scholarly journals Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients

2020 ◽  
Vol 12 ◽  
pp. 251584142095168
Author(s):  
Ramazan Kürşad Zor ◽  
Serpil Erşan ◽  
Erkut Küçük ◽  
Gamze Yıldırım ◽  
İsmail Sarı
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Age Related

Purpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants ( n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group ( p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group ( p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.

scholarly journals MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) CONCENTRATIONS IN CARRAGEENAN-INDUCED GASTROENTEROCOLITIS

2017 ◽  
pp. 64-67
Author(s):  
A. S. Tkachenko ◽  
O. A. Nakonechnaya ◽  
T. V. Gorbach ◽  
A. I. Onischenko ◽  
T. N. Chubukova
Keyword(s):  
Oxidative Stress ◽  
Blood Serum ◽  
Proinflammatory Cytokine ◽  
Food Additive ◽  
Control Group ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Tnf Α

Aim: to study MCP-1 concentrations in chronic carrageenan-induced gastroenterocolitis and the role of this protein in the development and progression of the disease. Material and methods . Thirty female WAG rats were divided into three groups (each group consisted of ten individuals): 1) introduction of 1% carrageenan solution for 14 days; 2) introduction of 1 % carrageenan solution for 28 days; 3) the control group. The animals of the first two groups were developing gastroenterocolitis. The MCP-1 and TNF-α concentrations were measured in the blood serum by ELISA. Results. Development of carrageenan-induced gastroenterocolitis was accompanied by increased levels of both MCP-1 and TNF-α in the blood serum. The level of the increase of both the parameters was more evident after four-week oral taking of the food additive carrageenan. Conclusion. The increased MCP-1 production in carrageenan-induced gastroenterocolitis may be directly due to the toxic effect of carrageenan on the macrophages of the gastrointestinal tract, development of oxidative stress, as well as due to the stimulating effect of the proinflammatory cytokine TNF-α.

The Effect of Immunosuppression on Selected Antioxidant Parameters in Patients with Graves’ Disease with Active Thyroid-Associated Orbitopathy

2020 ◽  
Author(s):  
Magdalena Londzin-Olesik ◽  
Beata Kos-Kudla ◽  
Jacek Karpe ◽  
Aleksandra Nowak ◽  
Mariusz Nowak
Keyword(s):  
Oxidative Stress ◽  
Clinical Symptoms ◽  
Immunosuppressive Treatment ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Paraoxonase 1 ◽  
Control Group ◽  
Graves Disease ◽  
Methylprednisolone Treatment ◽  
Antioxidant Parameters

Abstract Background and Study Aims Thyroid-associated orbitopathy, the most common extrathyroidal manifestation of Graves’ disease, is an autoimmune inflammation of orbital soft tissue. We report the study assessing the effect of immunosuppressive treatment with methylprednisolone on selected antioxidant parameters in patients with Graves’ disease with active thyroid-associated orbitopathy. Patients and Methods Activity and serum levels of selected antioxidant parameters as well as lipid peroxidation products were determined in a group of 56 patients with active thyroid-associated orbitopathy at three time-points: at baseline, after the discontinuation of intravenous methylprednisolone treatment and at 3 months after the discontinuation of additional oral methylprednisolone treatment. A control group consisted of 20 healthy age- and sex-matched volunteers. Results We found an increased activity of superoxide dismutase and glutathione peroxidase and increased serum levels of uric acid, malondialdehyde and conjugated dienes, as well as a reduced activity of paraoxonase-1 and reduced serum vitamin C level in the study group at baseline. Systemic intravenous and oral methylprednisolone therapy led to normalization of activity and concentration of the most studied parameters. Conclusion Results of our study confirmed that oxidative stress is one of the factors involved in the pathogenesis of thyroid-associated orbitopathy and the methyloprednisolone treatment is effective in reducing both clinical symptoms and oxidative stress in patients with this disease.

Monocyte chemoattractant protein-1 serum levels in ovarian cancer patients

1999 ◽  
Vol 35 ◽  
pp. S242
Author(s):  
L. Hefler ◽  
C. Tempfer ◽  
G. Heinze ◽  
S. Leodolter ◽  
G. Sliutz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Role of monocyte chemoattractant protein-1, stromal derived factor-1 and retinoic acid in pathophysiology of neuropathic pain in rats

2016 ◽  
Vol 27 (4) ◽  
Author(s):  
Enas Ahmed Hamed ◽  
Hanan Sayed Mohamed Farghaly ◽  
Asmaa Fathey Abdel Mola ◽  
Minerva Kamal Fahmi ◽  
Madiha Mohammed Makhlouf ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Retinoic Acid ◽  
Sciatic Nerve ◽  
Pain Treatment ◽  
Serum Levels ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Stromal Cell Derived Factor

AbstractChemokines have been recently recognized to play a role in chronic pain syndromes’ pathophysiology. This study investigated the role of monocyte chemoattractant protein-1 (MCP-1), stromal cell derived factor-1 (SDF-1), and retinoic acid (RA) as targets for the therapeutic approach of neuropathic pain.A chronic constriction injury (CCI) model of neuropathic pain by unilateral ligation of left sciatic nerve was performed in adult female Wistar rats. The effects of doxycycline (Dox, 50 mg/kg/day i.p. for 7 days), single dose of bicyclam (5 mg/kg i.p.), RA (15 mg/kg/day i.p. for 7 days), and their combination(s) on behavioral tests of nociception (Von Frey filaments; paw pressure test) on days 0, 1, 3, 5, and 7 of operation were studied. Serum concentrations of MCP-1 and SDF-1 were measured by ELISA. Histological examination of the sciatic nerve was investigated.CCI of sciatic nerve significantly induced mechanical allodynia and hyperalgesia and an increase of MCP-1 and SDF-1 serum levels. Dox-treated groups (Dox, Dox+bicyclam, Dox+RA, Dox+bicyclam+RA) and bicyclam-treated groups (bicyclam, Dox+bicyclam, bicyclam+RA, Dox+bicyclam+RA) attenuated CCI-induced behavioral and biochemical changes. RA inhibited CCI-induced mechanical hyperalgesia but produced a time-dependent reversal of allodynia. Histological findings showed degenerative changes of sciatic nerve after CCI that were partially recovered in Dox-treated groups.These findings demonstrate an association between serum MCP-1 and SDF-1 concentrations and behavioral manifestations of neuropathic pain. RA administration decreased neuropathic pain (antihyperalgesic effect) but did not cause any improvement in sciatic nerve tissues, either alone or in combination with chemokine antagonists. Thus, chemokines may serve as potential targets for drug development in neuropathic pain treatment.

scholarly journals Same virus, different course: The relationship between monocyte chemoattractant protein-1 and surfactant protein-A levels and clinical course and prognosis of COVID-19

2021 ◽  
Author(s):  
Ferhan Kerget ◽  
Buğra Kerget ◽  
Sibel İba Yılmaz ◽  
Ömer Karaşahin ◽  
Ahmet Kızıltunç ◽  
...  
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Clinical Course ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Control Group ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Objective: To date, over 7 million people have been infected in the COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 which emerged in Wuhan, China in December 2019. This study examined the relationships between serum monocyte chemoattractant protein-1 (MCP-1) and surfactant protein-A (SP-A) levels and the clinical course and prognosis of COVID-19. Method: The study included a total of 108 subjects. Those in the patient group (n=88) were diagnosed with COVID-19 using real-time PCR analysis of nasopharyngeal swab samples and treated in the Atatürk University Pulmonary Diseases and the City Hospital Infectious Diseases department between March 24 and April 15. The control group (n=20) included asymptomatic healthcare workers whose real-time PCR results during routine COVID-19 screening in our hospital were negative. Results: The COVID-19 patient group had significantly higher MCP-1 and SP-A levels compared to the control group (p=0.001, p=0.001). Patients who developed macrophage activation syndrome had significantly higher MCP-1 and SP-A levels than those who did not both at admission (p=0.001, p=0.001) and on day 5 of treatment (p=0.05, p=0.04). Similarly, MCP-1 and SP-A levels were significantly higher in patients who developed acute respiratory distress syndrome compared to those who did not at both time points (p=0.001 for all). Both parameters were significantly higher in nonsurviving COVID-19 patients compared to survivors (p=0.001 for both). Conclusion: MCP-1 and SP-A are on opposing sides of the inflammatory balance, and SP-A may be a pneumoprotein of importance in the presentation, course, prognosis, and possibly the treatment of COVID-19 in the future.

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