scholarly journals Vitamin D Supplementation in Military Personnel: A Systematic Review of Randomized Controlled Trials

2019 ◽  
Vol 11 (5) ◽  
pp. 425-431
Author(s):  
Gaya Sivakumar ◽  
Alex Koziarz ◽  
Forough Farrokhyar
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Controlled Trials ◽  
Military Personnel ◽  
Vitamin D Supplementation ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Positive Trend ◽  
Musculoskeletal Health ◽  
Randomized Controlled

Context: Vitamin D supplementation is important in military research because of its role in musculoskeletal health. Objective: This systematic review examined the effects of vitamin D supplementation on serum 25-hydroxyvitamin D (25(OH)D) concentrations and musculoskeletal health outcomes in military personnel. Data Sources: A comprehensive search was conducted using MEDLINE, EMBASE, CINAHL, SportDiscus, and the Cochrane Library databases and the reference lists of existing review articles and relevant studies. Study Selection: Reviewers independently screened titles, abstracts, and full texts of the articles using predefined criteria. Study Design: Systematic review of randomized controlled trials (RCTs) using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Level of Evidence: Level 3. Data Extraction: Three reviewers independently extracted data and assessed the methodological quality. Mean differences with 95% CI in serum 25(OH)D concentrations between the vitamin D and placebo arms were calculated. Results: Four RCTs were included in the qualitative analyses. The 25(OH)D concentrations were improved with 2000 IU/d supplementation (mean difference, 3.90 ng/mL; 95% CI, 0.22-7.58). A trial on female Navy recruits showed a significant decrease in stress fractures (risk ratio, 0.77; 95% CI, 0.62-0.95), particularly tibial fractures, from daily supplementation of 800 IU vitamin D and 2000 mg calcium. Conclusion: There was a positive trend in 25(OH)D concentrations from higher doses of supplementary vitamin D in military submariners and a possible benefit to bone health when vitamin D was combined with calcium.

scholarly journals Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Shan Guo ◽  
Reshef Tal ◽  
Haoyu Jiang ◽  
Tao Yuan ◽  
Ying Liu
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Controlled Trials ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Serum Triglyceride ◽  
Vitamin D Supplementation ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Randomized Controlled

Objective. Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. Methods. Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444. Results. Thirteen randomized controlled trials with 824 patients in total were included. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. Vitamin D supplementation group also showed a significantly elevated level of QUICKI. No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP. Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml). Conclusion. The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.

Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Vol 11 (12) ◽  
pp. 10817-10827
Author(s):  
Chunxiao Liu ◽  
Xiaotong Kuang ◽  
Kelei Li ◽  
Xiaofei Guo ◽  
Qingxue Deng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Controlled Trials ◽  
Postmenopausal Women ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Randomized Controlled

The aim of the present study was to explore whether combined calcium and vitamin D supplementation is beneficial for osteoporosis in postmenopausal women.

scholarly journals Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials

2015 ◽  
Vol 73 (9) ◽  
pp. 577-593 ◽  
Author(s):  
Paulette D. Chandler ◽  
Lu Wang ◽  
Xi Zhang ◽  
Howard D. Sesso ◽  
Manickavasagar V. Moorthy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Randomized Controlled
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