Remission of type 2 diabetes and pleiotropic effects of long-term testosterone treatment for “late-onset” hypogonadism: A case report

For obese type 2 diabetes patients, weight reduction is one of the most important measures but fails in most cases. Testosterone deficiency can be the reason for such failure. This case presents a 57-year-old man who was referred to a urologist due to benign prostatic hyperplasia and erectile dysfunction. He had type 2 diabetes, was overweight, and had hypertension and dyslipidemia. The blood test revealed testosterone deficiency. Under testosterone therapy, the patient lost 10 kg; cardiometabolic parameters returned to normal and lower urinary tract symptoms disappeared; complete remission of diabetes was recorded. Overweight and obese patients with type 2 diabetes should be tested for hypogonadism and testosterone therapy, if indicated, be considered. These patients can considerably benefit from testosterone therapy in terms of sustainable weight loss and a clinically significant reduction of cardiometabolic risk factors including complete remission of diabetes.

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Remission of type 2 diabetes in a hypogonadal man under long-term testosterone therapy

Endocrinology Diabetes and Metabolism Case Reports ◽

10.1530/edm-17-0084 ◽

2017 ◽

Vol 2017 ◽

Cited By ~ 2

Author(s):

Ahmad Haider ◽

Karim S Haider ◽

Farid Saad

Keyword(s):

Type 2 Diabetes ◽

Complete Remission ◽

Treatment Plan ◽

Daily Practice ◽

List Type ◽

Testosterone Therapy ◽

Laboratory Values ◽

Normal Ranges ◽

Remission Of Diabetes

Summary In daily practice, clinicians are often confronted with obese type 2 diabetes mellitus (T2DM) patients for whom the treatment plan fails and who show an inadequate glycemic control and/or no sustainable weight loss. Untreated hypogonadism can be the reason for such treatment failure. This case describes the profound impact testosterone therapy can have on a male hypogonadal patient with metabolic syndrome, resulting in a substantial and sustained loss of body weight, pronounced improvement of all critical laboratory values and finally complete remission of diabetes. Learning points: Hypogonadism occurs frequently in men with T2DM. In case of pronounced abdominal fat deposition and T2DM, the male patient should be evaluated for testosterone deficiency. Untreated hypogonadism can complicate the successful treatment of patients with T2DM. Under testosterone therapy, critical laboratory values are facilitated to return back to normal ranges and even complete remission of diabetes can be achieved.

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Erectile dysfunction as a marker of renal function deterioration in type 2 diabetes male patients with late onset hypogonadism

Journal of Men s Health ◽

10.1016/j.jomh.2011.08.073 ◽

2011 ◽

Vol 8 (3) ◽

pp. 231-231

Author(s):

V. Luchytskiy ◽

V. Rybalchenko ◽

E. Luchytskiy ◽

G. Zubkova ◽

Y. Zasieda

Keyword(s):

Type 2 Diabetes ◽

Renal Function ◽

Erectile Dysfunction ◽

Late Onset ◽

Renal Function Deterioration ◽

Male Patients ◽

Late Onset Hypogonadism

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P707Endothelial function and testosterone deficiency in men with type 2 diabetes mellitus

European Heart Journal ◽

10.1093/eurheartj/ehz747.0312 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

I Khripun ◽

S Vorobyev ◽

A Khripun ◽

M Kogan ◽

I Belousov

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Carbohydrate Metabolism ◽

Clinical Symptoms ◽

Late Onset ◽

Vascular Complications ◽

Vasomotor Function ◽

Late Onset Hypogonadism

Abstract Background To date, the currently available data aboutthe effect of testosterone (T) on the cardiovascular system of men are highly controversial. The particular interest is its effect on the endothelium in men with type 2 diabetes mellitus (T2DM) having a high risk of vascular complications. The purpose of this work was to evaluate the effect of endogenous T on function of endothelium in men with T2DM. Methods The study included 204 men, aged 40–65 years, with T2DM. Patients underwent clinical examinations, analysis of carbohydrate metabolism, evaluation of biochemical parameters of endothelial function such as nitric oxide (NO), endothelial synthase type 3 (eNOS3), VCAM-1, ICAM-1, p- and e-selectins, endothelin. The ultrasound assessment of flow-mediated dilatation of the brachial artery (FMD-BA) and intima-media thickness (IMT) of brachial arteries were performed. Patients were divided into 2 groups: 1 – 93 men with late onset hypogonadism established according to EAU 2015 criteria and 2 – 111 men having normal level of endogenous T and absence of clinical symptoms of hypogonadism. Statistical analysis of the data was carried out using the Mann-Whitney U-test (STATISTICA 10 software package). Results The parameters of carbohydrate metabolism and the duration of T2DM were comparable in two groups. The concentrations of NO (85.0 [60.4; 210.4] vs 137.5 [87.8; 281.5] μmol/l, p=0.001) and eNOS3 (192.2 [109.6; 407.3] vs 293.3 [117.1; 686.2] pg/ml, p=0.03) were lower in the 1st group compared to the 2nd one. There was an increase in the levels of VCAM-1 by 32.6% and ICAM-1 by 43% (p<0.0001), p-selectin by 19.5% (p=0.003) in the 1st group compared to the 2nd group. The endothelium-dependent FMD-BA was less pronounced (9.4 [6.9; 13.0] vs 12.2 [10.0; 16.7] %, p=0.0007) and had a delay in time of dilation by 33.3% in patients with hypogonadism compared to eugonadal men. There was an increase in IMT (1.0 [0.9; 1.2] vs 0.9 [0.7; 1.1] mm, p=0.03) in the 1st group compared to the 2nd. Conclusion T deficiency in men with T2DM leads to endothelial dysfunction, decreasing secretory and vasomotor function of endothelium. This indicates the raise of cardiovascular risk and predicts progression of vascular complications in men with T2DM and late onset hypogonadism. Acknowledgement/Funding Supported by Russian Science Foundation, grant #14-25-00052.

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