Gadd45a regulates hematopoietic stem cell stress responses in mice

Blood ◽  
2014 ◽  
Vol 123 (6) ◽  
pp. 851-862 ◽  
Author(s):  
Yulin Chen ◽  
Xiaoming Ma ◽  
Meimei Zhang ◽  
Xiaomin Wang ◽  
Changxin Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Stress Responses ◽  
Cell Stress ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Dna Damage Responses

Key Points Loss of Gadd45a enhances HSC reconstitution on hematopoietic stress. Gadd45a regulates DNA damage responses in HSCs.

scholarly journals The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

Blood ◽  
2014 ◽  
Vol 124 (7) ◽  
pp. 1174-1182 ◽  
Author(s):  
Ying Taur ◽  
Robert R. Jenq ◽  
Miguel-Angel Perales ◽  
Eric R. Littmann ◽  
Sejal Morjaria ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Bacterial Diversity ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Intestinal Tract ◽  
Hematopoietic Stem ◽  
Key Points

Key Points Intestinal diversity is predictive of mortality in allo-HSCT.

scholarly journals Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

2019 ◽  
Vol 24 (4) ◽  
pp. 551-565.e8 ◽  
Author(s):  
Giulia Schiroli ◽  
Anastasia Conti ◽  
Samuele Ferrari ◽  
Lucrezia della Volpe ◽  
Aurelien Jacob ◽  
...  
Keyword(s):  
Dna Damage ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Dna Damage Response ◽  
Gene Editing ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Damage Response

scholarly journals Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency

Blood ◽  
2014 ◽  
Vol 124 (10) ◽  
pp. 1622-1625 ◽  
Author(s):  
Serine Avagyan ◽  
Michael Churchill ◽  
Kenta Yamamoto ◽  
Jennifer L. Crowe ◽  
Chen Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem Cell ◽  
Premature Aging ◽  
Hematopoietic Stem ◽  
Cell Dysfunction ◽  
Key Points ◽  
Deficient Mice

Key Points XLF-deficient mice recapitulate the lymphocytopenia of XLF-deficient patients. Premature aging of hematopoietic stem cells underlies the severe and progressive lymphocytopenia in XLF-deficient mice.

scholarly journals The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2812-2822 ◽  
Author(s):  
Tao Wang ◽  
Vijayalakshmi Nandakumar ◽  
Xiao-Xia Jiang ◽  
Lindsey Jones ◽  
An-Gang Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
And Function ◽  
Cell Maintenance

Key Points Mysm1 is required to maintain the quiescence and pool size of HSC, and its deletion severely impairs the survival and function of HSC. Mysm1 controls HSC homeostasis by regulating Gfi1 expression via modulating histone modifications and transcriptional factors recruitment.

scholarly journals Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Blood ◽  
2018 ◽  
Vol 132 (7) ◽  
pp. 735-749 ◽  
Author(s):  
Simranpreet Kaur ◽  
Liza J. Raggatt ◽  
Susan M. Millard ◽  
Andy C. Wu ◽  
Lena Batoon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Cell Engraftment ◽  
Key Points ◽  
Bone Marrow Engraftment

Key Points Recipient macrophages persist in hematopoietic tissues and self-repopulate via in situ proliferation after syngeneic transplantation. Targeted depletion of recipient CD169+ macrophages after transplant impaired long-term bone marrow engraftment of hematopoietic stem cells.

scholarly journals Alternative donors for allogeneic hematopoietic stem cell transplantation in poor-risk AML in CR1

2017 ◽  
Vol 1 (7) ◽  
pp. 477-485 ◽  
Author(s):  
Jurjen Versluis ◽  
Myriam Labopin ◽  
Annalisa Ruggeri ◽  
Gerard Socie ◽  
Depei Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Poor Risk ◽  
Key Points

Key Points The preferred donor for patients with poor-risk AML in CR1 proceeding to alloHSCT include MRD or 10/10 MUD. Alternative donors are 9/10 MUD, UCB grafts, and especially haplo, but sufficient numbers and follow-up to define a hierarchy are lacking.

scholarly journals Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

Blood ◽  
2013 ◽  
Vol 121 (25) ◽  
pp. 5015-5024 ◽  
Author(s):  
Sarah J. Stein ◽  
Albert S. Baldwin
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Lineage Commitment ◽  
Key Factors ◽  
Cell Homeostasis ◽  
Hematopoietic Stem ◽  
Expression Of Genes ◽  
Key Points ◽  
Genes Encoding

Key Points p65 is an important factor in hematopoiesis through the regulation of hematopoietic stem cell function and lineage commitment. p65 controls the expression of genes encoding key factors that promote hematopoietic stem cell homeostasis.

scholarly journals Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

Blood ◽  
2015 ◽  
Vol 125 (17) ◽  
pp. 2678-2688 ◽  
Author(s):  
Marisa Bowers ◽  
Bin Zhang ◽  
Yinwei Ho ◽  
Puneet Agarwal ◽  
Ching-Cheng Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem Cell ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Leukemia Development

Key Points Bone marrow OB ablation leads to reduced quiescence, long-term engraftment, and self-renewal capacity of hematopoietic stem cells. Significantly accelerated leukemia development and reduced survival are seen in transgenic BCR-ABL mice following OB ablation.

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