scholarly journals Gallbladder Metastases: A Report of Two Cases

2019 ◽  
Vol 12 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Mohamad Mouchli ◽  
Douglas J. Grider ◽  
Paul Yeaton
Keyword(s):  
Computed Tomography ◽  
Invasive Ductal Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Primary Lung Cancer ◽  
Gallbladder Wall ◽  
Metastatic Lesion ◽  
Quadrant Pain ◽  
Case Presentation ◽  
Enhanced Computed Tomography

Introduction: Metastasis to the gallbladder is not common and usually manifests an advanced stage of malignancy. Herein, we report a case of triple negative high grade invasive ductal carcinoma of breast with a metastatic lesion to the gallbladder. Case Presentation: The patient is a 52-year-old female diagnosed with invasive ductal carcinoma treated with mastectomy and chemotherapy. After 12 months, she presented to the emergency department with right upper quadrant pain and elevated liver chemistries. Abdominal enhanced computed tomography showed periportal and gallbladder wall edema. After cholecystectomy, the resected gallbladder was histologically considered to be a metastatic lesion arising from the primary lung cancer. The second case describes a case of a 77-year-old woman with multiple co-morbidities who presented to the hospital with sepsis secondary to biliary source. Abdominal enhanced computed tomography findings were concerning for acute cholecystitis. After cholecystectomy, the pathology of the resected gallbladder demonstrated cholecystitis and plasmacytoma. Conclusion: The atypical presentation of gallbladder metastases could mislead treating providers. The diagnosis might alter management decisions and prognosis.

scholarly journals Ureteroscopy-Assisted Biopsy for a Retroperitoneal Tumor: A Case Report

2015 ◽  
Vol 8 (2) ◽  
pp. 279-284
Author(s):  
Yoko Maeda ◽  
Takashi Kawahara ◽  
Mikiko Tanabe ◽  
Yohei Kumano ◽  
Mari Ohtaka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Open Surgery ◽  
Retroperitoneal Fibrosis ◽  
Retroperitoneal Tumor ◽  
Idiopathic Retroperitoneal Fibrosis ◽  
Surgical Biopsy ◽  
Case Presentation ◽  
First Case ◽  
Open Surgical Biopsy ◽  
Enhanced Computed Tomography

Introduction: Retroperitoneal tumor is often seen in urology clinical practice. To diagnose the tumor, tumor specimens must be obtained. However, in some cases, the tumor is penetrated by vessels around the ureter, and it may be difficult to detect the optimal spot for obtaining a specimen, even when performing open surgery. Case Presentation: A 53-year-old male patient was referred to our hospital for further examination of left back pain due to hydronephrosis. Enhanced computed tomography demonstrated ureter stenosis in front of the ilium, which was surrounded by a retroperitoneal tumor. The tumor was penetrated by blood vessels; therefore, we performed an open surgical biopsy on the suspicion of a retroperitoneal tumor using ureteroscopic assistance. The diagnosis of idiopathic retroperitoneal fibrosis was made according to the biopsy. Conclusion: We herein report the first case of a ureteroscopy-assisted biopsy for the pathological diagnosis of a retroperitoneal tumor.

scholarly journals Main phenotypes and histological types of breast cancer in young women attended at a reference hospital in women’s health in the city of São Paulo

2020 ◽  
pp. BMT53
Author(s):  
Guilherme Moreno Rodrigues de Souza ◽  
Anderson Fernandes Carvalho ◽  
Simone Ferreira Santiago ◽  
Maria Aparecida M R Pinho ◽  
Débora Ribeiro Ramadan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Young Women ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Luminal B ◽  
High Prevalence ◽  
Reference Hospital ◽  
Triple Negative Phenotype ◽  
The City

It is estimated that there were 198,840 new cases of breast cancer (BC) in Brazil between 2020 and 2022. Young women who are affected by invasive BC with a triple-negative phenotype generally present more aggressive tumors that are intrinsically resistant to targeted therapies. This study evaluated the phenotypic and histological profile of BC in women up to the age of 40 years. Between 2015 and 2017, we identified 255 women with positive biopsy for carcinoma and with immunohistochemical panel, 51.76% who had a profile for luminal B (n = 132); 22.74% for triple-negative (n = 58). Of the samples, 65.88% presented histology as invasive ductal carcinoma – nonspecial type (n = 168). The results are in accordance with the literature regarding the high prevalence of triple-negative BC in young women and histological type invasive ductal carcinoma – nonspecial type.

scholarly journals Association of p53 expression with poor prognosis in patients with triple-negative breast invasive ductal carcinoma

Medicine ◽  
2019 ◽  
Vol 98 (18) ◽  
pp. e15449 ◽  
Author(s):  
Jing-ping Li ◽  
Xiang-mei Zhang ◽  
Zhenzhen Zhang ◽  
Li-hua Zheng ◽  
Sonali Jindal ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Poor Prognosis ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
P53 Expression ◽  
Breast Invasive Ductal Carcinoma

scholarly journals DCE-MRI Pharmacokinetic-Based Phenotyping of Invasive Ductal Carcinoma: A Radiomic Study for Prediction of Histological Outcomes

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Serena Monti ◽  
Marco Aiello ◽  
Mariarosaria Incoronato ◽  
Anna Maria Grimaldi ◽  
Michela Moscarino ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Outcome Prediction ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Tumor Grade ◽  
Imaging Biomarker ◽  
Diagnostic Tools ◽  
Dce Mri ◽  
Made In ◽  
Treatment Personalization

Breast cancer is a disease affecting an increasing number of women worldwide. Several efforts have been made in the last years to identify imaging biomarker and to develop noninvasive diagnostic tools for breast tumor characterization and monitoring, which could help in patients’ stratification, outcome prediction, and treatment personalization. In particular, radiomic approaches have paved the way to the study of the cancer imaging phenotypes. In this work, a group of 49 patients with diagnosis of invasive ductal carcinoma was studied. The purpose of this study was to select radiomic features extracted from a DCE-MRI pharmacokinetic protocol, including quantitative maps of ktrans, kep, ve, iAUC, and R1 and to construct predictive models for the discrimination of molecular receptor status (ER+/ER-, PR+/PR-, and HER2+/HER2-), triple negative (TN)/non-triple negative (NTN), ki67 levels, and tumor grade. A total of 163 features were obtained and, after feature set reduction step, followed by feature selection and prediction performance estimations, the predictive model coefficients were computed for each classification task. The AUC values obtained were 0.826±0.006 for ER+/ER-, 0.875±0.009 for PR+/PR-, 0.838±0.006 for HER2+/HER2-, 0.876±0.007 for TN/NTN, 0.811±0.005 for ki67+/ki67-, and 0.895±0.006 for lowGrade/highGrade. In conclusion, DCE-MRI pharmacokinetic-based phenotyping shows promising for discrimination of the histological outcomes.

scholarly journals Triple Negative Breast Cancer in Pregnancy and Postpartum: Two Case Reports in Hispanic Women

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ruchi Upadhyay ◽  
Qurat-Ul-Ain Butt ◽  
Abraham Hamaoui ◽  
Cassandra Henderson ◽  
Sydney McCalla ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Hispanic Women ◽  
African Ancestry ◽  
Radical Mastectomy ◽  
Unique Challenge ◽  
Pregnancy And Postpartum

Objective. Despite studies suggesting that triple negative breast cancer is more often seen in women of African ancestry, we report here two cases of pregnancy associated triple negative breast cancer in Hispanic women.Cases. Case one is a 37-year-old female para 2-0-0-2, who presented with a left breast mass, at 19 weeks of gestation, the biopsy of which reported an invasive ductal carcinoma, found to be triple receptor negative. The patient underwent chemotherapy during the pregnancy and was delivered with a cesarean at 37 weeks for obstetric indication. After delivery, the patient completed her chemotherapy that was followed by radical mastectomy and radiotherapy. Case two is a 28-year-old female para 6-0-1-5, who presented while breast-feeding with signs and symptoms of mastitis, and an engorged and tender right breast, five months postpartum. However, the sonogram revealed a fluid filled cavity. Aspiration and cytology did not reflect an infection and were negative for malignancy. High suspicion and lack of improvement led to biopsy that identified an invasive ductal carcinoma, found to be triple negative. The patient underwent chemotherapy followed by modified radical mastectomy.Conclusions. Triple negative breast cancer, during pregnancy or postpartum, poses a unique challenge and requires a multidisciplinary team to optimize treatment for these women.

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