Chemical Constituents of Blumea balsamifera of Indonesia and Their Protein Tyrosine Phosphatase 1B Inhibitory Activity
2012 ◽
Vol 7
(7)
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pp. 1934578X1200700
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Keyword(s):
A methanol extract of the leaves of Blumea balsamifera (L.) DC. (Asteraceae) afforded a new guaian-type sesquiterpene, epiblumeaene K (1), together with four known guaian-type sesquiterpenes (2–5), three known sesquiterpenes (6–8), and nine known flavonoids (9–17) by a combination of chromatography and preparative TLC techniques. Their structures were elucidated by extensive spectroscopic methods and comparison with the literature data. Among the isolated compounds, a known sesquiterpene, β-caryophyllene 8 R,9 R-oxide (6), exhibited a significant PTP1B inhibitory activity in a dose-dependent manner, with an IC50 value of 25.8μM (5.62μg/mL).
2016 ◽
Vol 10
(18)
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pp. 242-247
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2014 ◽
Vol 124
(2)
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pp. 276-285
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2018 ◽
Vol 41
◽
pp. 232-239
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2007 ◽
Vol 30
(2)
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pp. 379-381
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2017 ◽
Vol 278
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pp. 65-73
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