Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population

Blood ◽  
2011 ◽  
Vol 118 (17) ◽  
pp. 4554-4560 ◽  
Author(s):  
Fabio Efficace ◽  
Michele Baccarani ◽  
Massimo Breccia ◽  
Giuliana Alimena ◽  
Gianantonio Rosti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Myeloid Leukemia ◽  
Term Therapy ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Long Term Therapy

Abstract The main objective of this study was to investigate whether patients with chronic myeloid leukemia (CML) in treatment with long-term therapy imatinib have a different health-related quality-of-life (HRQOL) profile compared with the general population. In total, 448 CML patients were enrolled, and the SF-36 Health Survey was used to compare generic HRQOL profiles. Symptoms were also assessed. HRQOL comparisons were adjusted for key possible confounders. The median age of patients was 57 years and the median time of imatinib treatment was 5 years (range 3-9 years). The largest HRQOL differences were found in younger patients. In particular, patients aged between 18 and 39 years had marked impairments in role limitations because of physical and emotional problems, respectively: −22.6 (P < .001), −22.3 (P < .001). Patients with CML age 60 or older had a HRQOL profile very similar to that reported by the general population. Women had a worse profile than men when each were compared with their peers in the general population. Fatigue was the most frequently reported symptom. The HRQOL of CML patients is comparable with that of population norms in many areas, however, younger and female patients seem to report the major limitations.

Health-Related Quality of Life and Long-Term Therapy with Pravastatin and Tocopherol (Vitamin E) in Older Adults

Drugs & Aging ◽  
2002 ◽  
Vol 19 (10) ◽  
pp. 793-805 ◽  
Author(s):  
Cynthia M. Carlsson ◽  
Kristi Papcke-Benson ◽  
Molly Carnes ◽  
Patrick E. McBride ◽  
James H. Stein
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Vitamin E ◽  
Term Therapy ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Long Term Therapy

scholarly journals Health-related quality of life of primary care patients with depressive disorders

2017 ◽  
Vol 41 (S1) ◽  
pp. S540-S540
Author(s):  
K. Riihimäki
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
General Population ◽  
Depressive Disorders ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Primary Care Patients

BackgroundDepressive disorders are known to impair health-related quality of life (HRQoL) both in the short and long term. However, the determinants of long-term HRQoL outcomes in primary care patients with depressive disorders remain unclear.MethodsIn a primary care cohort study of patients with depressive disorders, 82% of 137 patients were prospectively followed up for five years. Psychiatric disorders were diagnosed with SCID-I/P and SCID-II interviews; clinical, psychosocial and socio-economic factors were investigated by rating scales and questionnaires plus medical and psychiatric records. HRQoL was measured with the generic 15D instrument at baseline and five years, and compared with an age-standardized general population sample (n = 3707) at five years.ResultsDepression affected the 15D total score and almost all dimensions at both time points. At the end of follow-up, HRQoL of patients in major depressive episode (MDE) was particularly low, and the association between severity of depression (Beck Depression Inventory, BDI) and HRQoL was very strong (r = −0.804). The most significant predictors for change in HRQoL were changes in BDI and Beck Anxiety Inventory (BAI) scores. The mean 15D score of depressive primary care patients at five years was much worse than in the age-standardized general population, reaching normal range only among patients who were in clinical remission and had virtually no symptoms.ConclusionsAmong depressive primary care patients, presence of current depressive symptoms markedly reduces HRQoL, with symptoms of concurrent anxiety also having a marked impact. For HRQoL to normalize, current depressive and anxiety symptoms must be virtually absent.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

scholarly journals Health-related quality of life of primary care patients with depressive disorders

2016 ◽  
Vol 37 ◽  
pp. 28-34 ◽  
Author(s):  
K. Riihimäki ◽  
H. Sintonen ◽  
M. Vuorilehto ◽  
P. Jylhä ◽  
S. Saarni ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
General Population ◽  
Depressive Disorders ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Primary Care Patients

AbstractBackgroundDepressive disorders are known to impair health-related quality of life (HRQoL) both in the short and long term. However, the determinants of long-term HRQoL outcomes in primary care patients with depressive disorders remain unclear.MethodsIn a primary care cohort study of patients with depressive disorders, 82% of 137 patients were prospectively followed up for five years. Psychiatric disorders were diagnosed with SCID-I/P and SCID-II interviews; clinical, psychosocial and socio-economic factors were investigated by rating scales and questionnaires plus medical and psychiatric records. HRQoL was measured with the generic 15D instrument at baseline and five years, and compared with an age-standardized general population sample (n = 3707) at five years.ResultsDepression affected the 15D total score and almost all dimensions at both time points. At the end of follow-up, HRQoL of patients in major depressive episode (MDE) was particularly low, and the association between severity of depression (Beck Depression Inventory [BDI]) and HRQoL was very strong (r = −0.804). The most significant predictors for change in HRQoL were changes in BDI and Beck Anxiety Inventory (BAI) scores. The mean 15D score of depressive primary care patients at five years was much worse than in the age-standardized general population, reaching normal range only among patients who were in clinical remission and had virtually no symptoms.ConclusionsAmong depressive primary care patients, presence of current depressive symptoms markedly reduces HRQoL, with symptoms of concurrent anxiety also having a marked impact. For HRQoL to normalize, current depressive and anxiety symptoms must be virtually absent.

Health-Related Quality of Life 10 Years After Intracranial Aneurysm Rupture

Neurosurgery ◽  
2012 ◽  
Vol 72 (3) ◽  
pp. 397-406 ◽  
Author(s):  
Ann-Christin von Vogelsang ◽  
Kristina Burström ◽  
Yvonne Wengström ◽  
Mikael Svensson ◽  
Christina Forsberg
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Intracranial Aneurysm ◽  
Population Sample ◽  
Aneurysm Rupture ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract BACKGROUND: Experiencing an aneurysmal subarachnoid hemorrhage (SAH) could affect health-related quality of life (HRQoL) several years after the onset. Long-term studies are scarce, and there is a lack of knowledge of whether HRQoL is affected &gt; 5 years after the onset and, if so, in what dimensions. In the general population, HRQoL decreases with age and with the occurrence of a disease and differs between sexes. Factors that may influence HRQoL after aneurysmal SAH include neurological outcome, perceived recovery, aneurysm treatment, and family support. OBJECTIVE: To measure HRQoL and to explore factors affecting HRQoL 10 years after aneurysmal SAH. METHODS: A consecutive sample of all patients admitted for intracranial aneurysm rupture at a neurosurgical clinic in Stockholm (n = 217, 79.5% of eligible) were followed up from 2007 to 2008, approximately 10 years after aneurysm rupture. HRQoL was measured with EQ-5D, and the results were compared with a general population sample from the Stockholm Public Health Survey 2006 matched by age and sex. RESULTS: Compared with the general population, the aneurysm sample reported significantly more problems in 4 of 5 EQ-5D dimensions—mobility, self-care, usual activities, and anxiety/depression—and had significantly lower EQ-5Dindex and EQ visual analog scale values. Within the aneurysm sample, HRQoL was most affected in respondents with worse Glasgow Outcome Scale values at hospital discharge, respondents with comorbidities, and respondents with low perceived recovery. CONCLUSION: Aneurysmal SAH affects HRQoL to a large extent, even 10 years after the onset, indicating a need for long-term follow-up and support after the onset.

scholarly journals Long-Term Health-Related Quality of Life in German Patients with Juvenile Idiopathic Arthritis in Comparison to German General Population

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153267 ◽  
Author(s):  
Swaantje Barth ◽  
Johannes-Peter Haas ◽  
Jenny Schlichtiger ◽  
Johannes Molz ◽  
Betty Bisdorff ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Juvenile Idiopathic Arthritis ◽  
General Population ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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