scholarly journals Pain perception in healthy volunteers: effect of repeated exposure to experimental systemic inflammation

2016 ◽  
Vol 22 (7) ◽  
pp. 546-556 ◽  
Author(s):  
Susanne Janum ◽  
Signe T Nielsen ◽  
Mads U Werner ◽  
Jesper Mehlsen ◽  
Henrik Kehlet ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Systemic Inflammation ◽  
Pain Perception ◽  
Nicotine Patch ◽  
Cytokine Release ◽  
Healthy Human ◽  
Pressure Threshold ◽  
Transdermal Nicotine ◽  
Pain Pressure Threshold ◽  
Increasing Temperature

We aimed to study the relationship between pain perception and cytokine release during systemic inflammation. We present a randomized crossover trial in healthy volunteers ( n = 17) in 37 individual trials. Systemic inflammation was induced by an i.v. bolus of Escherichia coli LPS (2 ng/kg) on two separate trial days, with or without a nicotine patch applied 10 h previously. Pain perception at baseline, and 2 and 6 h after LPS was assessed by pressure algometry and tonic heat stimulation at an increasing temperature (45–48℃) during both trials. Compared with baseline, pain pressure threshold was reduced 2 and 6 h after LPS, while heat pain perception was accentuated at all testing temperatures after 2 but not 6 h. The magnitude of changes in pain perception did not correlate to cytokine release. No effect of transdermal nicotine or training status was observed. In conclusion, LPS administration in healthy human volunteers leads to reduction in pain pressure threshold and an increase in pain perception to heat stimuli, supporting a relationship between acute systemic inflammation and pain perception.

Pain Pressure Threshold in Cluster Headache Patients

Cephalalgia ◽  
1996 ◽  
Vol 16 (1) ◽  
pp. 62-66 ◽  
Author(s):  
G Bono ◽  
F Antonaci ◽  
G Sandrini ◽  
E Pucci ◽  
G Nappi ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Pain Perception ◽  
Perception Threshold ◽  
Temporal Muscle ◽  
Mean Values ◽  
Pressure Threshold ◽  
Pain Pressure Threshold ◽  
Pressure Algometer ◽  
Symmetrical Points ◽  
Symptomatic Side

Pain perception threshold (PFT) in the head was assessed with a pressure algometer in 58 cluster headache (CH) patients (52M, 6F; 41 episodic and 17 chronic). Fourteen patients in cluster period were retested in remission. Thresholds were assessed at 10 symmetrical points on each side of the head and at the deltoid. Compared with controls ( n = 80), CH patients had lower PPT in the head and in the deltoid. PPT was lower on the symptomatic side than on the non-symptomatic side in patients with episodic CH during a cluster period ( p<0.001) and in patients with chronic CH ( p<0.05). This pattern was more evident during a cluster period than during remission ( p<0.05). A reduced PPT did not correlate with illness duration and pain side. The lowest PPT mean values were found at the anterior and intermediate levels of the temporal muscle on the symptomatic side. These results imply a central mechanism underlying the pathogenesis of CH.

scholarly journals Effect of Manual Therapy and Splint Therapy in People with Temporomandibular Disorders: A Preliminary Study

2020 ◽  
Vol 9 (8) ◽  
pp. 2411 ◽  
Author(s):  
Gemma Victoria Espí-López ◽  
Anna Arnal-Gómez ◽  
Alba Cuerda del Pino ◽  
José Benavent-Corai ◽  
Pilar Serra-Añó ◽  
...  
Keyword(s):  
Manual Therapy ◽  
Temporomandibular Disorders ◽  
Pain Perception ◽  
Control Group ◽  
Positive Perception ◽  
Positive Effects ◽  
Splint Therapy ◽  
Pressure Threshold ◽  
Pain Pressure Threshold

Background: Isolated manual therapy techniques (MT) have shown beneficial effects in patients with temporomandibular disorders (TMD) but the effect of the combination of such techniques, together with the well-stablished splint therapy (ST) remains to be elucidated. Objective: This study was conducted to ascertain whether a combined program of MT techniques, including intraoral treatment, plus traditional ST improves pain and clinical dysfunction in subjects with TMD. Methods: A preliminary trial was conducted. 16 participants were assigned to either the MT plus ST-Experimental Group (EG, n = 8) or the ST alone—Control Group (CG, n = 8). Forty-five minute sessions of combined MT techniques were performed, once a week for four weeks. Three evaluations were conducted: baseline, post-treatment, and one-month follow-up. Outcome measures were pain perception, pain pressure threshold (PPT), TMD dysfunction, and perception of change after treatment. Results: EG showed significant reduction on pain, higher PPT, significant improvement of dysfunction and significantly positive perception of change after treatment (p < 0.05 all). Additionally, such positive effects were maintained at follow-up with a high treatment effect (R2 explaining 26.6–33.2% of all variables). Conclusion: MT plus ST showed reduction on perceived pain (3 points decrease), higher PPT (of at least 1.0 kg/cm2), improvement of disability caused by pain (4.4 points decrease), and positive perception of change (EG: 50% felt “much improvement”), compared to ST alone.

scholarly journals Roller massage decreases spinal excitability to the soleus

2018 ◽  
Vol 124 (4) ◽  
pp. 950-959 ◽  
Author(s):  
James D. Young ◽  
Alyssa-Joy Spence ◽  
David G. Behm
Keyword(s):  
High Intensity ◽  
Pain Perception ◽  
H Reflex ◽  
Moderate Intensity ◽  
Plantar Flexors ◽  
M Wave ◽  
Neural Modulation ◽  
Pressure Threshold ◽  
Pain Pressure Threshold ◽  
Spinal Excitability

Roller massage (RM) interventions have shown acute increases in range of motion (ROM) and pain pressure threshold (PPT). It is unclear whether the RM-induced increases can be attributed to changes in neural or muscle responses. The purpose of this study was to evaluate the effect of altered afferent input via application of RM on spinal excitability, as measured with the Hoffmann (H-) reflex. A randomized within-subjects design was used. Three 30-s bouts of RM were implemented on a rested, nonexercised, injury-free muscle with 30 s of rest between bouts. The researcher applied RM to the plantar flexors at three intensities of pain: high, moderate, and sham. Measures included normalized M-wave and H-reflex peak-to-peak amplitudes before, during, and up to 3 min postintervention. M-wave and H-reflex measures were highly reliable. RM resulted in significant decreases in soleus H-reflex amplitudes. High-intensity, moderate-intensity, and sham conditions decreased soleus H-reflex amplitudes by 58%, 43%, and 19%, respectively. H-reflexes induced with high-intensity rolling discomfort or pain were significantly lower than moderate and sham conditions. The effects were transient in nature, with an immediate return to baseline following RM. This is the first evidence of RM-induced modulation of spinal excitability. The intensity-dependent response observed indicates that rolling pressure or pain perception may play a role in modulation of the inhibition. Roller massage-induced neural modulation of spinal excitability may explain previously reported increases in ROM and PPT. NEW & NOTEWORTHY Recent evidence indicates that the benefits of foam rolling and roller massage are primarily accrued through neural mechanisms. The present study attempts to determine the neuromuscular response to roller massage interventions. We provide strong evidence of roller massage-induced neural modulation of spinal excitability to the soleus. It is plausible that reflex inhibition may explain subsequent increases in pain pressure threshold.

scholarly journals Pain Pressure Threshold in the Region of the Sacroiliac Joint in Patients Diagnosed with Sacroiliac Joint Pain

2016 ◽  
Vol 3;19 (3;3) ◽  
pp. 147-154 ◽  
Author(s):  
RJH van Leeuwen
Keyword(s):  
Healthy Volunteers ◽  
Sacroiliac Joint ◽  
Joint Pain ◽  
Intraclass Correlation ◽  
Pain Clinic ◽  
Rater Reliability ◽  
Pressure Pain ◽  
Sacroiliac Joint Pain ◽  
Pressure Threshold ◽  
Pain Pressure Threshold

Background: Although the prevalence of sacroiliac joint (SIJ) pain is relatively high (15 – 30%), there is no unambiguous reference standard to diagnose SIJ pain. Pressure tenderness in the SIJ region is used for diagnostic purposes, but the clinimetric properties of this procedure remain to be determined. Objectives: The aim of this study is to determine the reliability of pain pressure threshold (PPT) measurements in the SIJ region and the difference in PPTs in the SIJ region between healthy volunteers and PPTs in patients with SIJ pain. Study Design: Prospective cohort study. Setting: Outpatient pain clinic VU University Medical Center. Methods: Forty-one healthy volunteers and 31 patients diagnosed with SIJ pain were included. PPTs were obtained from 5 measurement points in the region of the SIJ with a pressure pain algometer using a standardized protocol. The inter-rater reliability of this method was calculated by means of the Intraclass Correlation Coefficients (ICC) of individual assessment performed by 2 individual raters of SIJs of healthy volunteers on both sides. PPTs of healthy volunteers were compared to those of the affected side in patients with SIJ pain. Results: PPT measurement showed moderate to good inter-rater reliability (ICC 0.6 – 0.82).The median PPTs of 5 points was comparable for both sides in healthy volunteers (right: 8.5 kg/cm2 [IQR 6.0 – 10.0]; left 8.3 kg/cm2 (5.8 – 10.0]). Median PPTs for the affected sides of patients with SIJ pain were significantly lower compared to the same side of healthy volunteers (right: 2.4 kg/cm2 [IQR 2.2 – 3.2, n = 15]; left: 2.5 kg/cm2 [2.3 – 3.2, n = 16]; P < 0.001 for both sides). Limitations: Only the SIJ on one side of was measured in patients with SIJ pain, where both sides would be desirable. Conclusions: Pressure pain algometry appears to be a reliable method to establish differences in PPTs between healthy volunteers and patients with SIJ pain. The diagnostic accuracy of this test should be investigated further. Key words: Sacroiliac joint pain, pain pressure threshold, pressure algometry

Safety evaluation of an antimalarial herbal product from Andrographis paniculata (AS201-01) in healthy volunteers

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aty Widyawaruyanti ◽  
Arijanto Jonosewojo ◽  
Hilkatul Ilmi ◽  
Lidya Tumewu ◽  
Ario Imandiri ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Healthy Volunteers ◽  
Day Treatment ◽  
Phase 1 ◽  
Andrographis Paniculata ◽  
Control Group ◽  
Healthy Human ◽  
Double Blind ◽  
Random Blood Glucose ◽  
Significant Difference

Abstract Objectives Andrographis paniculata tablets (AS201-01) have previously been shown to have potent bioactivity as an antimalarial and to produce no unwanted side effects in animal models. Here, we present the phase 1 clinical trial conducted to evaluate the safety of AS201-01 tablets in healthy volunteers. Methods The study was a randomized, double-blind controlled cross-over, a placebo-controlled design consisting of a 4-day treatment of AS201-01 tablets. A total of 30 healthy human volunteers (16 males and 14 females) were divided into two groups, and each group was given 4 tablets, twice daily for 4 days. Group 1 received AS201-01, while group 2 received placebo tablets. Volunteers were given a physical examination before the treatment. The effects of AS201-01 on random blood glucose, biochemical, and hematological as well as urine profiles were investigated. Results There were no changes in observed parameters as a result of AS201-01 being administered. Statistical analysis showed no significant difference (p>0.05) between the test and control group regarding hematology profile, biochemical profile, and random blood glucose. Increased appetite and better sleep, which categorized as grade 1 adverse event was reported after treatment with AS201-01 tablet Conclusions The outcome supports our previous observation that the AS201-01 tablet, given twice a day for 4 days, is safe and nontoxic.

scholarly journals Deviations in Circulating TNFαLevels and TNFαProduction by Mononuclear Cells in Healthy Human Populations

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
T. Mózes ◽  
I. Baráth ◽  
K. Gornicsar ◽  
A. Grosz ◽  
Ta. Mózes ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Mononuclear Cells ◽  
Age Groups ◽  
High Serum ◽  
Human Populations ◽  
Healthy Human ◽  
Necrosis Factor Alpha ◽  
Septic Complications ◽  
Enhanced Sensitivity ◽  
Individual Variations

Objectives. Tumor necrosis factor alpha (TNFα) plays a pivotal role in the inflammatory host response. The serum-level of TNFαand the production of TNFαby lympho/monocytes, however, seem to show high individual variations. The goal of the present study was to investigate the variations and inducibility of TNFα-activity in two age-groups of healthy volunteers.Methods. Sixty elderly, healthy volunteers were studied. These persons were free of malignant diseases, and within three months, they did not have any trauma or inflammatory disease and were not taking any steroids or nonsteroid anti-inflammatory drugs. Thirty young volunteers were also included. Blood samples were taken; lympho/monocytes were separated and cultured with or without endotoxin (LPS) stimulation. Serum and culture supernatant TNFαlevels were determined by bioassay using WEHI 164 cells.Results. The results indicated significant individual variations in TNFαlevels of healthy volunteers irrespective of age. Subgroups with low, middle, and high serum TNF-levels were distinguished. In about 50% of volunteers with low serum-TNFαactivity, LPS stimulation failed to increase the TNFαproduction by isolated lympho/monocytes.Conclusion. Our data suggest a chance to select individuals with enhanced sensitivity for septic complications.

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