Blindness paving the path to the diagnosis of metastatic prostate carcinoma: A unique case presentation

2021 ◽  
pp. 205141582110537
Author(s):  
Aadhar Jain ◽  
Anveshi Nayan ◽  
Sujata Patwardhan
Keyword(s):  
Vision Loss ◽  
Specific Antigen ◽  
Primary Source ◽  
Metastatic Lesion ◽  
Unique Case ◽  
Case Presentation ◽  
Intracranial Metastases ◽  
Appropriate Therapy ◽  
Brain Involvement ◽  
Metastatic Prostate Carcinoma

Background: Intracranial metastases from prostate adenocarcinoma are very unusual and typically occur late in the course of the disease, and initial presentation with symptomatic brain involvement, especially vision loss is very rare (with this being only the sixth such reported case to the best of our knowledge). The present case elucidates how a diagnosis was reached in such a scenario and the management provided. Case presentation: A 66-year-old gentleman presented with loss of vision and headache with no other ocular or neurological complaint. Computed tomography (CT) of his head revealed a destructive lesion involving the clivus and a space-occupying lesion (SOL) in occipito-parietal region. Detailed inquiry regarding the possible primary source of suspected the metastatic lesion revealed an increased frequency of urination, nocturia, and significant weight loss. His serum prostate-specific antigen (PSA) levels were raised. He was treated by surgical hormonal therapy and his visual symptoms improved. Conclusion: Awareness of such a presentation can lead to an accurate diagnosis. Initiation of appropriate therapy can successfully alleviate the neurologic deficits.

scholarly journals Retroperitoneal fibrous tumor recurring as lung metastases after 10 years: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kozue Matsuishi ◽  
Kojiro Eto ◽  
Atsushi Morito ◽  
Hirokazu Hamasaki ◽  
Keisuke Morita ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Distant Metastasis ◽  
Curative Resection ◽  
Lung Metastases ◽  
Lung Resection ◽  
Left Lung ◽  
Metastatic Lesion ◽  
Case Presentation ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor (SFT) is a relatively rare mesenchymal tumor that mainly affects adults. Its prognosis is good after curative resection, but distant recurrences after 10 years or longer have been reported. Recurrent SFT usually arises as a local lesion; distant metastasis is rarely reported. Here, we report lung metastases that recurred a decade after excising a retroperitoneal primary SFT. Case presentation A 44-year-old woman had an SFT resected from her right retroperitoneum at our hospital. Ten years later, at age 54, she underwent a lung resection after CT showed three suspected metastases in her left lung. All three were histologically diagnosed as lung metastases from the retroperitoneal SFT. However, whereas the primary SFT had 1–2 mitotic cells/10 high power fields (HPF), the metastatic lesion increased malignancy, at 50/10 HPF. Conclusion Patients who have had resected SFTs should be carefully followed up, as malignancy may change in distant metastasis, as in this case.

scholarly journals Malakoplakia in a colonic tubular adenoma: a unique case presentation

2018 ◽  
Vol 67 (6) ◽  
pp. 365-369
Author(s):  
Akash Gupta ◽  
Abdalla Saad Abdalla Al-Zawi ◽  
Asghar Naqvi ◽  
Samih Salama ◽  
Salem Alawami ◽  
...  
Keyword(s):  
Tubular Adenoma ◽  
Unique Case ◽  
Case Presentation

scholarly journals Pancreatic inflammatory myofibroblastic of the pancreatic neck: a case report and literature review

2020 ◽  
Author(s):  
Zhitao Chen ◽  
Yaoxiang Lin ◽  
Mengxia Li ◽  
Ting Zhang ◽  
Lele Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Inflammatory Myofibroblastic Tumor ◽  
Inflammatory Cell ◽  
Pancreatic Neuroendocrine Tumor ◽  
Neck Mass ◽  
Pathological Diagnosis ◽  
Unique Case ◽  
Case Presentation ◽  
Histological Features ◽  
Pancreatic Neck

Abstract BackgroundPancreatic inflammatory myofibroblastic tumor (IMT) is a relatively rare disease, which is often confused with pancreatic cancer or pancreatic neuroendocrine tumor. Its histological features are fibroblast and myofibroblast proliferation, accompanied by varying degrees of inflammatory cell infiltration. Case presentationHerein, we presented the management of IMT occurring at the neck of pancreas. A 66-year-old female patient was diagnosed as pancreatic neck mass after a series of tests. Then she underwent enucleation of pancreatic neck tumor followed by pathological diagnosis of IMT. Meanwhile, we reviewed the clinical features and pathological diagnosis and treatment of pancreatic IMT which were previously reported. To our knowledge, this is the unique case of enucleation of pancreatic IMT. ConclusionIn the management of pancreatic IMT, we concluded that enucleation may be a safe and efficient surgical method for the management of pancreatic IMT and may also provide a better prognosis. Further accumulation of cases is required to explore the surgical measure of pancreatic IMTs.

scholarly journals A unique case of vision loss in a patient with hypotrichosis and juvenile macular dystrophy and primary ciliary dyskinesia

2019 ◽  
Vol 15 ◽  
pp. 100486
Author(s):  
Kenneth C. Fan ◽  
Nimesh A. Patel ◽  
Nicolas A. Yannuzzi ◽  
Supalert Prakhunhungsit ◽  
Catherin I. Negron ◽  
...  
Keyword(s):  
Primary Ciliary Dyskinesia ◽  
Vision Loss ◽  
Macular Dystrophy ◽  
Unique Case ◽  
Ciliary Dyskinesia

scholarly journals Legionella micdadei: A Forgotten Etiology of Growing Cavitary Nodules: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Daniel Lachant ◽  
Paritosh Prasad
Keyword(s):  
Chest Ct ◽  
Shortness Of Breath ◽  
Negative Bacterium ◽  
Case Presentation ◽  
Atypical Pathogen ◽  
Transthoracic Biopsy ◽  
Immunosuppressed Patients ◽  
Appropriate Therapy ◽  
Immunocompromised Hosts ◽  
Legionella Micdadei

Background.Legionella micdadeiis a Gram negative bacterium that can stain weakly acid fast. It was first described in 1979 after immunosuppressed patients developed pneumonia at a Pittsburgh VA, initially given the name Pittsburgh Pneumonia Agent. It is the second most commonLegionellaspecies causing infection afterpneumophila, and typically infects immunocompromised hosts. It is not easy to be cultured which makes diagnosing difficult.Case Presentation. A 31-year-old female with ulcerative colitis, primary sclerosing cholangitis, and cirrhosis presented with fever, chills, shortness of breath, dry cough, and chest pain for five days after being started on immunosuppression for autoimmune hepatitis two months earlier. The first chest CT showed small bilateral cavitary nodules. The nodules continued to grow on subsequent imaging despite what was thought to be appropriate therapy. A transthoracic biopsy was performed which grewLegionella micdadeiand the patient improved after being treated with levofloxacin.Conclusion.Legionella micdadeiis an atypical pathogen known to cause pneumonia in immunosuppressed patients. This case highlights a typical presentation of an atypical infection not commonly thought about and should be considered when nodules are growing despite being on broad antimicrobial therapy.

scholarly journals Gallbladder Metastases: A Report of Two Cases

2019 ◽  
Vol 12 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Mohamad Mouchli ◽  
Douglas J. Grider ◽  
Paul Yeaton
Keyword(s):  
Computed Tomography ◽  
Invasive Ductal Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Primary Lung Cancer ◽  
Gallbladder Wall ◽  
Metastatic Lesion ◽  
Quadrant Pain ◽  
Case Presentation ◽  
Enhanced Computed Tomography

Introduction: Metastasis to the gallbladder is not common and usually manifests an advanced stage of malignancy. Herein, we report a case of triple negative high grade invasive ductal carcinoma of breast with a metastatic lesion to the gallbladder. Case Presentation: The patient is a 52-year-old female diagnosed with invasive ductal carcinoma treated with mastectomy and chemotherapy. After 12 months, she presented to the emergency department with right upper quadrant pain and elevated liver chemistries. Abdominal enhanced computed tomography showed periportal and gallbladder wall edema. After cholecystectomy, the resected gallbladder was histologically considered to be a metastatic lesion arising from the primary lung cancer. The second case describes a case of a 77-year-old woman with multiple co-morbidities who presented to the hospital with sepsis secondary to biliary source. Abdominal enhanced computed tomography findings were concerning for acute cholecystitis. After cholecystectomy, the pathology of the resected gallbladder demonstrated cholecystitis and plasmacytoma. Conclusion: The atypical presentation of gallbladder metastases could mislead treating providers. The diagnosis might alter management decisions and prognosis.

scholarly journals Persistent hiccups as the presenting symptom of a pulmonary embolism

2012 ◽  
Vol 2 (1) ◽  
pp. 2
Author(s):  
Steven Durning ◽  
David J. Shaw ◽  
Anthony J. Oliva ◽  
Michael J. Morris
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Chest Radiograph ◽  
Pulmonary Embolus ◽  
Lower Lobe ◽  
Initial Evaluation ◽  
Unique Case ◽  
Case Presentation ◽  
History Of ◽  
Symptomatic Bradycardia

An 81-year-old male with a history of symptomatic bradycardia controlled by a pacemaker presented to our institution with three days of persistent hiccups. He denied any pulmonary symptoms and his initial evaluation showed no evidence of tachypnea, tachycardia, or hypoxia. Pacemaker malfunction or migration of the pacer leads was ruled out as an etiology and no intracranial pathology was present. Admission chest radiograph was normal but a computed tomography of the chest demonstrated a left lower lobe pulmonary embolus. After treatment with anticoagulation was initiated, the hiccups resolved within the next week. This is a unique case presentation of hiccups as the only presenting symptom of an otherwise asymptomatic pulmonary embolism.

scholarly journals When a road traffic accident leads to a skull metastasis from hepatocellular carcinoma: A unique case presentation

2020 ◽  
Vol 21 ◽  
pp. 100745
Author(s):  
Safwan O. Alomari ◽  
Abdelwahab J. Aeshawi ◽  
Omar Jbarah ◽  
Amer A. Jaradat ◽  
Mohammed Z. Allouh
Keyword(s):  
Hepatocellular Carcinoma ◽  
Road Traffic Accident ◽  
Traffic Accident ◽  
Road Traffic ◽  
Unique Case ◽  
Case Presentation ◽  
Skull Metastasis

scholarly journals Fenofibrate-Induced Lichenoid Drug Eruption: A Rare Culprit

2017 ◽  
Vol 9 (3) ◽  
pp. 236-242 ◽  
Author(s):  
Fayeza Mohammed ◽  
Laura L. Wally ◽  
Jeffrey E. Karaban ◽  
Vijaya B. Reddy ◽  
Yongsuk Lertratanakul
Keyword(s):  
Side Effect ◽  
Drug Eruption ◽  
Uv Exposure ◽  
Unique Case ◽  
Drug Eruptions ◽  
Familial Association ◽  
Rare Side Effect ◽  
Genetic Mechanisms ◽  
Appropriate Therapy ◽  
Clinically Significant

A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. In addition, we report a potential familial association which underscores the potential for underlying genetic mechanisms to be contributory to lichenoid drug eruptions. A reminder of the physical characteristics of lichen planus, knowledge of the temporal relation between administration of medications and a lichenoid drug eruption, recognition of the effect of UV exposure on lichenoid drug eruptions, and realization for the potential of symptoms to persist despite discontinuation of an offending agent can aid practitioners in promptly diagnosing lichenoid drug eruptions and initiating appropriate therapy.

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