scholarly journals Practical advantage of SPECT/CT image co-registration for accurate bleeding Meckel’s diverticulum localization in pediatrics: A case report

2021 ◽  
pp. 201010582110310
Author(s):  
Nashrulhaq Tagiling ◽  
Vincent Wei Shen Tee ◽  
Yeong Yeh Lee ◽  
Nur Asyilla Che Jalil ◽  
Norazlina Mat Nawi
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Meckel’S Diverticulum ◽  
Photon Emission ◽  
Meckel's Diverticulum ◽  
Ectopic Gastric Mucosa ◽  
Emission Computed Tomography ◽  
Ct Scanner ◽  
Practical Advantage ◽  
The Right

Planar scintigraphy with 99mTc-pertechnetate or Meckel scan is the gold standard in the diagnosis of a bleeding Meckel’s diverticulum (MD) for pediatrics. However, several setbacks may occur during the interpretation of a scintigram, especially in cases of an atypical MD presentation. In this report, we highlight the importance of functional and anatomical image co-registration using a hybrid SPECT/CT scanner to precisely localize a MD lesion. An 18-month-old boy presented with severe hematochezia over 4 days with declining hemoglobin levels. He underwent a conventional 60-min dynamic planar imaging of the Meckel scan. Upon review of the Meckel scan, a suspicious increase in the 99mTc-pertechnetate uptake was observed at the right upper quadrant of the abdomen. Due to its atypical location at the right kidney, we could not differentiate between a physiological uptake of the right kidney or an ectopic gastric mucosa. The patient was imaged again using single-photon emission computed tomography (SPECT) and low-dose CT protocol with a hybrid SPECT/CT scanner, and the co-registration of both SPECT and CT images was able to confirm the MD, which was located anterior to the right kidney at the right hepatic flexure region. An exploratory laparotomy was then ensued to remove the bleeding MD. The patient was discharged after 3 days with no complications. In summary, this case illustrates that hybrid imaging modality and co-registration allow for a more definitive diagnosis, as well as a more precise localization of MD.

scholarly journals Shifting of global aphasia to Wernicke’s aphasia in a patient with intact motor function: a case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ya-Chi Chuang ◽  
Chuan-Ching Liu ◽  
I-Ching Yu ◽  
Yu-Lin Tsai ◽  
Shin-Tsu Chang
Keyword(s):  
Computed Tomography ◽  
Right Hemisphere ◽  
Single Photon ◽  
Ct Perfusion ◽  
Single Case ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Speech Fluency ◽  
Language Functions ◽  
The Right

Abstract Background Global aphasia without hemiparesis (GAWH) is a rare stroke syndrome characterized by the dissociation of motor and language functions. Here, we present a case of GAWH with the patient later regaining speech fluency. Case presentation A 73-year-old man was admitted to our emergency department immediately after an episode of syncope. On arrival, we noted his global aphasia but without any focal neurologic signs. Computed tomography (CT) perfusion scans showed a large hypodense region over his left perisylvian area. Under the impression of acute ischaemic stroke, he received recombinant tissue plasminogen activator (rtPA) injection and was treated as an inpatient. The patient was later discharged with GAWH status and received regular speech rehabilitation. After 14 months of rehabilitation, the patient gradually recovered his language expression ability. The degree of aphasia was evaluated with the Concise Chinese Aphasia Test (CCAT), and we obtained brain single photon emission computed tomography (SPECT) scans to assess cerebral blood flow. Conclusion A patient with severe impairments of Broca’s and Wernicke’s areas was able to talk fluently despite being unintelligible. SPECT revealed relative high level of radioactivity uptake in the right frontal lobe, suggesting the deficits in speech fluency could have been compensated by the right hemisphere. Although this is a single case demonstration, the results may strengthen the role of the right hemisphere in GAWH patients and suggests additional study that examines the possible benefits of stimulating activity at right homologous regions for recovering language function after global aphasia.

scholarly journals Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

2021 ◽  
Vol 22 (9) ◽  
pp. 4804
Author(s):  
Vincent Q. Sier ◽  
Joost R. van der Vorst ◽  
Paul H. A. Quax ◽  
Margreet R. de Vries ◽  
Elham Zonoobi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Diseases ◽  
Near Infrared ◽  
Transforming Growth Factor ◽  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Nirf Imaging ◽  
Efficient Detection

Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the progress in endoglin-based imaging of cancer, atherosclerosis, myocardial infarction, and aortic aneurysm, focusing on positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), near-infrared fluorescence (NIRF) imaging, and ultrasound imaging. PubMed was searched combining the following subjects and their respective synonyms or relevant subterms: “Endoglin”, “Imaging/Image-guided surgery”. In total, 59 papers were found eligible to be included: 58 reporting about preclinical animal or in vitro models and one ex vivo study in human organs. In addition to exact data extraction of imaging modality type, tumor or cardiovascular disease model, and tracer (class), outcomes were described via a narrative synthesis. Collectively, the data identify endoglin as a suitable target for intraoperative and diagnostic imaging of the neovasculature in tumors, whereas for cardiovascular diseases, the evidence remains scarce but promising.

scholarly journals Cerebral Hemispheric and Contralateral Cerebellar Hypoperfusion during a Transient Ischemic Attack

1987 ◽  
Vol 7 (4) ◽  
pp. 507-509 ◽  
Author(s):  
Daniela Perani ◽  
Paolo Gerundini ◽  
Gian Luigi Lenzi
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Complete Recovery ◽  
Emission Computed Tomography ◽  
Left Middle Cerebral Artery ◽  
Single Photon Emission Computed ◽  
Ischemic Attack ◽  
The Right ◽  
Photon Emission Computed Tomography ◽  
Left Middle

We studied a 79-year-old woman within 3 h of the onset of a motor aphasia and a right hemiparesis. Single photon emission computed tomography (SPECT) showed a 24% decrease in the perfusion of the left middle cerebral artery territory and a 16% reduction in the perfusion of the right cerebellum. A mild naming difficulty was the neurological deficit at the end of the SPECT examination, and complete recovery was achieved within 24 h. Repeated SPECT study 10 days later was normal. This is the first report of focal hemispheric and contralateral cerebellar hypoperfusion in transient cerebral ischemia.

Basic principles and technological state of the art: SPECT

ESC CardioMed ◽  
2018 ◽  
pp. 573-577
Author(s):  
Alessia Gimelli ◽  
Riccardo Liga
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Nuclear Imaging ◽  
The Body ◽  
Emission Computed Tomography ◽  
Non Invasive ◽  
Photon Emission Computed Tomography ◽  
Invasive Evaluation

Single-photon emission computed tomography (SPECT) photons as a medical imaging technique detects the radiation emitted by radioisotopes injected into the body to provide in vivo measurements of regional tissue function. From its introduction in the cardiologic clinical field, nuclear imaging has classically represented the reference technique for the non-invasive evaluation of myocardial perfusion, becoming the most frequently performed imaging modality for the functional assessment of patients with ischaemic heart disease.

scholarly journals Modification of both functional neurological symptoms and neuroimaging patterns with a good anatomoclinical concordance: a case report

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Silvio Galli ◽  
Selma Aybek ◽  
Sylvie Chokron ◽  
Thierry Moulin ◽  
Eloi Magnin
Keyword(s):  
Neurological Disorder ◽  
Parietal Lobe ◽  
Single Photon ◽  
Photon Emission ◽  
Conversion Disorder ◽  
Emission Computed Tomography ◽  
Sensorimotor Deficit ◽  
Neural Underpinnings ◽  
The Right ◽  
Functional Neurological Disorder

Abstract Background In the nineteenth century, Jean Martin Charcot explained functional neurological disorder (formerly called conversion disorder) as a “psychodynamic” lesion. Numerous advances in neuroimaging have permitted identification of the neural underpinnings of this disorder. Case presentation Herein we describe a case of functional neurological disorder (FND) with initial left sensorimotor deficit, in-coordinated limb movements, neglect, clouded consciousness, slurred speech and a semiology of visual impairment. A single photon emission computed tomography (SPECT) showed a right thalamic hypoperfusion, which is rather concordant with the initial semiology. Later, the semiology changed, presenting with a predominantly neurovisual complex presentation. The second SPECT showed no more thalamic abnormalities but an hypoperfusion in the right temporo-occipital junction, right inferior parietal lobe and left superior frontal lobe, which is also rather concordant with the changing semiology. Conclusions This case illustrates the evolving neuroimaging patterns of FND but also the concordance between semiology and neuroimaging findings in FND supporting Charcot's theory of “dynamic lesion”.

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Open Medicine ◽  
2007 ◽  
Vol 2 (4) ◽  
pp. 499-510 ◽  
Author(s):  
Wolfgang Wuest ◽  
Torsten Kuwert ◽  
Markus Grunewald ◽  
Werner Bautz ◽  
Raimund Forst ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Hybrid Imaging ◽  
Single Photon ◽  
Photon Emission ◽  
Interdisciplinary Approach ◽  
Spiral Ct ◽  
Emission Computed Tomography ◽  
Main Diagnosis ◽  
Ct Scanner ◽  
Lesion Localization

AbstractBone scintigraphy, although quite sensitive to detect skeletal lesions, has a comparatively low specificity. Hybrid-cameras combining single-photon emission computed tomography (SPECT) and spiral-CT offer the opportunity to correlate scintigraphic information with high-quality visualization of morphology in one session. This may lead to an improvement in diagnostic accuracy and anatomic lesion localization. We present 11 patients, who underwent SPECT/CT of the feet (n=10) and hands (n = 1). The examinations were performed due to pain in foot or hand with the following suspected clinical diagnoses: arthrosis (n=1); fracture (n=3); osteomyelitis (n=4); reflex dystrophia (n=1); and, pain of unclear origin (n=2). All patients underwent SPECT/CT hybrid imaging using a dual-headed SPECT camera integrated with a 2-slice spiral CT scanner in one gantry. SPECT, CT, and SPECT/CT were evaluated independently from each other with respect to main diagnosis, anatomic lesion localization, and detection of a possible additional diagnosis. SPECT/CT improved lesion localization in 8 of 11 patients (73%) in comparison to SPECT alone, and in 4 of 11 patients (36%) in comparison to CT alone. Diagnostic accuracy was improved in 4 of 11 patients (36%) in comparison to either SPECT or CT alone. In conclusion, skeletal SPECT/CT improves diagnostic accuracy and lesion localization of orthopedic disorders in the feet and hands. The obtained results encouraged extensive studies to further investigate the potential gain in diagnostic accuracy brought about by SPECT/spiral-CT hybrid imaging in orthopedic disorders of the peripheral extremities.

scholarly journals Myocardial ischemia in patients with pulmonary arterial hypertension

2015 ◽  
Vol 12 (4) ◽  
pp. 52-56
Author(s):  
O A Arkhipova ◽  
T V Martyniuk ◽  
E G Valeeva ◽  
G V Ryabykina ◽  
L E Samoylenko ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Myocardial Ischemia ◽  
Pulmonary Artery ◽  
Arterial Hypertension ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Coronary Insufficiency ◽  
Pulmonary Arterial ◽  
The Right

The precordial region. Pain in the chest in these patients is associated with relative coronary insufficiency due to low cardiac output, a relatively weak development of coronary collaterals on the background of hypertrophy of the wall of the right ventricle or reflex constriction of the coronary arteries due to distension of the pulmonary artery (viscero-visceral reflex), lowest saturation of blood oxygen at an advanced stage, as well as compression of the left main coronary artery dilutionin the pulmonary artery trunk. Many of them in electrocardiography revealed changes similar to ischemic. The purpose of this study was to identify signs of myocardial ischemia in patients with pulmonary arterial hypertension and evaluate the relationship of pain with the presence of ischemic changes according to 12 channel Holter ECG monitoring, and synchronized single photon emission computed tomography myocardial alone and in combination with load tests.

Basic principles and technological state of the art: SPECT

2018 ◽  
Author(s):  
Alessia Gimelli ◽  
Riccardo Liga
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Nuclear Imaging ◽  
The Body ◽  
Emission Computed Tomography ◽  
Basic Principles ◽  
Non Invasive ◽  
Photon Emission Computed Tomography

Single-photon emission computed tomography (SPECT) photons as a medical imaging technique detects the radiation emitted by radioisotopes injected into the body to provide in vivo measurements of regional tissue function. From its introduction in the cardiologic clinical field, nuclear imaging has classically represented the reference technique for the non-invasive evaluation of myocardial perfusion, becoming the most frequently performed imaging modality for the functional assessment of patients with ischaemic heart disease.

scholarly journals Cardiac PET-CT: A Brief Review of Indications and Feasibility in the Indian Scenario

2020 ◽  
Vol 5 (02) ◽  
pp. 129-136
Author(s):  
Kavitha Nallapareddy ◽  
V. L. Gowthami Rayaprolu
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Myocardial Inflammation ◽  
Emission Computed Tomography ◽  
Cardiac Positron Emission Tomography ◽  
Positron Emission ◽  
Perfusion Agents ◽  
Perfusion Assessment ◽  
Positron Emitters

AbstractCardiac positron emission tomography (PET) is a functional imaging modality with the predominant indications being an assessment of myocardial perfusion and viability using short-lived positron emitters. PET procedures are used for perfusion assessment only when single-photon emission computed tomography is equivocal. Perfusion agents are ultra short-lived and have limited availability in our country, that is, only at centers with onsite cyclotron. Viability assessment with fluorodeoxyglucose (FDG) is widely performed in many centers across the country due to the availability of FDG. The other important indication is in the detection of inflammatory myocarditis, the most common being cardiac sarcoidosis done with special dietary instructions and FDG as a tracer. This indication is widely used for early detection of myocardial inflammation which would be reversible if treated early. It is also used in the assessment of treatment response. Newer tracer 68 Ga Dotapeptide is also used in this application.

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