scholarly journals Randomized controlled trial of exercise interventions to improve sleep quality and daytime sleepiness in individuals with multiple sclerosis: A pilot study

2016 ◽  
Vol 2 ◽  
pp. 205521731668063 ◽  
Author(s):  
Catherine F Siengsukon ◽  
Mayis Aldughmi ◽  
Melike Kahya ◽  
Jared Bruce ◽  
Sharon Lynch ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Randomized Controlled Trial ◽  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Controlled Trial ◽  
Moderate Intensity ◽  
Exercise Interventions ◽  
Moderate Improvement ◽  
Randomized Controlled ◽  
Improve Sleep Quality

Background Nearly 70% of individuals with multiple sclerosis (MS) experience sleep disturbances. Increasing physical activity in people with MS has been shown to produce a moderate improvement in sleep quality, and exercise has been shown to improve sleep quality in non-neurologically impaired adults. Objective The purpose of this pilot randomized controlled trial study was to examine the effect of two exercise interventions on sleep quality and daytime sleepiness in individuals with MS. Methods Twenty-eight individuals with relapsing–remitting or secondary progressive MS were randomized into one of two 12-week exercise interventions: a supervised, moderate-intensity aerobic exercise (AE) program or an unsupervised, low-intensity walking and stretching (WS) program. Only individuals who were ≥ 70% compliant with the programs were included in analysis ( n = 12 AE; n = 10 WS). Results Both groups demonstrated a moderate improvement in sleep quality, although only the improvement by the WS group was statistically significant. Only the AE group demonstrated a significant improvement in daytime sleepiness. Change in sleep quality and daytime sleepiness was not correlated with disease severity or with change in cardiovascular fitness, depression, or fatigue. Conclusion The mechanisms for improvement in sleep quality and daytime sleepiness need further investigation, but may be due to introduction of zeitgebers to improve circadian rhythm.

scholarly journals Music to improve sleep quality in adults with depression-related insomnia (MUSTAFI): study protocol for a randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Helle Nystrup Lund ◽  
Inge Nygaard Pedersen ◽  
Søren Paaske Johnsen ◽  
Agnieszka M. Heymann-Szlachcinska ◽  
Maryla Tuszewska ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Sleep Quality ◽  
Study Protocol ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Improve Sleep Quality

scholarly journals The Effect of Foot Reflexology on Fatigue, Sleep Quality and Anxiety in Patients with Multiple Sclerosis: A Randomized Controlled Trial

2020 ◽  
Vol 7 (3) ◽  
Author(s):  
Mahbobeh Sajadi ◽  
Fahimeh Davodabady ◽  
Mohsen Ebrahimi-Monfared
Keyword(s):  
Multiple Sclerosis ◽  
Randomized Controlled Trial ◽  
Sleep Quality ◽  
Controlled Trial ◽  
Nursing Intervention ◽  
Physical Fatigue ◽  
Randomized Controlled ◽  
Impact Scale ◽  
Fatigue Impact Scale

Background: Fatigue, sleep disorders, and anxiety are common symptoms in multiple sclerosis (MS) patients. MS reduced the quality of life by these symptoms in patients. Studies have shown that foot reflexology may reduce some problems of this disease. Objectives: The present randomized controlled trial study investigated the effect of reflexology on fatigue, sleep quality, and anxiety in patients with multiple sclerosis. Methods: This study included 63 patients with MS referred to Arak MS society in 2018 - 2019. Reflexology and placebo intervention had applied twice a week for 4 weeks, and each session lasted about 30 - 40 minutes. Fatigue Impact scale (FIS), Pittsburgh sleep quality index (PSQI) and state-trait anxiety inventory (STAI) was used for data collection before and after the intervention. A significant statistical level was considered 0.05. Data were analyzed using the SPSS software (V. 16.0). Results: Significant improvement was observed in physical fatigue (P = 0.042), sleep quality (P = 0.001) and anxiety (P = 0.034) in the reflexology group after the intervention. Fatigue Impact Scale (FIS) revealed a decrease in fatigue level in MS patients, but these alterations were not significant (P = 0.134). Conclusions: Reflexology is a non-invasive, simple, affordable, and low-cost nursing intervention that can be helpful in reducing physical fatigue, anxiety, and improving sleep quality of people with MS.

scholarly journals Home exercise improves the quality of sleep and daytime sleepiness of elderlies: a randomized controlled trial

2018 ◽  
Vol 13 ◽  
Author(s):  
Glauber Sá Brandão ◽  
Glaucia Sá Brandão Freitas Gomes ◽  
Glaudson Sá Brandão ◽  
Antônia A. Callou Sampaio ◽  
Claudio F. Donner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Randomized Controlled Trial ◽  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Controlled Trial ◽  
Exercise Program ◽  
Home Exercise ◽  
Quality Of Sleep ◽  
Randomized Controlled

Background: Aging causes physiological changes which affect the quality of sleep. Supervised physical exercise is an important therapeutic resource to improve the sleep of the elderlies, however there is a low adherence to those type of programs, so it is necessary to implement an exercise program which is feasible and effective. The study aimed to test the hypothesis that a semi-supervised home exercise program, improves sleep quality and daytime sleepiness of elderlies of the community who present poor sleep quality. Methods: This was a randomized controlled trial study, conducted from May to September 2017, in Northeastern Brazil, with elderlies of the community aging 60 years old or older, sedentary, with lower scores or equal to 5 at the Pittsburgh Sleep Quality Index (PSQI) and without cognitive decline. From one hundred ninety-one potential participants twenty-eight refused to participate, therefore, one hundred thirty-one (mean age 68 ± 7 years), and 88% female, were randomly assigned to an intervention group - IG (home exercise and sleep hygiene, n = 65) and a control group - CG (sleep hygiene only, n = 66). Sleep assessment tools were used: PSQI, Epworth sleepiness scaleA (ESS) and clinical questionnaire of Berlin. The level of physical activity has been assessed by means of International Physical Activity Questionnaire adapted for the elderly (IPAQ) and Mini-Mental State Examination for cognitive decline. All participants were assessed before and after the 12-week intervention period and, also, the assessors were blind. Results: The IG showed significant improvement in quality of sleep with a mean reduction of 4.9 ± 2.7 points in the overall PSQI (p < 0.01) and in all its 7 components of evaluation (p < 0.05), and improvement of secondary endpoint, daytime sleepiness, a decline of 2.8 ± 2.2 points in the ESS (p < 0.01). Conclusion: Our results suggest that semi-supervised home exercise is effective in improving the quality of sleep and self-referred daytime sleepiness of sedentary elderlies of the community who presented sleep disorders.

Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis

2013 ◽  
Vol 20 (5) ◽  
pp. 594-601 ◽  
Author(s):  
LA Pilutti ◽  
D Dlugonski ◽  
BM Sandroff ◽  
R Klaren ◽  
RW Motl
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Randomized Controlled Trial ◽  
Sleep Quality ◽  
Behavioral Intervention ◽  
Behavioral Interventions ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Related Quality ◽  
Lifestyle Physical Activity

Background: Exercise training is beneficial, but most persons with multiple sclerosis (MS) are sedentary and physically inactive. This has prompted a new focus on the promotion of lifestyle physical activity in MS. We previously designed, tested, and refined a behavioral intervention delivered through the Internet that successfully increased lifestyle physical activity in MS, but have not evaluated the effects on secondary symptomatic and health-related quality of life (HRQOL) outcomes. Objective: We conducted a 6-month randomized controlled trial (RCT) that examined the efficacy of an Internet-delivered, behavioral intervention for improving outcomes of fatigue, depression, anxiety, pain, sleep quality, and HRQOL in 82 ambulatory persons with MS. The secondary aim was to replicate previous results regarding change in free-living physical activity. Results: There was a significant and positive effect of the intervention on fatigue severity ( p=.001, ηρ2=.15) and its physical impact ( p=.008, ηρ2=.09), depression ( p=.006, ηρ2=.10), and anxiety ( p=.006, ηρ2=.10). There were non-significant improvements in pain ( p=.08, ηρ2=.04), sleep quality ( p=.06, ηρ2=.05), and physical HRQOL ( p=.06, ηρ2=.05). We replicated our previous results by demonstrating an increase in self-reported physical activity ( p=.001, ηρ2=.13). Conclusions: Our results support behavioral interventions targeting lifestyle physical activity as an alternative approach for managing symptoms in MS.

531 Efficacy of a physical activity intervention for managing restless legs syndrome in multiple sclerosis: A pilot RCT

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A209-A209
Author(s):  
Katie Cederberg ◽  
Robert Motl
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Randomized Controlled Trial ◽  
Sleep Quality ◽  
Restless Legs Syndrome ◽  
Physical Activity Intervention ◽  
Controlled Trial ◽  
Restless Legs ◽  
Positive Effects ◽  
Randomized Controlled

Abstract Introduction Restless legs syndrome (RLS) occurs in approximately 26% of persons with multiple sclerosis (MS) and can worsen other symptoms of MS, including sleep quality. Physical activity represents a promising approach for managing RLS and its secondary effects in MS. This pilot randomized controlled trial examined the feasibility and efficacy of a physical activity intervention for improving RLS severity and secondary sleep outcomes among a sample of adults with MS. Methods Participants with MS (N=15) were randomly assigned into intervention (n=8) or waitlist control (n=7) conditions. The physical activity behavioral intervention was delivered over a 16-week period and outcomes were assessed at baseline and immediately following the 16-week period in both conditions. Results There was a significant, positive effect of the intervention on overall RLS severity (p=.01;ηρ2=.43), RLS severity during the night (p=.03,ηρ2=.35), RLS severity during the day while resting (p=.01,ηρ2=.44), and RLS severity during the day while active (p&lt;.01,ηρ2=.61), and non-significant improvements in RLS severity while falling asleep (p=.33,ηρ2=.09). There were significant positive effects on sleep satisfaction (p&lt;.01,ηρ2=.49) and non-significant improvements in self-reported global sleep quality (p=.35,ηρ2=.08). There was a significant intervention effect on self-reported time in bed (p=.03,ηρ2=.37) and total sleep time (p=.03,ηρ2=.36), and non-significant improvements in self-reported sleep latency (p=.08,ηρ2=.25), sleep efficiency (p=.27,ηρ2=.11), and daytime sleepiness (p=.52,ηρ2=.04; p=.35,ηρ2=.08; p=.51,ηρ2=.04). There was no significant effect of the intervention on device-measured sleep quality. Conclusion This study provides initial evidence for the feasibility and efficacy of a physical activity intervention for reducing RLS severity and possibly self-reported sleep quality outcomes in persons with MS. These preliminary results should inform a future, fully-powered randomized controlled trial that further establishes the efficacy of physical activity for reducing symptoms of RLS and secondary outcomes in a larger sample of adults with MS and RLS. Support (if any) This work was supported, in part, by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health [F31HD097903]. ClinicalTrials.gov Identification Number: NCT0406168.

scholarly journals Cognitive Effects of Aerobic Exercise in Alzheimer’s Disease: A Pilot Randomized Controlled Trial

2021 ◽  
pp. 1-12
Author(s):  
Fang Yu ◽  
David M. Vock ◽  
Lin Zhang ◽  
Dereck Salisbury ◽  
Nathaniel W. Nelson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Controlled Trial ◽  
Moderate Intensity ◽  
Cognitive Effects ◽  
Data Set ◽  
Randomized Controlled

Background: Aerobic exercise has shown inconsistent cognitive effects in older adults with Alzheimer’s disease (AD) dementia. Objective: To examine the immediate and longitudinal effects of 6-month cycling on cognition in older adults with AD dementia. Methods: This randomized controlled trial randomized 96 participants (64 to cycling and 32 to stretching for six months) and followed them for another six months. The intervention was supervised, moderate-intensity cycling for 20–50 minutes, 3 times a week for six months. The control was light-intensity stretching. Cognition was assessed at baseline, 3, 6, 9, and 12 months using the AD Assessment Scale-Cognition (ADAS-Cog). Discrete cognitive domains were measured using the AD Uniform Data Set battery. Results: The participants were 77.4±6.8 years old with 15.6±2.9 years of education, and 55%were male. The 6-month change in ADAS-Cog was 1.0±4.6 (cycling) and 0.1±4.1 (stretching), which were both significantly less than the natural 3.2±6.3-point increase observed naturally with disease progression. The 12-month change was 2.4±5.2 (cycling) and 2.2±5.7 (control). ADAS-Cog did not differ between groups at 6 (p = 0.386) and 12 months (p = 0.856). There were no differences in the 12-month rate of change in ADAS-Cog (0.192 versus 0.197, p = 0.967), memory (–0.012 versus –0.019, p = 0.373), executive function (–0.020 versus –0.012, p = 0.383), attention (–0.035 versus –0.033, p = 0.908), or language (–0.028 versus –0.026, p = 0.756). Conclusion: Exercise may reduce decline in global cognition in older adults with mild-to-moderate AD dementia. Aerobic exercise did not show superior cognitive effects to stretching in our pilot trial, possibly due to the lack of power.

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