scholarly journals Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1

Blood ◽  
2015 ◽  
Vol 125 (14) ◽  
pp. 2228-2238 ◽  
Author(s):  
Jiun-Han Lin ◽  
Ju-Yin Lin ◽  
Ya-Ching Chou ◽  
Mei-Ru Chen ◽  
Te-Huei Yeh ◽  
...  
Keyword(s):  
Gene Expression ◽  
B Cell ◽  
Mhc Class Ii ◽  
Epstein Barr Virus ◽  
Class Ii ◽  
Barr Virus ◽  
Key Points ◽  
Cell Gene Expression ◽  
Epstein Barr ◽  
Cell Gene

Key PointsEBV LMP2A alters B-cell gene expression; E47 and PU.1 are repressed by LMP2A, resulting in downregulation of MHC class II expression.

MHC class II-restricted presentation of endogenously synthesized antigen: Epstein-Barr virus transformed B cell lines can present the viral glycoprotein gp340 by two distinct pathways

1993 ◽  
Vol 5 (5) ◽  
pp. 451-460 ◽  
Author(s):  
Steven P. Lee ◽  
Lesley E. Wallace ◽  
Michael Mackett ◽  
John R. Arrand ◽  
Peter F. Searle ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lines ◽  
Mhc Class Ii ◽  
Epstein Barr Virus ◽  
Class Ii ◽  
Viral Glycoprotein ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Modulating Gene Expression in Epstein‐Barr Virus (EBV)‐Positive B Cell Lines with CRISPRa and CRISPRi

2018 ◽  
Vol 121 (1) ◽  
Author(s):  
Liang Wei Wang ◽  
Stephen J. Trudeau ◽  
Chong Wang ◽  
Catherine Gerdt ◽  
Sizun Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
B Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency

2017 ◽  
Vol 1 (27) ◽  
pp. 2712-2723 ◽  
Author(s):  
Pradeep Bangalore-Prakash ◽  
Laura L. Stunz ◽  
Nurbek Mambetsariev ◽  
Amy L. Whillock ◽  
Bruce S. Hostager ◽  
...  
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Nuclear Signaling ◽  
B Lymphoma Cells ◽  
Key Points ◽  
Epstein Barr

Key Points Expression of the Epstein-Barr virus–encoded oncoprotein LMP1 leads to sequestration of TRAF3 in B-lymphoma cells. This sequestration inhibits TRAF3-negative regulation of prosurvival membrane, cytoplasmic, and nuclear signaling events in the B cell.

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