scholarly journals Neutrophilic Dermatosis in Myelodysplastic Syndrome and Chronic Active Hepatitis C

2021 ◽  
Vol 9 ◽  
pp. 232470962110374
Author(s):  
Rupam Sharma ◽  
Royce H. Johnson ◽  
Arash Heidari ◽  
Matthew Malerich ◽  
William R. Stull ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Early Diagnosis ◽  
Myelodysplastic Syndrome ◽  
Chronic Active Hepatitis ◽  
Clinical Laboratory ◽  
Neutrophilic Dermatosis ◽  
Hepatitis C Infection ◽  
Sweet Syndrome ◽  
Systemic Glucocorticoids ◽  
Histological Characteristics

In this article, we describe a case of neutrophilic dermatosis of the dorsal hands (NDDH) complicated with myelodysplastic syndrome and chronic active hepatitis C infection. NDDH was first suggested by Galaria et al in 2000. After comparing features of NDDH with Sweet syndrome in terms of encompassing clinical, laboratory, and histological characteristics, it can be concluded that “distributional or localized variant” of Sweet syndrome is classified as NDDH. Early diagnosis and treatment can improve prognosis. Systemic glucocorticoids are the mainstay of treatment.

scholarly journals Cryoglobulinemia and sensorimotor polyneuropathy

2020 ◽  
Vol 40 (1) ◽  
pp. 35-37
Author(s):  
Marija Sedlić ◽  
Gordana Sičaja ◽  
Krešimir Luetić ◽  
Hrvoje Budinčević
Keyword(s):  
Hepatitis C ◽  
Peripheral Neuropathy ◽  
Early Diagnosis ◽  
Neurological Manifestations ◽  
Hepatitis C Infection ◽  
Skin Changes ◽  
Sensorimotor Polyneuropathy ◽  
Extrahepatic Manifestation

Secondary cryoglobulinemia is the most common extrahepatic manifestation of hepatitis C. There are different genotypes of hepatitis C, and the ones that are most frequently associated with cryoglobulinemia are genotypes 1b and 2a. Cryoglobulinemia affects various organs and can cause vasculitis, arthralgia, skin changes, glomerulonephritis and neurological manifestations, including peripheral neuropathy. The aim of this report was to emphasize the importance of early diagnosis of hepatitis C infection in patients who are presenting with sensomotor polyneuropathy.

scholarly journals Persistent oxidative stress in patients with chronic active hepatitis-C infection after antiviral therapy failure

2012 ◽  
Vol 18 (6) ◽  
pp. 375 ◽  
Author(s):  
Ghada El Kannishy ◽  
Mona Arafa ◽  
Ibrahim Abdelaal ◽  
Mohamed Elarman ◽  
Rasha El Mahdy
Keyword(s):  
Oxidative Stress ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Active Hepatitis ◽  
Hepatitis C Infection ◽  
Therapy Failure

scholarly journals Clinical and histological characteristics of HIV and hepatitis C virus-co-infected patients in Brazil: a case series study

2008 ◽  
Vol 50 (4) ◽  
pp. 213-217 ◽  
Author(s):  
Maria Cássia Mendes-Correa ◽  
Azzo Widman ◽  
Maria Luiza Paes Brussi ◽  
Cristina Fátima Guastini ◽  
Norma de Paula Cavalheiro ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Case Series ◽  
Hepatitis C Infection ◽  
Cell Counts ◽  
Case Series Study ◽  
History Of ◽  
Histological Characteristics ◽  
Normal Alt

Hepatitis C virus (HCV) is an important factor contributing to morbidity and mortality in patients co-infected with HIV and HCV. In addition, liver biopsy is an important tool in the clinical management of these patients. Although liver biopsy is controversial, it is recommended for all patients. Data regarding the clinical and histological characteristics of these patients are scarce not only in Brazil but in Latin America as a whole. With the goal of better understanding these characteristics and the benefit of liver biopsy indications in this disease setting, data collected from 234 patients followed from 1996 to 2004 at Casa da AIDS, São Paulo, were analyzed. The following variables were extracted from the patients' medical files at the time of liver biopsy: sex, age, hepatitis C infection risk factors, hepatitis C infection duration, ALT levels, CD4+ T cell counts, history of alcohol abuse, history of antiretroviral therapy, HCV genotype, and liver histological alterations. CONCLUSIONS: 1 - Hepatitis C virus 1 and 3 were the most frequently identified genotypes and were diagnosed in 72% and 25.5% of cases respectively; 2 - Structural liver alterations were found to be mild or absent in 48.2% (113/234) of the analyzed patients; 3 - Fifty-three patients (23%) had normal ALT levels and 4 - Significant liver architectural changes (F2-F3) were evident in 22.5% of the patients with normal ALT levels.

scholarly journals Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing sweet syndrome

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Olga Vera-Lastra ◽  
Arturo Olvera-Acevedo ◽  
Nancy Pulido-Díaz ◽  
Marissa de Jesús Quintal-Ramírez ◽  
Irvin Ordoñez-González ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Unusual Case ◽  
Fatal Outcome ◽  
Neutrophilic Dermatosis ◽  
Sweet Syndrome ◽  
Acute Febrile Neutrophilic Dermatosis ◽  
Inflammatory Skin Disorder ◽  
Acute Myeloid

The Sweet’s syndrome, is an inflammatory skin disorder characterized by extensive infiltration of neutrophils in the dermis with extension to the subcutis, known as acute febrile neutrophilic dermatosis. It may occur as a paraneoplastic syndrome. To our knowledge, there are currently few reports about transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet syndrome in the literature. Herein we describe an unusual case in a young patient with these characteristics that evolved to a fatal outcome.

scholarly journals HEPATITIS C

2009 ◽  
Vol 16 (02) ◽  
pp. 169-172
Author(s):  
FAQIR MUHAMMAD TARIQ ◽  
IRSHAD AHMAD ◽  
HABIB SUBHANI ◽  
Irshad Ul Haq
Keyword(s):  
Hepatitis C ◽  
Clinical Laboratory ◽  
Age Distribution ◽  
Step Test ◽  
Public Health Issue ◽  
Hepatitis C Infection ◽  
Staff Members ◽  
Paramedical Staff ◽  
Retrospective Audit ◽  
Department Of Ophthalmology

I n t r o d u c t i o n : Hepatitis C is a RNA virus isolated in 1988 but still not cultured in the laboratory. Hepatitis-C infection is aserious global public health issue, WHO estimates worlds 3 % population is HCV positive. Pakistan is also facing the huge burden of thisdisease. Accurate prevalence information for hepatitis C infection is scant in Pakistan. Few population based studies are available, the mostcomprehensive being that of Luby et al which after testing a representative sample from a population of 150,000 in Hafizabad, Pakistanfound an overall sero-prevalence of 6%. This increased to 30% with increasing age. They also found sero-prevalence of 16% in householdmembers of HCV infected cases. Aslam et al reported a population prevalence of 16% from Lahore and 23.8% in Gujranwala. In our studypublished in Medical Forum showed prevalence of HCV antibodies in population attending our department of ophthalmology is 27.06%.There is no data from Pakistan about prevalence of hepatitis C in Paramedical staff. It appears that paramedical staff is at higher risk ofcontracting this infection as they are exposed to multiple risk factors like needle stick injuries. Little is known about the prevalence of HepatitisC in this group of population. The objective of our study was to assess the perceived increased incidence of Hepatitis C in this group ofpopulation. M e t h o d s & Materials:This is a retrospective audit of the data from the records kept by clinical laboratory of University MedicalCollege, Faisalabad. All paramedical staff members were invited for HCV antibody test on 13.1.2007 to 20.1.2007.Any staff member workingin those days was included in the study. Persons on holidays or did not give free informed consent was excluded from the study. Serumof blood samples were analyzed by EXCEL a one step test device for the qualitative detection of antibodies to Hepatitis C virus in serumor plasma by trained professional. This test has a relative sensitivity of 96.8%, relative specificity 99% and accuracy 98.9% as comparedto HCV EIA test. Statistical analysis was performed by SPSS system.Results: A total 80 staff members were working in the hospital at thattime, 61 attended for the test (F: 31, M: 30). We found 7 (11.4%) were HCV positive and 54 (88.52%) were HCV negative including 2 weeklypositive. Among HCV positive 4 (6.55%) were male and 3 (4.91 %) were females. Age distribution was 17 - 75 years with mean age 32.51years. Among HCV positive 3 were analyzed by ELISA technique. 2 weekly positive by EXCEL were negative by ELISA and 1 positive byEXCEL was positive by ELISA. C o n c l u s i o n : Paramedical staff is perhaps not at higher risk of contracting HCV infection. However morestudies are required to further assess this finding.

Sweet Syndrome in a Patient with Chronic Hepatitis C

2014 ◽  
Vol 18 (6) ◽  
pp. 436-468 ◽  
Author(s):  
Danny Guo ◽  
Laurie M. Parsons
Keyword(s):  
Drug Reaction ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Agents ◽  
Skin Condition ◽  
Hepatitis C Infection ◽  
Sweet Syndrome

Background: Sweet syndrome (SS) is a rare skin condition that is classically idiopathic in etiology, but can also be triggered by malignancy, drug reaction, or infection. Both chronic hepatitis C infection and antiviral agents for the treatment of hepatitis C have been postulated to be possible triggers of SS. Objective: Herein, we present a case of SS in a patient with untreated chronic hepatitis C and cirrhosis but no other significant comorbidities.

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
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