasing age and higher demands for active living. While our surgical care has improved over the last decades, it seems that future major improvement in outcomes of clinical treatment will come through advances in biologics and the translation of major discoveries in basic science. This article aims to provide an update on where basic science solutions may answer some of the most critical issues in hand surgery, with a focus on augmentation of tissue repair.

scholarly journals Prediction and Analysis of Key Genes in Glioblastoma Based on Bioinformatics

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Hao Long ◽  
Chaofeng Liang ◽  
Xi’an Zhang ◽  
Luxiong Fang ◽  
Gang Wang ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Prediction Model ◽  
Basic Science ◽  
Prediction Accuracy ◽  
Genetic Basis ◽  
Bioinformatics Analysis ◽  
Clinical Treatment ◽  
Structural Level ◽  
Biotechnological Application ◽  
Key Genes

Understanding the mechanisms of glioblastoma at the molecular and structural level is not only interesting for basic science but also valuable for biotechnological application, such as the clinical treatment. In the present study, bioinformatics analysis was performed to reveal and identify the key genes of glioblastoma multiforme (GBM). The results obtained in the present study signified the importance of some genes, such as COL3A1, FN1, and MMP9, for glioblastoma. Based on the selected genes, a prediction model was built, which achieved 94.4% prediction accuracy. These findings might provide more insights into the genetic basis of glioblastoma.

scholarly journals Central Nerve Protection: How We Can Translate the Seeds of Basic Science to Clinical Treatment from Bench to Bed

2009 ◽  
Vol 29 (4) ◽  
pp. 385-405 ◽  
Author(s):  
Hiroyuki UCHINO ◽  
Hidekimi FUKUI ◽  
Masashi NOGUCHI ◽  
Ryouichi MIYASHITA ◽  
Akiko TAKEDA ◽  
...  
Keyword(s):  
Basic Science ◽  
Clinical Treatment

Telephone Clinic Follow-Up Following Carpal Tunnel Decompression

2008 ◽  
Vol 33 (5) ◽  
pp. 641-644 ◽  
Author(s):  
M. WILLIAMS ◽  
A. AMIN ◽  
A. GETGOOD ◽  
P. HALLAM ◽  
A. J. CHOJNOWSKI ◽  
...  
Keyword(s):  
Cost Analysis ◽  
Carpal Tunnel ◽  
Surgical Outcome ◽  
Surgical Care ◽  
Hand Surgery ◽  
Satisfaction Level ◽  
Potential Saving ◽  
Outpatient Consultation ◽  
Effective Cost

This paper investigates the feasibility of a telephone clinic follow-up service for patients undergoing carpal tunnel decompression. Six hundred and thirty patients were recruited over a 2-year period and we assessed their outcome and satisfaction level in the service, using a pre-determined questionnaire 6 weeks following surgery. The telephone clinic was overseen by a surgical care practitioner. We followed up 598 patients (93%) in total, and found 42 patients to be dissatisfied with the service (7%). These patients were referred for outpatient consultation and investigation. Most patients were satisfied with their surgical outcome and found the telephone clinic service to be convenient and effective. Cost analysis calculations estimated a potential saving of £45,958 over the 2-year period when compared to standard outpatient consultation. This model has been developed in our trust to follow up patients undergoing similar minor hand surgery.

Cognition in schizophrenia: from basic science to clinical treatment

2003 ◽  
Vol 169 (3-4) ◽  
pp. 213-214 ◽  
Author(s):  
Philip D. Harvey ◽  
Mark A. Geyer ◽  
Trevor W. Robbins ◽  
John H. Krystal
Keyword(s):  
Basic Science ◽  
Clinical Treatment

4-dimensional, high-resolution imaging of living cells

1992 ◽  
Vol 50 (1) ◽  
pp. 416-417
Author(s):  
Shinya Inoué
Keyword(s):  
Light Microscope ◽  
Living Cells ◽  
Live Cells ◽  
Video Tape ◽  
Active Living ◽  
High Resolution Imaging ◽  
3 Dimensional ◽  
Dynamic Architecture ◽  
Resolution Imaging ◽  
Disk Memory

This paper reports progress of our effort to rapidly capture, and display in time-lapsed mode, the 3-dimensional dynamic architecture of active living cells and developing embryos at the highest resolution of the light microscope. Our approach entails: (A) real-time video tape recording of through-focal, ultrathin optical sections of live cells at the highest resolution of the light microscope; (B) repeat of A at time-lapsed intervals; (C) once each time-lapsed interval, an image at home focus is recorded onto Optical Disk Memory Recorder (OMDR); (D) periods of interest are selected using the OMDR and video tape records; (E) selected stacks of optical sections are converted into plane projections representing different view angles (±4 degrees for stereo view, additional angles when revolving stereos are desired); (F) analysis using A - D.

Principle and practice of high-resolution imaging with a field-emission TEM

1992 ◽  
Vol 50 (1) ◽  
pp. 138-139
Author(s):  
Max T. Otten ◽  
Wim M.J. Coene
Keyword(s):  
High Resolution ◽  
Field Emission ◽  
Incidence Angle ◽  
Temporal Coherence ◽  
Energy Spread ◽  
High Resolution Imaging ◽  
Major Improvement ◽  
High Resolution Images ◽  
Resolution Imaging

High-resolution imaging with a LaB6 instrument is limited by the spatial and temporal coherence, with little contrast remaining beyond the point resolution. A Field Emission Gun (FEG) reduces the incidence angle by a factor 5 to 10 and the energy spread by 2 to 3. Since the incidence angle is the dominant limitation for LaB6 the FEG provides a major improvement in contrast transfer, reducing the information limit to roughly one half of the point resolution. The strong improvement, predicted from high-resolution theory, can be seen readily in diffractograms (Fig. 1) and high-resolution images (Fig. 2). Even if the information in the image is limited deliberately to the point resolution by using an objective aperture, the improved contrast transfer close to the point resolution (Fig. 1) is already worthwhile.

A case study of a nontraditional basic science curriculum

1982 ◽  
Vol 46 (6) ◽  
pp. 314-322
Author(s):  
GI Roth ◽  
RB Bridges ◽  
AT Brown ◽  
R Calmes ◽  
TT Lillich ◽  
...  
Keyword(s):  
Basic Science ◽  
Science Curriculum ◽  
Basic Science Curriculum
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