scholarly journals Biotransformation of Bicyclic Sesqui- and Diterpene 1,2-dials and Their Derivatives by the Fungus, Aspergillus niger

2018 ◽  
Vol 13 (8) ◽  
pp. 1934578X1801300
Author(s):  
Yoshinori Asakawa ◽  
Masako Sekita ◽  
Toshihiro Hashimoto
Keyword(s):  
Aspergillus Niger ◽  
Metabolic Pathways ◽  
The Other ◽  
Naturally Occurring ◽  
Derivatives Of

Microbial biotransformation of naturally occurring pungent sesquiterpene 1,2-dials, polygodial and cinnamodial, and a diterpene 1,2-dial, sacculatal as well as their tetrahydro derivatives was carried out by using Aspergillus niger. The pungent polygodial and sacculatal are toxic against A. niger not to produce any metabolites while A. niger biotransformed cinnamodial to the lactonized products in small amount. On the other hands, the dihydroxy derivatives of the former two dialdehydes were bioconverted by the same fungus to give hydroxy-, oxo-, carboxylic- and epoxy-products. The stereostructures of each metabolite and their metabolic pathways were described.

scholarly journals Microbial Transformation of Some Natural and Synthetic Aromatic Compounds by Fungi: Aspergillus and Neurospora Strains

2017 ◽  
Vol 12 (8) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Nurunajah Ab Ghani ◽  
Nor Hadiani Ismail ◽  
Yoshiaki Noma ◽  
Yoshinori Asakawa
Keyword(s):  
Double Bond ◽  
Aspergillus Niger ◽  
Neurospora Crassa ◽  
Benzene Ring ◽  
Aromatic Compounds ◽  
Microbial Transformation ◽  
The Other ◽  
Aspergillus Species ◽  
Naturally Occurring ◽  
Direct Hydroxylation

Microbial transformation of chalcone (1), 4-hydroxychalcone (2) and 4′-hydroxychalcone (3), 1,1-diphenylmethane (4), 1,3-diphenylacetone (5), 1,3-diphenylpropane (6), bibenzyl (7), ( E)-stilbene (8a)- and ( Z)-stilbenes (8b), and phenylcyclohexane (9), (1 R,2 S)-1-phenyl-2-hydroxycyclohexane (9a) and (1 S,2 R)-1-phenyl-2-hydroxycyclohexane (9b), and a naturally occurring bis-bibenzyl, marchantin A (10) were performed by using Aspergillus niger TBUYN-2 and the other Aspergillus strains, and Neurospora crassa which were capable to hydrogenation and epoxidation of a conjugated double bond, and direct hydroxylation and hydroperoxidation on benzene ring, and hydroxylation and carbonization on cyclohexane ring. Aspergillus species converted chalcone (1) to dihydrochalcone (1a) almost quantitatively.

Energy Approximation

2017 ◽  
Author(s):  
Philip Isett
Keyword(s):  
Main Lemma ◽  
The Other ◽  
Coarse Scale ◽  
Continuous Solutions ◽  
Material Derivative ◽  
Energy Variation ◽  
Energy Approximation ◽  
The Difference ◽  
Derivatives Of

This chapter presents the equations and calculations for energy approximation. It establishes the estimates (261) and (262) of the Main Lemma (10.1) for continuous solutions; these estimates state that we are able to accurately prescribe the energy that the correction adds to the solution, as well as bound the difference between the time derivatives of these two quantities. The chapter also introduces the proposition for prescribing energy, followed by the relevant computations. Each integral contributing to the other term can be estimated. Another proposition for estimating control over the rate of energy variation is given. Finally, the coarse scale material derivative is considered.

scholarly journals II. Compounds isomeric with the sulphocyanic ethers.—I. On the mustard oil of the ethyl series

1868 ◽  
Vol 16 ◽  
pp. 254-258
Keyword(s):  
Royal Society ◽  
The Other ◽  
Mustard Oil ◽  
Other Hand ◽  
Derivatives Of

The results of my researches on the chloroform-derivatives of the primary monamines, which, as I have shown, are isomeric with the nitriles, could not fail to direct my attention to allied groups of bodies, with the view of discovering similar isomerisms. In a note communicated to the Royal Society some months ago, I expressed the expectations which even then appeared to be justified in the following manner:—“In conclusion, I may be permitted to announce as everv probable the existence of a series of bodies isomeric with the sulphocyanides. Already M. Cloëz has shown that the action of chloride of cyanogen on ethylate of potassium gives rise to the formation of an ethylic cyanate possessing properties absolutely different from those belonging to the cyanate discovered by M. Wurtz. On comparing, on the other hand the properties of the methylic and ethylic sulphocyamdes with those of the sulphocyanides of allyl and phenyl, it can scarcely be doubted that we have here the representatives of two groups entirely different, and that the terms of the methyl- and ethyl-series which correspond to oil of mustard, and to the sulphocyanide of phenyl, still remain to be discovered. Experiments with which I am now engaged will show whether these bodies cannot be obtained by the action of the iodides of methyl and ethyl on sulphocyanide of silver."

Interactions between DNA-bound trimers of the yeast heat shock factor

1994 ◽  
Vol 14 (1) ◽  
pp. 501-508
Author(s):  
J J Bonner ◽  
C Ballou ◽  
D L Fackenthal
Keyword(s):  
Heat Shock ◽  
Protein Complexes ◽  
Consensus Sequence ◽  
The Other ◽  
Inverted Repeats ◽  
Electrophoretic Mobilities ◽  
Naturally Occurring ◽  
Initial Identification ◽  
Dyad Symmetry ◽  
Chemical Cross Linking

The heat shock transcription factor (HSF) is a trimer that binds to DNA containing inverted repeats of the sequence nGAAn. HSF can bind DNA with the sequence nGAAnnTTCn or with the sequence nTTCnnGAAn, with little preference for either sequence over the other. However, (nGAAnnTTCn)2 is considerably less active as a heat shock response element (HSE) than is (nTTCnnGAAn)2. The electrophoretic mobilities of DNA-protein complexes and chemical cross-linking between protein monomers indicate that the sequence (nGAAnnTTCn)2 is capable of binding a single HSF trimer. In contrast, the sequence with higher biological activity, (nTTCnnGAAn)2, is capable of binding two trimers. Thus, the ability of four-nGAAn-element HSEs to bind one or two trimers depends on the permutation with which the elements are presented. A survey of naturally occurring HSEs shows the sequence (nTTCnnGAAn)2 to be the more prevalent. We suggest that the greater ability of one permutation over the other to bind two HSF trimers accounts for the initial identification of the naturally occurring heat shock consensus sequence as a region of dyad symmetry.

The synthesis of the isomeric N-methyl derivatives of murexine

1981 ◽  
Vol 34 (8) ◽  
pp. 1739 ◽  
Author(s):  
CC Duke ◽  
JV Eichholzer ◽  
JK Macleod
Keyword(s):  
Imidazole Ring ◽  
The Other ◽  
Pharmacological Activities ◽  
Tautomeric Forms ◽  
Methyl Derivatives ◽  
Paramagnetic Ions ◽  
Nucella Emarginata ◽  
Derivatives Of

The two isomeric N-methyl derivatives of murexine have been synthesised by independent routes and shown to be different from an 'N- methylmurexine' reportedly isolated from the mollusc Nucella emarginata. 1H n.m.r. studies have shown a marked difference in the extent of binding to paramagnetic ions of the two N-methyl derivatives of murexine in water while pharmacological results show substantially different pharmacological activities of the two isomers. Both results can be rationalized in terms of the observed activities being associated with the presence of one or the other of the tautomeric forms of the imidazole ring.

Cleavage Reactions of 5-Arylazo Derivatives of 1-Methyl-2-benzyl-2-imidazolin-4-ones

1975 ◽  
Vol 30 (7-8) ◽  
pp. 603-605 ◽  
Author(s):  
Nazmi Abdel Latif Kassab ◽  
Abdel Hamid Harhash ◽  
Sanna Osman Abd Allah
Keyword(s):  
Sodium Hydroxide Solution ◽  
Aqueous Sodium Hydroxide ◽  
The Other ◽  
Ring Cleavage ◽  
Prolonged Heating ◽  
Aqueous Sodium Hydroxide Solution ◽  
Aqueous Sodium ◽  
Triazine Derivatives ◽  
Cleavage Reactions ◽  
Derivatives Of

The 5-arylazo-1-methyl-2-benzyl-2-imidazolin-4-ones (1 a-c) undergo ring cleavage with 1% aqueous sodium hydroxide solution affording α-arylhydrazono-phenacetyl-sarcosine amide (2). Prolonged heating of 1 and 2 with the same reagent yields the cyanamide (3). On the other hand, when 1 a-c were refluxed with acetic acid the triazinones (4) were obtained. The latter adds one mole of Grignards reagent to yield the 5-hydroxy-1,2,4-triazine derivatives (5).

Application of Maple on Solving the Differential Problem of Rational Functions

2013 ◽  
Vol 479-480 ◽  
pp. 855-860
Author(s):  
Chii Huei Yu
Keyword(s):  
Problem Solving ◽  
Research Methods ◽  
Research Method ◽  
Rational Functions ◽  
The Other ◽  
Mathematical Software ◽  
Differential Problem ◽  
Binomial Theorem ◽  
Other Hand ◽  
Derivatives Of

This paper uses the mathematical software Maple as the auxiliary tool to study the differential problem of four types of rational functions. We can obtain the closed forms of any order derivatives of these rational functions by using binomial theorem. On the other hand, we propose four examples to do calculation practically. The research methods adopted in this study involved finding solutions through manual calculations and verifying these solutions by using Maple. This type of research method not only allows the discovery of calculation errors, but also helps modify the original directions of thinking from manual and Maple calculations. For this reason, Maple provides insights and guidance regarding problem-solving methods.

scholarly journals The Glucosamine Controversy; A Pharmacokinetic Issue

2011 ◽  
Vol 14 (2) ◽  
pp. 264 ◽  
Author(s):  
Ali Aghazadeh-Habashi ◽  
Fakhreddin Jamali
Keyword(s):  
Clinical Trial ◽  
Animal Studies ◽  
The Other ◽  
Naturally Occurring ◽  
Assessment Metrics ◽  
Disease Modifying ◽  
Clinical Trial Results ◽  
Higher Doses ◽  
Positive Results ◽  
Rule Out

Glucosamine (GlcN) is a naturally occurring aminosugar that is widely used to treat osteoarthritis despite controversial clinical trial results. Animal studies, on the other hand, unequivocally suggest anti-inflammatory and disease modifying effects for GlcN. Many explanations have been offered as to the root of the controversy. They include superiority of a crystalline sulphate salt over HCl, industry bias, insensitive assessment metrics and poor methodology. Herein, we rule out a difference in bioequivalence between GlcN salts and that of chemically equivalent doses and suggest additional factors; i.e., inconsistency in the chemical potency of some products used, under-dosing of patients as well as variable and erratic bioavailability indices for the lack of GlcN efficacy observed in some studies. Clinical trials using higher doses of pharmaceutical grade GlcN or formulations with greater bioavailability should yield positive results. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Municipal Representatives’ Accounts of Decision-Making Practices during Geriatric Case Conferences

2017 ◽  
Vol 23 (45) ◽  
pp. 129
Author(s):  
Søren Beck Nielsen
Keyword(s):  
Senior Citizens ◽  
General Characteristic ◽  
The Other ◽  
Residential Home ◽  
Residential Homes ◽  
Social Actors ◽  
Naturally Occurring ◽  
Case Conferences ◽  
The Relationship ◽  
Elderly Citizen

This article addresses questions of elucidation in talk-in-interaction. How do social actors give accounts of what they are doing? To what degree do actors sustain a taken-for-granted level of reasoning? The analysis is based upon naturally occurring data consisting of a corpus of audio recorded case conferences at various geriatric wards in Danish hospitals. The article elaborates one of the important insights of Harold Garfinkel regarding the relationship between discourse and social interaction: as a general characteristic, people tend to treat their fellow interlocutors’ conversational contributions as adequate for-all-practical-purposes. Specifically, the article investigates how Danish municipal representatives account for their decisions about whether or not senior citizens are to be referred to residential homes. This practice, I demonstrate, is characterized by non-explicitness with regards to rules and regulations. Instead, municipal representatives make use of developmental discourse: a worsened condition is used to justify a referral to a residential home. On the other hand, an improved condition is used to justify that an elderly citizen is not referred to a residential home.

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