scholarly journals Prenylated Flavones from Artocarpus Lanceifolius and their Cytotoxic Properties against P-388 Cells

2009 ◽  
Vol 4 (7) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Iqbal Musthapa ◽  
Jalifah Latip ◽  
Hiromitsu Takayama ◽  
Lia D. Juliawaty ◽  
Euis H. Hakim ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Mass Spectra ◽  
Cytotoxic Effect ◽  
Methanol Extract ◽  
2D Nmr ◽  
Tree Bark ◽  
Prenylated Flavones ◽  
Murine Leukemia

New prenylated flavones, artoindonesianins Z-4 and Z-5, together with four known prenylated flavones, artonin E, 12-hydroxyartonin E, artobiloxanthone, and cycloartobiloxanthone, have been isolated from the methanol extract of the tree bark of Artocarpus lanceifolius. The structures of these compounds were determined on the basis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. The cytotoxic effect of the isolated compounds against murine leukemia P-388 cells is described.

Cytotoxic Chalcones and Flavanones from the Tree Bark of Cryptocarya costata

2006 ◽  
Vol 61 (3-4) ◽  
pp. 184-188 ◽  
Author(s):  
Hanapi Usman ◽  
Euis H. Hakim ◽  
Tjodi Harlim ◽  
Muhammad N. Jalaluddin ◽  
Yana M. Syah ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Methanol Extract ◽  
Tree Bark ◽  
Spectral Evidence ◽  
Murine Leukemia

A new flavanone, 7-hydroxy-5,6-dimethoxyflavanone (1), together with three other flavonoids, didymocarpin (2), 2′,4′-dihydroxy-5′,6′-dimethoxychalcone (3), and isodidymocarpin (4), had been isolated from the methanol extract of the tree bark of Cryptocarya costata. The structures of these compounds were determined based on spectral evidence, including UV, IR, 1-D and 2-D NMR, and mass spectra. Cytotoxic properties of compounds 1-4 were evaluated against murine leukemia P-388 cells. The chalcones 3 and 4 were found to have substantial cytotoxicity with IC50 of 5.7 and 11.1 μᴍ, respectively.

Two Prenylated Flavones from the Tree Bark of Artocarpus lanceifolius

2006 ◽  
Vol 61 (9) ◽  
pp. 1134-1137 ◽  
Author(s):  
Yana M. Syah ◽  
Sjamsul A. Achmad ◽  
Norio Aimi ◽  
Euis H. Hakim ◽  
Lia D. Juliawatya ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Mass Spectra ◽  
Chloroform Extract ◽  
Tree Bark ◽  
Prenylated Flavones

Abstract Two new prenylated flavones, artoindonesianins Z-1 (1) and Z-2 (2), together with two other known prenylated flavones, artobiloxantone (3) and cycloartobiloxanthone (4), had been isolated and identified from the chloroform extract of the tree bark of Artocarpus lanceifolius. The structures of these compounds were determined based on spectroscopic data, including UV, IR, 1-D and 2-D NMR, and mass spectra. The significance of the presence of the isolated compounds to the chemotaxonomy of Artocarpus is briefly discussed.

scholarly journals PEMISAHAN SENYAWA-SENYAWA YANG BERSIFAT SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P388 DARI EKSTRAK METANOL KULIT BATANG DIPTEROCARPUS CONFERTUS SLOOT (DIPTEROCARPACEAE)

Biomedika ◽  
2015 ◽  
Vol 5 (1) ◽  
Author(s):  
. Muhtadi ◽  
Peni Indrayudha
Keyword(s):  
Methanol Extract ◽  
Tree Bark ◽  
Cytotoxic Activities ◽  
Murine Leukemia

Six compounds, KP-1 up to KP-6 were isolated from the methanol extract of the tree bark of Dipterocarpus confertus Sloot (Dipterocarpaceae). The cytotoxic activities of these compounds were evaluated against murine leukemia P388 cells. Result of these examination indicated that KP-2 compound and KP-1 were very active with each IC 50 value of these compounds were 2.25 and 5.1 μg/mL, respectively. While the others were not active against murine leukemia P388 cells.Keywords: Dipterocarpaceae, Dipterocarpus confertus Sloot, isolated compounds, cytotoxic, and leukemia P-388 cell

scholarly journals New Prenylated Dihydrostilbenes from Croton Laevifolius

2007 ◽  
Vol 2 (11) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
Norizan Ahmat ◽  
Ikram M. Said ◽  
Jalifah Latip ◽  
Laily B. Din ◽  
Yana M. Syah ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Methanol Extract ◽  
2D Nmr ◽  
Spectroscopic Evidence

Two prenylated dihydrostilbenes have been isolated from the methanol extract of the flower of Croton laevifolius. The structures of these compounds were assigned as 3,5,3′,4′-tetrahydroxy-2,6,2′-tris(3-methylbut-2-enyl)dihydrostilbene (laevifolin A) and 3,5,3′,4′-tetrahydroxy-2,6,5′-tris(3-methylbut-2-enyl)dihydrostilbene (laevifolin B) based on spectroscopic evidence, including UV, IR, 1D and 2D NMR, and mass spectra. The chemotaxonomic significance of the presence of these dihydrostilbene derivatives is briefly discussed.

Amanicadol, a Pimarane-type Diterpene from Phlomis amanica Vierch.

2006 ◽  
Vol 61 (11) ◽  
pp. 1433-1436 ◽  
Author(s):  
Funda N. Yalçın ◽  
Tayfun Ersöz ◽  
Erdal Bedir ◽  
Ali A. Dönmez ◽  
Michael Stavri ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Acid Ester ◽  
Spectroscopic Data ◽  
Close Agreement ◽  
Methanol Extract ◽  
Chemical Shifts ◽  
Data Interpretation ◽  
2D Nmr ◽  
Conformational Flexibility ◽  
Molecular Modeling Studies

Fractionation of the methanol extract of Phlomis amanica resulted in the isolation of a new pimarane type diterpene, amanicadol (1), together with the known glycosides lamiide, verbascoside (= acteoside), syringaresinol-4-O-β -glucoside, liriodendrin, syringin, and a caffeic acid ester, chlorogenic acid. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Molecular modeling studies on 1 were conducted and showed that it exhibited low conformational flexibility. Additionally, NMR chemical shifts were calculated for 1 in vacuo, and calculated values were in very close agreement with those found experimentally.

scholarly journals Geranylated Flavonols from Macaranga Rhizinoides

2010 ◽  
Vol 5 (8) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Mulyadi Tanjung ◽  
Didin Mujahidin ◽  
Euis H. Hakim ◽  
Ahmad Darmawan ◽  
Yana M. Syah
Keyword(s):  
Phenolic Compound ◽  
Spectroscopic Data ◽  
Methanol Extract ◽  
Flavonol Derivatives ◽  
Murine Leukemia

Two geranylated and methylated flavonol derivatives, macarhizinoidins A (1) and B (2), along with a known phenolic compound methyl 4-isoprenyloxycinnamate (3), have been isolated from the methanol extract of the leaves M. rhizinoides. The structures of these compounds were identified based on their spectroscopic data. On cytotoxic evaluation against murine leukemia P-388 cells, compounds 1-2 showed IC50 values of 11.4 and 13.9 μM, respectively, while compound 3 was inactive.

scholarly journals An α-Sophoradiol Glycoside from the Root Wood of Erythrina senegalensis DC. (Fabaceae) with α-Amylase and α-Glucosidase Inhibitory Potential

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110445
Author(s):  
Cyrille Tchuente Djoko ◽  
Isaac Silvère Gade ◽  
Alex De Theodore Atchade ◽  
Alfred Ngenge Tamfu ◽  
Rodica Mihaela Dinica ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ethyl Acetate ◽  
Spectroscopic Data ◽  
Methanol Extract ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Phytochemical Study ◽  
Inhibitory Potential

Phytochemical study of the roots of Erythrina senegalensis led to the isolation of a new α-sophoradiol glycoside, erythrinoside (1), together with four known compounds, lupeol (2), α-sophoradiol (3), isoneorautenol (4) and D-mannitol (5). The structures of the compounds were elucidated using spectroscopic data including 1D and 2D NMR, mass spectrometry and by comparison made with some data reported previously; the samples (extracts and compounds) were also subjected to antidiabetic assay. Erythrinoside and isoneorautenol exhibited good α-amylase inhibitory potential of 54.6% and 53.3%, respectively, compared to acarbose (72.5%) at 400 µg/mL. With α-glucosidase, all samples showed promising inhibition percentages above 50% at 200 µg/mL. In the α-glucosidase assay, the ethyl acetate extract (65.5%), methanol extract (72.1%), erythrinoside (63.3%) and isoneorautenol (66.0%) had percentage inhibitions closer to that of acarbose (69.0%) at 200 µg/mL. The methanol extract (IC50 = 81.2 ± 0.9 µg/mL) was more active than acarbose (IC50 = 94.5 ± 0.7 µg.mL) in the α-glucosidase assay. The inhibition of α-amylase and α-glucosidase indicates that E. senegalensis extracts and compounds could be used to manage diabetic conditions.

scholarly journals Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD

2019 ◽  
Vol 5 (2) ◽  
pp. 143-148
Author(s):  
Dewa Gede Katja ◽  
Desi Harneti ◽  
Tri Mayanti ◽  
Nurlelasari Nurlelasari ◽  
Rani Maharani ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
2D Nmr ◽  
Leukemia Cells ◽  
Anticancer Compounds ◽  
Cytotoxic Effects ◽  
Cytotoxicity Activity ◽  
Ic50 Values ◽  
Cytotoxic Steroids ◽  
Murine Leukemia ◽  
Tof Ms

In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.

scholarly journals Cytotoxic Activity of Secondary Metabolites from the Bark of Dipterocarpus Confertus Sloot

2013 ◽  
Vol 9 (1) ◽  
pp. 1861-1865 ◽  
Author(s):  
Muhtadi Muhtadi ◽  
Peni Indrayudha ◽  
Agustono Wibowo ◽  
Dr Heng Yen Khong
Keyword(s):  
Secondary Metabolites ◽  
Cinnamic Acid ◽  
Betulinic Acid ◽  
Spectroscopic Data ◽  
Methanol Extract ◽  
Vero Cells ◽  
The Other ◽  
Published Data ◽  
Ic50 Values ◽  
Murine Leukemia

Four compounds, namely β-sitosterol (1), betulinic acid (2), cinnamic acid (3), and α-viniferin (4) have been successfully isolated from the bark methanol extract of Dipterocarpus confertus Sloot. The structures of the isolated compounds have been established on the basis spectroscopic data evidence, and comparison with the published data. In the cytotoxicity study, cinnamic acid (3) and betulinic acid (2) have been found to be very strong active against murine leukemia P388 and vero cells lines with the IC50 values of 2.25 and 5.10 µg/mL, respectively, while the other compounds were not active.

scholarly journals 8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1265
Author(s):  
Feng Ye ◽  
Yanrong Shi ◽  
Shengliang Zhao ◽  
Zhiying Li ◽  
Haoxin Wang ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Mass Spectra ◽  
Inhibitory Concentration ◽  
Bioinformatics Analysis ◽  
2D Nmr ◽  
Amycolatopsis Mediterranei ◽  
Extensive Analysis ◽  
Candidate Target ◽  
Polyketide Chain ◽  
Kg1 Cells

Proansamycin X, a hypothetical earliest macrocyclic precursor in the biosynthesis of rifamycin, had never been isolated and identified. According to bioinformatics analysis, it was proposed that RifT (a putative NADH-dependent dehydrogenase) may be a candidate target responsible for the dehydrogenation of proansamycin X. In this study, the mutant strain Amycolatopsis mediterranei S699 ΔrifT was constructed by deleting the rifT gene. From this strain, eleven 8-deoxy-rifamycin derivatives (1–11) and seven known analogues (12–18) were isolated. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data and high-resolution ESI mass spectra. Compound 1 is a novel amide N-glycoside of seco-rifamycin. Compounds 2 and 3 feature conserved 11,12-seco-rifamycin W skeleton. The diverse post-modifications in the polyketide chain led to the production of 4–11. Compounds 2, 3, 5, 6, 13 and 15 exhibited antibacterial activity against Staphylococcus aureus (MIC (minimal inhibitory concentration) values of 10, 20, 20, 20, 40 and 20 μg/mL, respectively). Compounds 14, 15, 16, 17 and 18 showed potent antiproliferative activity against KG1 cells with IC50 (half maximal inhibitory concentration) values of 14.91, 44.78, 2.16, 18.67 and 8.07 μM, respectively.

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