ent-Kaurane Diterpenes from Annona glabra and Their Cytotoxic Activities
2014 ◽
Vol 9
(12)
◽
pp. 1934578X1400901
Keyword(s):
2D Nmr
◽
A new ent-kaurane glycoside, annoglabasin H (1), and three known ent-kauranes, annoglabasin E (2), annoglabasin B (3), and 19-nor- ent-kaurent-4-ol-17-oic acid (4) were isolated from the fruits of Annona glabra. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D- and 2D-NMR spectroscopy, as well as by comparison with the NMR data reported in the literature. The cytotoxic activities of these compounds were evaluated on four human cancer cell lines, LU-1, MCF-7, SK-Mel2, and KB. Compound 1 exhibited significant cytotoxic activity on all tested human cancer cell lines with IC50 values ranging from 3.7 to 4.6 μM.
2016 ◽
Vol 17
(1)
◽
pp. 137-142
◽
Keyword(s):
2017 ◽
Vol 12
(10)
◽
pp. 1934578X1701201
◽
Keyword(s):
2013 ◽
Vol 8
(9)
◽
pp. 1934578X1300800
◽
Keyword(s):
2010 ◽
Vol 21
(1)
◽
pp. 38-46
◽
Keyword(s):
Keyword(s):