scholarly journals Radiomics: a novel feature extraction method for brain neuron degeneration disease using 18F-FDG PET imaging and its implementation for Alzheimer’s disease and mild cognitive impairment

2019 ◽  
Vol 12 ◽  
pp. 175628641983868 ◽  
Author(s):  
Yupeng Li ◽  
Jiehui Jiang ◽  
Jiaying Lu ◽  
Juanjuan Jiang ◽  
Huiwei Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Feature Extraction ◽  
Cognitive Impairment ◽  
Fdg Pet ◽  
Classification Accuracy ◽  
Extraction Method ◽  
Feature Extraction Method ◽  
Computer Aided ◽  
Aided Diagnosis

Background: Alzheimer’s disease (AD) is the most common form of progressive and irreversible dementia, and accurate diagnosis of AD at its prodromal stage is clinically important. Currently, computer-aided diagnosis of AD and mild cognitive impairment (MCI) using 18F-fluorodeoxy-glucose positron emission tomography (18F-FDG PET) imaging is usually based on low-level imaging features or deep learning methods, which have difficulties in achieving sufficient classification accuracy or lack clinical significance. This research therefore aimed to implement a new feature extraction method known as radiomics, to improve the classification accuracy and discover high-order features that can reveal pathological information. Methods: In this study, 18F-FDG PET and clinical assessments were collected in a cohort of 422 individuals [including 130 with AD, 130 with MCI, and 162 healthy controls (HCs)] from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and 44 individuals (including 22 with AD, and 22 HCs) from Huashan Hospital, Shanghai, China. First, we performed a group comparison using a two-sample Student’s t test to determine the regions of interest (ROIs) based on 30 AD patients and 30 HCs from ADNI cohorts. Second, based on two time scans of 32 HCs from ADNI cohorts, we used Cronbach’s alpha coefficient for radiomic feature stability analyses. Pearson’s correlation coefficients were regarded as a feature selection criterion, to select effective features associated with the clinical cognitive scale [clinical dementia rating scale in its sum of boxes (CDRSB); Alzheimer’s disease assessment scale (ADAS)] with 500-times cross-validation. Finally, a support vector machine (SVM) was used to test the ability of the radiomic features to classify HCs, MCI and AD patients. Results: As a result, we identified brain regions which were mainly distributed in the temporal, occipital and frontal areas as ROIs. A total of 168 radiomic features of AD were stable (alpha > 0.8). The classification experiment led to maximal accuracies of 91.5%, 83.1% and 85.9% for classifying AD versus HC, MCI versus HCs and AD versus MCI. Conclusion: The research in this paper proved that the novel approach based on high-order radiomic features extracted from 18F-FDG PET brain images that can be used for AD and MCI computer-aided diagnosis.

scholarly journals Personalized Computer-Aided Diagnosis for Mild Cognitive Impairment in Alzheimer’s Disease Based on sMRI and ¹¹C PiB-PET Analysis

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 218982-218996
Author(s):  
Fatma El-Zahraa A. El-Gamal ◽  
Mohammed M. Elmogy ◽  
Ashraf Khalil ◽  
Mohammed Ghazal ◽  
Jawad Yousaf ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Computer Aided Diagnosis ◽  
Computer Aided ◽  
Aided Diagnosis

scholarly journals Multi-atlas label fusion with random local binary pattern features: Application to hippocampus segmentation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hancan Zhu ◽  
Zhenyu Tang ◽  
Hewei Cheng ◽  
Yihong Wu ◽  
Yong Fan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Feature Extraction ◽  
Image Segmentation ◽  
Extraction Method ◽  
Local Binary Pattern ◽  
Manual Segmentation ◽  
Feature Extraction Method ◽  
Label Fusion ◽  
Hippocampus Segmentation

AbstractAutomatic and reliable segmentation of the hippocampus from magnetic resonance (MR) brain images is extremely important in a variety of neuroimage studies. To improve the hippocampus segmentation performance, a local binary pattern based feature extraction method is developed for machine learning based multi-atlas hippocampus segmentation. Under the framework of multi-atlas image segmentation (MAIS), a set of selected atlases are registered to images to be segmented using a non-linear image registration algorithm. The registered atlases are then used as training data to build linear regression models for segmenting the images based on the image features, referred to as random local binary pattern (RLBP), extracted using a novel image feature extraction method. The RLBP based MAIS algorithm has been validated for segmenting hippocampus based on a data set of 135 T1 MR images which are from the Alzheimer’s Disease Neuroimaging Initiative database (adni.loni.usc.edu). By using manual segmentation labels produced by experienced tracers as the standard of truth, six segmentation evaluation metrics were used to evaluate the image segmentation results by comparing automatic segmentation results with the manual segmentation labels. We further computed Cohen’s d effect size to investigate the sensitivity of each segmenting method in detecting volumetric differences of the hippocampus between different groups of subjects. The evaluation results showed that our method was competitive to state-of-the-art label fusion methods in terms of accuracy. Hippocampal volumetric analysis showed that the proposed RLBP method performed well in detecting the volumetric differences of the hippocampus between groups of Alzheimer’s disease patients, mild cognitive impairment subjects, and normal controls. These results have demonstrated that the RLBP based multi-atlas image segmentation method could facilitate efficient and accurate extraction of the hippocampus and may help predict Alzheimer’s disease. The codes of the proposed method is available (https://www.nitrc.org/frs/?group_id=1242).

Computer aided diagnosis of Alzheimer’s disease using component based SVM

2011 ◽  
Vol 11 (2) ◽  
pp. 2376-2382 ◽  
Author(s):  
I.A. Illán ◽  
J.M. Górriz ◽  
M.M. López ◽  
J. Ramírez ◽  
D. Salas-Gonzalez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Computer Aided Diagnosis ◽  
Computer Aided ◽  
Aided Diagnosis

A new combined transient extraction method coupled with WO3 gas sensors for polluting gases classification

Sensor Review ◽  
2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Rabeb Faleh ◽  
Sami Gomri ◽  
Khalifa Aguir ◽  
Abdennaceur Kachouri
Keyword(s):  
Feature Extraction ◽  
Gas Sensors ◽  
Classification Accuracy ◽  
Extraction Method ◽  
Support Vector ◽  
Classification Rate ◽  
Content Type ◽  
Feature Extraction Method ◽  
Combined Features ◽  
Discrimination Capacity

Purpose The purpose of this paper is to deal with the classification improvement of pollutant using WO3 gases sensors. To evaluate the discrimination capacity, some experiments were achieved using three gases: ozone, ethanol, acetone and a mixture of ozone and ethanol via four WO3 sensors. Design/methodology/approach To improve the classification accuracy and enhance selectivity, some combined features that were configured through the principal component analysis were used. First, evaluate the discrimination capacity; some experiments were performed using three gases: ozone, ethanol, acetone and a mixture of ozone and ethanol, via four WO3 sensors. To this end, three features that are derivate, integral and the time corresponding to the peak derivate have been extracted from each transient sensor response according to four WO3 gas sensors used. Then these extracted parameters were used in a combined array. Findings The results show that the proposed feature extraction method could extract robust information. The Extreme Learning Machine (ELM) was used to identify the studied gases. In addition, ELM was compared with the Support Vector Machine (SVM). The experimental results prove the superiority of the combined features method in our E-nose application, as this method achieves the highest classification rate of 90% using the ELM and 93.03% using the SVM based on Radial Basis Kernel Function SVM-RBF. Originality/value Combined features have been configured from transient response to improve the classification accuracy. The achieved results show that the proposed feature extraction method could extract robust information. The ELM and SVM were used to identify the studied gases.

Research on Computer-Aided Diagnosis of Alzheimer’s Disease Based on Heterogeneous Medical Data Fusion

2019 ◽  
Vol 33 (05) ◽  
pp. 1957001
Author(s):  
Yin Dai ◽  
Daoyun Qiu ◽  
Yang Wang ◽  
Sizhe Dong ◽  
Hong-Li Wang
Keyword(s):  
Neural Network ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Convolutional Neural Network ◽  
Effective Means ◽  
Computer Aided Diagnosis ◽  
Test Results ◽  
Back Propagation Algorithm ◽  
Computer Aided ◽  
Aided Diagnosis

Alzheimer’s disease is the third most expensive disease, only after cancer and cardiopathy. It is also the fourth leading cause of death in the elderly after cardiopathy, cancer, and cerebral palsy. The disease lacks specific diagnostic criteria. At present, there is still no definitive and effective means for preclinical diagnosis and treatment. It is the only disease that cannot be prevented and cured among the world’s top ten fatal diseases. It has now been proposed as a global issue. Computer-aided diagnosis of Alzheimer’s disease (AD) is mostly based on images at this stage. This project uses multi-modality imaging MRI/PET combining with clinical scales and uses deep learning-based computer-aided diagnosis to treat AD, improves the comprehensiveness and accuracy of diagnosis. The project uses Bayesian model and convolutional neural network to train experimental data. The experiment uses the improved existing network model, LeNet-5, to design and build a 10-layer convolutional neural network. The network uses a back-propagation algorithm based on a gradient descent strategy to achieve good diagnostic results. Through the calculation of sensitivity, specificity and accuracy, the test results were evaluated, good test results were obtained.

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