scholarly journals Granulomatosis with polyangiitis and pregnancy: A case report and review of the literature

2019 ◽  
Vol 13 (2) ◽  
pp. 76-82
Author(s):  
A Daher ◽  
G Sauvetre ◽  
N Girszyn ◽  
E Verspyck ◽  
H Levesque ◽  
...  
Keyword(s):  
Decision Making ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Intravenous Immunoglobulins ◽  
Review Of The Literature ◽  
Healthy Male ◽  
Sudden Loss ◽  
Loss Of Hearing ◽  
In Pregnancy

The association of granulomatosis with polyangiitis and pregnancy is rare and therapeutic options are limited by the risk of teratogenicity and fetotoxicity. There is a paucity of published literature to guide clinical decision-making in these cases. We report the case of a 26-year-old woman with no medical history who presented at 21 weeks of gestation with a bilateral sudden loss of hearing and erosive rhinitis. The diagnosis of granulomatosis with polyangiitis was confirmed radiologically and biologically. Corticosteroids were not enough to stabilize the disease and she received intravenous immunoglobulins with remission. A successful delivery of a healthy male newborn was done at 36 weeks. A review of all published literature on granulomatosis with polyangiitis in pregnancy between 1970 and 2017 is presented. Trial registration: Not applicable.

scholarly journals The PICO strategy for the research question construction and evidence search

2007 ◽  
Vol 15 (3) ◽  
pp. 508-511 ◽  
Author(s):  
Cristina Mamédio da Costa Santos ◽  
Cibele Andrucioli de Mattos Pimenta ◽  
Moacyr Roberto Cuce Nobre
Keyword(s):  
Decision Making ◽  
Clinical Decision Making ◽  
Evidence Based Practice ◽  
Scientific Evidence ◽  
Research Question ◽  
Clinical Decision ◽  
Evidence Based ◽  
Review Of The Literature

Evidence based practice is the use of the best scientific evidence to support the clinical decision making. The identification of the best evidence requires the construction of an appropriate research question and review of the literature. This article describes the use of the PICO strategy for the construction of the research question and bibliographical search.

scholarly journals A review of COVID-19 therapeutics in pregnancy and lactation

2022 ◽  
pp. 1753495X2110562
Author(s):  
Sarah CJ Jorgensen ◽  
Najla Tabbara ◽  
Lisa Burry
Keyword(s):  
Decision Making ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Elevated Risk ◽  
Published Data ◽  
Safety And Efficacy ◽  
Pregnancy And Lactation ◽  
Safety Signals ◽  
In Pregnancy

Pregnant people have an elevated risk of severe COVID-19-related complications compared to their non-pregnant counterparts, underscoring the need for safe and effective therapies. In this review, we summarize published data on COVID-19 therapeutics in pregnancy and lactation to help inform clinical decision-making about their use in this population. Although no serious safety signals have been raised for many agents, data clearly have serious limitations and there are many important knowledge gaps about the safety and efficacy of key therapeutics used for COVID-19. Moving forward, diligent follow-up and documentation of outcomes in pregnant people treated with these agents will be essential to advance our understanding. Greater regulatory push and incentives are needed to ensure studies to obtain pregnancy data are expedited.

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