Resistance of naturally occurring regulatory T cells toward oxidative stress: possible link with intracellular catecholamine content and implications for cancer therapy

Blood ◽  
2009 ◽  
Vol 114 (2) ◽  
pp. 487-488 ◽  
Author(s):  
Marco Cosentino ◽  
Franca Marino ◽  
Sergio Lecchini
Keyword(s):  
Oxidative Stress ◽  
T Cells ◽  
Cancer Therapy ◽  
Regulatory T Cells ◽  
Catecholamine Content ◽  
Naturally Occurring

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death

Blood ◽  
2009 ◽  
Vol 113 (15) ◽  
pp. 3542-3545 ◽  
Author(s):  
Dimitrios Mougiakakos ◽  
C. Christian Johansson ◽  
Rolf Kiessling
Keyword(s):  
Oxidative Stress ◽  
T Cells ◽  
Cell Death ◽  
Regulatory T Cells ◽  
Suppressor Cells ◽  
Underlying Mechanism ◽  
Myeloid Derived Suppressor Cells ◽  
Inflammatory Conditions ◽  
Naturally Occurring ◽  
Solid Malignancies

Abstract Although the authors of several studies report elevated numbers of immunosuppressive regulatory T cells (Tregs) in hematologic and solid malignancies, the underlying mechanism is not fully clarified. Cancer is associated with oxidative stress mediated through reactive oxygen species produced by malignant cells, granulocytes, tumor-associated macrophages, and myeloid-derived suppressor cells. Oxidative stress is known to have detrimental effects on natural killer (NK) and T cells during chronic inflammatory conditions and cancer. Paradoxically, greater numbers of Tregs can be detected at tumor sites, indicating that Tregs can persist in this environment of increased oxidative stress. We demonstrate that Tregs, especially naive CD45RA+, exhibit reduced sensitivity to oxidative stress–induced cell death and maintain their suppressive function, a phenomenon that may be attributed to their observed high antioxidative capacity. This newly described characteristic could explain their enrichment in malignancies associated with increased levels of oxidative stress.

TCRαβ repertoire diversity of human naturally occurring CD4+CD25+ regulatory T cells

2005 ◽  
Vol 99 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Masumi Fujishima ◽  
Makoto Hirokawa ◽  
Naohito Fujishima ◽  
Ken-ichi Sawada
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Naturally Occurring ◽  
Repertoire Diversity

scholarly journals Response to Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4 + Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007

Diabetes ◽  
2008 ◽  
Vol 57 (3) ◽  
pp. e7-e8
Author(s):  
Michael Tritt ◽  
Evridiki Sgouroudis ◽  
Eva d’Hennezel ◽  
Alexandre Albanese ◽  
Ciriaco A. Piccirillo
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Autoimmune Diabetes ◽  
Naturally Occurring

Effect of immunosuppressants on the expansion and function of naturally occurring regulatory T cells

2007 ◽  
Vol 18 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Dong-Gyun Lim ◽  
In-Yi Joe ◽  
Youn-Hee Park ◽  
Sung-Ho Chang ◽  
Yu-Mee Wee ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Naturally Occurring ◽  
And Function

scholarly journals Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice

2011 ◽  
Vol 208 (12) ◽  
pp. 2489-2496 ◽  
Author(s):  
Uri Sela ◽  
Peter Olds ◽  
Andrew Park ◽  
Sarah J. Schlesinger ◽  
Ralph M. Steinman
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Graft Versus Host Disease ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Spleen Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Naturally Occurring

Foxp3+ regulatory T cells (T reg cells) effectively suppress immunity, but it is not determined if antigen-induced T reg cells (iT reg cells) are able to persist under conditions of inflammation and to stably express the transcription factor Foxp3. We used spleen cells to stimulate the mixed leukocyte reaction (MLR) in the presence of transforming growth factor β (TGF-β) and retinoic acid. We found that the CD11chigh dendritic cell fraction was the most potent at inducing high numbers of alloreactive Foxp3+ cells. The induced CD4+CD25+Foxp3+ cells appeared after extensive proliferation. When purified from the MLR, iT reg cells suppressed both primary and secondary MLR in vitro in an antigen-specific manner. After transfer into allogeneic mice, iT reg cells persisted for 6 mo and prevented graft versus host disease (GVHD) caused by co-transferred CD45RBhi T cells. Similar findings were made when iT reg cells were transferred after onset of GVHD. The CNS2 intronic sequence of the Foxp3 gene in the persisting iT reg cells was as demethylated as the corresponding sequence of naturally occurring T reg cells. These results indicate that induced Foxp3+ T reg cells, after proliferating and differentiating into antigen-specific suppressive T cells, can persist for long periods while suppressing a powerful inflammatory disease.

Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro

2012 ◽  
Vol 14 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Guang-ju Zhao ◽  
Zhong-qiu Lu ◽  
Lu-ming Tang ◽  
Zong-sheng Wu ◽  
Da-wei Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Naturally Occurring ◽  
Suppressive Capacity
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