scholarly journals Two Nitrogen-containing Compounds from Pseudostellaria heterophylla

2018 ◽  
Vol 13 (3) ◽  
pp. 1934578X1801300
Author(s):  
Xiang-Ming Liao ◽  
Xun He ◽  
Guo-Bo Xu ◽  
Zhen Wang ◽  
Jing Li ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Quantum Chemical ◽  
Model Compound ◽  
Spectroscopic Methods ◽  
Protective Effects ◽  
Myocardial Cells ◽  
Etoh Extract ◽  
Pseudostellaria Heterophylla ◽  
The Absolute ◽  
Nitrogen Containing Compounds

Two new nitrogen-containing compounds, pseudosteheterins A (1) and B (2), were isolated from the glycosides-enriched cardioprotective fraction of the 70% EtOH extract of the roots of Pseudostellaria heterophylla. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was established by quantum chemical TDDFT calculation of the ECD spectrum of its model compound. Pseudosteheterin B showed significant protective effects in H9c2 myocardial cells against CoCl2-induced injury.

scholarly journals A New Homoisoflavanone from the Rhizomes of Polygonatum cyrtonema

2013 ◽  
Vol 8 (5) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Li-She Gan ◽  
Jin-Jie Chen ◽  
Man-Fei Shi ◽  
Chang-Xin Zhou
Keyword(s):  
Dft Calculations ◽  
Absolute Configuration ◽  
Quantum Chemical ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Td Dft ◽  
Nmr Techniques ◽  
The Absolute

A new homoisoflavanone, (3 R)-5,7-dihydroxy-8-methyl-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (1), was isolated from the 95% ethanol extract of the rhizomes of Polygonatum cyrtonema. The structure of 1 was determined by spectroscopic methods, especially 2D NMR techniques. Quantum chemical TD DFT calculations of the theoretical ECD spectrum of 1 allowed assignment of the absolute configuration as 3R.

The synergy of different solid-state techniques to elucidate the supramolecular assembly of two 1H-benzotriazole polymorphs

2019 ◽  
Vol 21 (36) ◽  
pp. 19879-19889
Author(s):  
María Mar Quesada-Moreno ◽  
Juan Ramón Avilés-Moreno ◽  
Juan Jesús López-González ◽  
Fco. Javier Zúñiga ◽  
Dolores Santa María ◽  
...  
Keyword(s):  
Solid State ◽  
Quantum Chemical Calculations ◽  
Absolute Configuration ◽  
Quantum Chemical ◽  
Supramolecular Structure ◽  
Supramolecular Assembly ◽  
X Ray ◽  
X Ray Crystallography ◽  
The Absolute

4aα (chiral) and 4aβ (achiral) polymorphs of 1H-benzotriazole are studied by X-ray crystallography, SSNMR, IR, Raman, VCD, and quantum chemical calculations. The absolute configuration of the supramolecular structure of 4aα polymorph is determined.

scholarly journals Pseudosterins A–C, Three 1-Ethyl-3-formyl-β-carbolines from Pseudostellaria heterophylla and Their Cardioprotective Effects

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 5045
Author(s):  
Guo-Bo Xu ◽  
Qin-Feng Zhu ◽  
Zhen Wang ◽  
Chun-Li Zhang ◽  
Xin Yang ◽  
...  
Keyword(s):  
Quantum Chemical ◽  
Functional Food ◽  
Previous Investigation ◽  
Spectroscopic Analysis ◽  
Protective Effects ◽  
H9c2 Cells ◽  
Hypoxic Injury ◽  
Pseudostellaria Heterophylla ◽  
Reoxygenation Injury ◽  
Cardioprotective Effects

Pseudostellaria heterophylla is used in China not only as a functional food but also as an herb to tonify the spleen, enhance immunity, and treat palpitation. Our previous investigation showed that a fraction enriched in glycosides obtained from the roots of P. heterophylla possessed pronounced protective effects on H9c2 cells against CoCl2-induced hypoxic injury. However, the active compounds responsible for the observed effects were still unknown. In the current investigation, pseudosterins A–C (1–3), three new alkaloids with a 1-ethyl-3-formyl-β-carboline skeleton, together with polydatin, have been isolated from the active fraction. Their structures were elucidated on the basis of spectroscopic analysis and quantum chemical calculations. The four compounds showed cardioprotective effects against sodium hydrosulfite-induced hypoxia-reoxygenation injury in H9c2 cells, with the three alkaloids being more potent. This is also the first report of alkaloids with a β-carboline skeleton isolated from P. heterophylla as cardioprotective agents.

scholarly journals Five New Acylphloroglucinol Glycosides from the Leaves of Eucalyptus robusta

2014 ◽  
Vol 9 (2) ◽  
pp. 1934578X1400900
Author(s):  
Qian-Yi Guo ◽  
Xiao-Jun Huang ◽  
Bing-Xin Zhao ◽  
Yu-Qing Jian ◽  
Shi-Lin Luo ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Quantum Chemical ◽  
Spectrometric Analysis ◽  
The Absolute ◽  
Chemical Evidence

Five new acylphloroglucinol glycosides, robustasides A-E (1–5), together with a known one (6), were isolated from the leaves of Eucalyptus robusta. The structures were elucidated on the basis of extensive spectroscopic and spectrometric analysis and chemical evidence. The absolute configuration of 1 was further determined by quantum chemical CD calculation.

Enantioselective HPLC combined with spectroscopic methods: A valid strategy to determine the absolute configuration of potential β-secretase inhibitors

Talanta ◽  
2010 ◽  
Vol 82 (4) ◽  
pp. 1306-1312 ◽  
Author(s):  
Roberto Cirilli ◽  
Rosella Ferretti ◽  
Giuseppe La Regina ◽  
Gianluigi Morelli ◽  
Marco Pierini ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Spectroscopic Methods ◽  
The Absolute

Deoxy-cytochalasins from a marine-derived fungus Spicaria elegans

2009 ◽  
Vol 87 (3) ◽  
pp. 486-489 ◽  
Author(s):  
Zhen-Jian Lin ◽  
Tian-Jiao Zhu ◽  
Guo-Jian Zhang ◽  
Hong-Juan Wei ◽  
Qian-Qun Gu
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Absolute Configuration ◽  
Cancer Cell Lines ◽  
Spectroscopic Methods ◽  
Ester Method ◽  
The Absolute ◽  
Cytochrome P 450

Treatment of Spicaria elegans with cytochrome P-450 inhibitor resulted in two new deoxy-cytochalasins, 7-deoxy-cytochalasin Z7 (1) and 7-deoxy-cytochalasin Z9 (2), which were recognized as plausible precursors of cytochalasins Z7 and Z9, respectively. Their structures were elucidated by spectroscopic methods and the absolute configuration of 1 was determined by the conventional Mosher ester method. Their cytotoxicities against two cancer cell lines were evaluated.

Pigments of Fungi. LII Anisochiral Flavomannin 6,6′,8-Tri-O-methyl Ether from an Australian Dermocybe Toadstool

1999 ◽  
Vol 52 (8) ◽  
pp. 749 ◽  
Author(s):  
Malcolm S. Buchanan ◽  
Melvyn Gill ◽  
Alberto Gimenez ◽  
Somphone Phonh-Axa ◽  
Evelin Raudies ◽  
...  
Keyword(s):  
Natural Product ◽  
Methyl Ether ◽  
Absolute Configuration ◽  
Enantiomeric Purity ◽  
Chemical Degradation ◽  
Spectroscopic Methods ◽  
Fruiting Bodies ◽  
The Absolute

Flavomannin 6,6′,8-tri-O-methyl ether occurs in the fruiting bodies of the Australian toadstool Dermocybe sp. WAT 24274 as an anisochiral mixture of the (3S,3′S,P)- and (3R,3′R,M)-enantiomers (5) and (7), respectively, in which the former predominates to the extent of 50% e.e. The structure of the natural product is determined by spectroscopic methods and the absolute configuration and enantiomeric purity are deduced from the c.d. spectrum and by chemical degradation of the natural product to a mixture of stereoisomeric dihydroanthracenones that has been analysed by chiral h.p.l.c.

Enantioselective Diels-Alder reaction of (E)-1-trimethylsilyloxy-1,3-butadiene with chiral glyoxylates

1990 ◽  
Vol 55 (1) ◽  
pp. 230-244 ◽  
Author(s):  
Otakar Červinka ◽  
Aleš Svatoš ◽  
Petr Trška ◽  
Pavel Pech
Keyword(s):  
Nmr Spectroscopy ◽  
Quantum Chemical Calculations ◽  
Absolute Configuration ◽  
Quantum Chemical ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Chemical Correlation ◽  
The Absolute ◽  
C Nmr

Enantioselective Diels-Alder reaction of (E)-1-trimethylsilyloxy-1,3-butadiene (I) with chiral (-)-menthyl (II) and (-)-8-phenylmenthyl (III) glyoxylates in various solvents without or with catalysts was studied. The reactions gave a mixture of trans-and cis-isomers of (-)-menthyl (IV) and (-)-8-phenylmenthyl (V) 2-trimethylsilyloxy-5,6-dihydro-2H-pyran-6-carboxylates. The regioselectivity of the reaction was explained by quantum-chemical calculations, the enantioselectivity was determined using 13C NMR spectroscopy and the absolute configuration of the addition products was assigned on the basis of chemical correlation with (S)-(-)-dimethyl malate.

Sign in / Sign up

Export Citation Format

Share Document