scholarly journals Synthesis and properties of Sr2+ doping α-tricalcium phosphate at low temperature

2021 ◽  
Vol 19 ◽  
pp. 228080002199699
Author(s):  
Zhen Yuan ◽  
Jianqiang Bi ◽  
Weili Wang ◽  
Xiaoning Sun ◽  
Lu Wang ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Low Temperature ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Setting Time ◽  
Cell Activity ◽  
Repair Materials ◽  
Calcium Phosphate Bone Cement ◽  
Bone Repair Materials ◽  
Osteoclast Apoptosis

Strontium has been widely used in bone repair materials due to its roles in promoting osteoclast apoptosis and enhancing osteoblast proliferation. In this work, synthesis and the effects of Sr2+ doping α-tricalcium phosphate at low-temperature was studied. The setting time and the mechanical properties of α-tricalcium phosphate were controlled by varying the content of Sr2+. The synthesized compounds were evaluated by XRD, SEM, XPS, setting time, compressive strength, SBF immersion, and colorimetric CCK-8 assay. The results showed that Sr2+ can improve the compressive strength and cell activity of calcium phosphate bone cement.

scholarly journals Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties

RSC Advances ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 781-789 ◽  
Author(s):  
Lu Xie ◽  
Yuanyi Yang ◽  
Zhiqiang Fu ◽  
Yunfei Li ◽  
Jiacheng Shi ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Biological Properties ◽  
Synthetic Bone ◽  
Repair Materials ◽  
Bone Repair Materials

Fe/Zn-TCP biomaterials were prepared and their bioactivities to enhance the synthetic bone-repair materials were studied in comparison.

Multi-stage controllable degradation of strontium-doped calcium sulfate hemihydrate-Tricalcium phosphate microsphere composite as a substitute for osteoporotic bone defect repairing: Degradation behavior and bone response

2021 ◽  
Author(s):  
Qiuju Miao ◽  
Nan Jiang ◽  
Qinmeng Yang ◽  
Ismail mohamed Hussein ◽  
Zhen Luo ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Calcium Sulfate ◽  
Bone Repair ◽  
Degradation Rate ◽  
Bone Defects ◽  
Osteoporotic Bone ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
In Vivo Degradation

Abstract Various requirements for the repair of complex bone defects have motivated to development of scaffolds with adjustable degradation rates and biological functions. Tricalcium phosphate and calcium sulfate are the most commonly used bone repair materials in the clinic, how to better combine tricalcium phosphate and calcium sulfate and play their greatest advantages in the repair of osteoporotic bone defect is the focus of our research. In this study, a series of scaffolds with multistage-controlled degradation properties composed of strontium-doped calcium sulfate (SrCSH) and strontium-doped tricalcium phosphate microspheres (Sr-TCP) scaffolds were prepared, and their osteogenic activity, in vivo degradation and bone regeneration ability in tibia of osteoporotic rats were evaluated. In vitro studies revealed that different components of SrCSH/Sr-TCP scaffolds significantly promoted the proliferation and differentiation of MC3T3-E1 cells, which showed a good osteogenic induction activity. In vivo degradation results showed that the degradation time of composite scaffolds could be controlled in a large range (6-12 months) by controlling the porosity and phase composition of Sr-TCP microspheres. The results of osteoporotic femoral defect repair showed that when the degradation rate of scaffold matched with the growth rate of new bone, the parameters such as BMD, BV/TV, Tb.Th, angiogenesis marker CD31 and new bone formation marker OCN expression were higher, which promoted the rapid repair of osteoporotic bone defects. On the contrary, the slow degradation rate of scaffolds hindered the growth of new bone to a certain extent. This study elucidates the importance of the degradation rate of scaffolds for the repair of osteoporotic bone defects, and the design considerations can be extended to other bone repair materials, which is expected to provide new ideas for the development of tissue engineering materials in the future.

Preparation and Properties of Injectable Hydroxyapatite for Bone Repair Materials

2010 ◽  
Vol 434-435 ◽  
pp. 590-593
Author(s):  
Hua Liu ◽  
Xiao Feng Chen ◽  
Chang Ren Zhou
Keyword(s):  
Liquid Phase ◽  
Bone Repair ◽  
Solid Phase ◽  
Setting Time ◽  
Chitosan Solution ◽  
Hydration Reaction ◽  
Liquid Ratio ◽  
Repair Materials ◽  
Bone Repair Materials

The aim of this study was to develop a novel injectable hydroxyapatite for bone repair materials. This study was based on the in situ setting properties of calcium phosphate cement (CPC), which properties were improved. The solid phase consisted of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA). The liquid phase was the weak acidic solution of chitosan. The CPC powder was mixed with the chitosan solution to form a paste that could conform to the bone cavity even for irregularly shaped cavities. All the by-production disappeared by neutralization reaction. The CPC paste could then set in situ to form hydroxyapatite (HA) as the final product. The chemical process of CPC hydration was studied. The process was controlled by dissolution and precipitation chemical reaction. The kinetic model of hydration reaction was established. The effects of preparing conditions, such as powder to liquid ratio and particle size, on setting time and compressive strength were investigated systematically. The optimal condition was that the liquid phase contained 3% chitosan, 5% citric acid and 15% glucose (wt%), powder to liquid ratio was 0.8 g/ml, and powders were respectively ground for 40 hours.

scholarly journals A Novel Fast-Setting Strontium-Containing Hydroxyapatite Bone Cement With a Simple Binary Powder System

2021 ◽  
Vol 9 ◽  
Author(s):  
Lijuan Sun ◽  
Tongyang Li ◽  
Sen Yu ◽  
Mengmeng Mao ◽  
Dagang Guo
Keyword(s):  
Compressive Strength ◽  
Bone Cement ◽  
Setting Time ◽  
Synthesis Temperature ◽  
Transformation Rate ◽  
Step Method ◽  
Cement Powder ◽  
Calcium Phosphate Bone Cement ◽  
One Step ◽  
Application Potential

In recent years, strontium-substituted calcium phosphate bone cement (Sr-CPC) has attracted more and more attentions in the field of bone tissue repair due to its comprehensive advantages of both traditional CPC and Sr ions. In this study, a crucial Sr-containing α-Ca3–xSrx(PO4)2 salt has been synthesized using a simplified one-step method at lower synthesis temperature. A novel Sr-CPC has been developed based on the simple binary Sr-containing α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder. The physicochemical properties and hydration mechanism of this Sr-CPC at various Sr contents were intensively investigated. The setting product of this Sr-CPC after a set for 72 h is a single-phase Sr-containing hydroxyapatite, and its compressive strength slightly decreased and its setting time extended with the increase of Sr content. The hydration process included the initial formation of the medium product CaHPO4⋅2H2O (30 min∼1 h), the following complete hydration of Ca4(PO4)2O and the initially formed CaHPO4⋅2H2O (2∼6 h), and the final self-setting of α-Ca3–xSrx(PO4)2 (6 h∼). The compressive strength of Sr-CPC, which was closely related to the transformation rate of Sr-containing hydroxyapatite, tended to increase with the extension of hydration time. In addition, Sr-CPC possessed favorable cytocompatibility and the effect of Sr ions on cytocompatibility of Sr-CPC was not obvious at low Sr contents. The present study suggests α-Ca3–xSrx(PO4)2 is a kind of vital Sr-containing salt source which is useful to develop some novel Sr-containing biomaterials. In addition, the new Sr-containing cement system based on this simple binary α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder displayed an attractive clinical application potential in orthopedics.

Effect of Metakaolin on Geopolymer Industry

2019 ◽  
pp. 49-70
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Flexural Strength ◽  
Reaction Mechanisms ◽  
Ordinary Portland Cement ◽  
Setting Time ◽  
Experimental Studies ◽  
Acid Attack ◽  
Repair Materials ◽  
Hardened State

This chapter discusses the effects of metakaolin (MK) on geopolymer mortar and concrete industries. The research topics of MK-based geopolymer cover reaction mechanisms and kinetics. This chapter aims at augmenting knowledge about enhancing mechanical properties of geopolymer mortars/concrete using MK. Specifically, this chapter presents literature studies as well as current experimental studies which delineate the effect of MK on fresh and hardened-state properties of geopolymer mortars (GPMs). Properties and characteristics of metakaolin are explained followed by properties of fresh MK mortars. Properties of hardened MK concrete and durability aspects of MK mortars are explained. Applications of MK-based geopolymers and metakaolin-based geopolymers as repair materials are also included in this chapter. The results of using MK-based GPMs revealed improved workability, enhanced setting time, increased density, higher compressive strength, flexural strength, and resistance against acid attack than conventional ordinary portland cement mortar/concrete.

Peptide‐modified bone repair materials: Factors influencing osteogenic activity

2019 ◽  
Vol 107 (7) ◽  
pp. 1491-1512 ◽  
Author(s):  
Jie Liao ◽  
Shuai Wu ◽  
Kun Li ◽  
Yubo Fan ◽  
Nicholas Dunne ◽  
...  
Keyword(s):  
Bone Repair ◽  
Osteogenic Activity ◽  
Factors Influencing ◽  
Repair Materials ◽  
Bone Repair Materials

Preparation and characterization of a novel hydroxyapatite-wollastonite/silk fibroin composite

2011 ◽  
Vol 46 (13) ◽  
pp. 1571-1581 ◽  
Author(s):  
Song Zhao ◽  
Zhufa Zhou ◽  
Jiang Wu ◽  
Shumei Wang ◽  
Xinshuang Guo ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Low Temperature ◽  
Simulated Body Fluid ◽  
Silk Fibroin ◽  
Body Fluid ◽  
Bone Repair ◽  
Coprecipitation Method ◽  
Ft Ir ◽  
Low Crystallinity

A novel hydroxyapatite-wollastonite/silk fibroin (AW/SF) composite was prepared for bone repair and replacement by a modified coprecipitation method. The wollastonite powders introduced in the composite were sintered with full crytallinity and ground to the diameter of 30–50 nm. The FT-IR and XRD analyses showed that the silk fibroin, wollastonite, and hydroxyapatite co-existed in the composite, but the newly formed hydroxyapatite had low crystallinity ascribing to the low temperature procedure. The composite exhibited both higher compressive strength (84.4 MPa) and Barcol hardness (48.5) than the hydroxyapatite/silk fibroin (HA/SF) composite without any wallostonite involved. And the composite in this work showed excellent bioactivities while held in simulated body fluid (SBF).

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