Two Pyrones with Antibacterial Activities from Alpinia malaccensis

A new pyrone derivative, malakavalactone (2), was isolated from the acetone extract of Alpinia malaccensis fruits, along with a known compound kavalactone (1). The structure of the new compound was determined based on NMR and mass spectral data. Compounds 1 and 2 showed weak antibacterial activities against eight pathogenic bacteria.

Download Full-text

Prenylated 9,10-dihydrophenanthrenes from Macaranga javanica

Zeitschrift für Naturforschung B ◽

10.1515/znb-2015-0062 ◽

2015 ◽

Vol 70 (9) ◽

pp. 659-663 ◽

Cited By ~ 2

Author(s):

Aulia Ilmiawati ◽

Euis H. Hakim ◽

Yana M. Syah

Keyword(s):

Spectral Data ◽

Pathogenic Bacteria ◽

Antibacterial Properties ◽

Acetone Extract ◽

Mass Spectral Data ◽

Mass Spectral ◽

Phytochemical Investigation ◽

First Time

AbstractPhytochemical investigation of the acetone extract of Macaranga javanica leaves afforded three new prenylated 9,10-dihydrophenanthrenes, macajavanicins A–C (1–3). Structures of these compounds were elucidated mainly by NMR and mass spectral data. Along with compounds 1–3, two known prenylated dihydrostilenes, laevifolins A and B (4, 5), were also isolated. The presence of these new 9,10-dihydrophentanthrene derivatives is the first time in the genus Macaranga, and its chemotaxonomic significances are briefly discussed. The antibacterial properties of compounds 1–5 against eight pathogenic bacteria are also described.

Download Full-text

Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa

Zeitschrift für Naturforschung C ◽

10.5560/znc.2014-0066 ◽

2014 ◽

Vol 69 (9-10) ◽

pp. 375-380 ◽

Cited By ~ 12

Author(s):

Muhamad S. Fareza ◽

Yana M. Syah ◽

Didin Mujahidin ◽

Lia D. Juliawaty ◽

Iis Kurniasih

Keyword(s):

Bacillus Subtilis ◽

Spectral Data ◽

Pathogenic Bacteria ◽

Antibacterial Agents ◽

Acetone Extract ◽

Minor Components ◽

Mass Spectral Data ◽

Mass Spectral ◽

Mic Value

Abstract Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A-D (1 - 4), from the acetone extract of the leaves of Macaranga trichocarpa. Reexamination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and found to be mostly moderate antibacterial agents, with the lowest MIC value of 26.5 μM achieved by the flavanone macatrichocarpin A (1) against Bacillus subtilis.

Download Full-text

Antibacterial and antifungal two phenolic sesquiterpenes from Dysoxylum densiflorum

Zeitschrift für Naturforschung C ◽

10.1515/znc-2019-0072 ◽

2020 ◽

Vol 75 (1-2) ◽

pp. 1-5

Author(s):

Ni Komang T. Dharmayani ◽

Tsuyoshi Yoshimura ◽

Elvira Hermawati ◽

Lia D. Juliawaty ◽

Yana M. Syah

Keyword(s):

Pathogenic Bacteria ◽

Antifungal Agents ◽

Inhibitory Concentration ◽

Antibacterial Properties ◽

Acetone Extract ◽

Mass Spectral Data ◽

Mass Spectral ◽

Antifungal Properties ◽

Antibacterial And Antifungal ◽

Dysoxylum Densiflorum

AbstractA new phenolic sesquiterpene, dysoxyphenol (1), and the known sesquiterpene, 7R,10S-2-hydroxycalamenene (2), were isolated from the acetone extract of Dysoxylum densiflorum seeds. The structures of these compounds were determined based on physical, Nuclear Magnetic Resonance, and mass spectral data. Both compounds were evaluated for their antibacterial and antifungal properties against seven pathogenic bacteria and two wood-rotting fungi, respectively. The results showed that both compounds have significant antibacterial properties only against Bacillus subtilis (Minimum Inhibitory Concentration 28 μM), while in the antifungal evaluation compound 1 was found to be more active than compound 2. Therefore, compound 1 has promising antifungal properties that can be developed further for finding new antifungal agents.

Download Full-text

Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin- 3-yl)prop-2-en-1-ones and Their Antimicrobial Activity

Asian Journal of Chemistry ◽

10.14233/ajchem.2019.21968 ◽

2019 ◽

Vol 31 (9) ◽

pp. 1895-1898

Author(s):

Relangi Siva Subrahmanyam ◽

Venkateswara Rao Anna

Keyword(s):

Antimicrobial Activity ◽

Spectral Data ◽

1H Nmr ◽

13C Nmr ◽

Mass Spectral Data ◽

In Vitro Antimicrobial Activity ◽

Mass Spectral ◽

Fungal Organisms

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.

Download Full-text

N-(2-(1H-Indol-3-yl)ethyl)-2-(6-methoxynaphthalen-2-yl)propanamide

Molbank ◽

10.3390/m1187 ◽

2021 ◽

Vol 2021 (1) ◽

pp. M1187

Author(s):

Stanimir Manolov ◽

Iliyan Ivanov ◽

Dimitar Bojilov

Keyword(s):

Spectral Data ◽

13C Nmr ◽

Title Compound ◽

High Yield ◽

Mass Spectral Data ◽

Mass Spectral

The title compound was obtained in high yield in the reaction between tryptamine and naproxen. The newly synthesized naproxen derivative was fully analyzed and characterized via 1H, 13C-NMR, UV, IR, and mass spectral data.

Download Full-text

(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-Methyl-1H-tetrazol-5-yl)thio)Cyclopent-2-en-1-ol

Molbank ◽

10.3390/m1199 ◽

2021 ◽

Vol 2021 (2) ◽

pp. M1199

Author(s):

Milene A. G. Fortunato ◽

Filipa Siopa ◽

Carlos A. M. Afonso

Keyword(s):

Spectral Data ◽

13C Nmr ◽

Ring Opening ◽

Environmentally Friendly ◽

Mass Spectral Data ◽

Mass Spectral ◽

Excellent Yield ◽

Ring Opening Reaction ◽

Nucleophilic Ring Opening

Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via 1H, 13C-NMR, HSQC, and mass spectral data.

Download Full-text