Impact of Venous Thromboembolism (VTE) Prophylaxis and Risk Stratification with the Caprini Model in Hospitalized Patients with Cancer

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 364-364
Author(s):  
Joshua M Ruch ◽  
Hsou M Hu ◽  
Vinita Bahl ◽  
Suman L. Sood
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Conflicts Of Interest ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
Medical Patients ◽  
Vte Prophylaxis ◽  
Patients With Cancer ◽  
Pharmacologic Prophylaxis ◽  
The Impact

Abstract Abstract 364 Introduction: VTE is a common complication in hospitalized medical patients and the role of pharmacologic anticoagulation prophylaxis is well-established. Patients with active malignancy are at higher risk for VTE during hospitalization. However, VTE prophylaxis is underutilized in these patients due to many real and perceived contraindications to prophylaxis. To aid clinicians in determining VTE risk and guide choice of prophylaxis, our institution adopted the Caprini risk assessment model (Ann Surg, 2010; 251[2]:344–50), based on clinical factors such as age, comorbidities, and recent surgery. Our primary objective was to assess adherence to recommended VTE prophylaxis in hospitalized medical patients with solid tumors, hematological malignancies, and bone marrow transplant (BMT) patients in comparison to general medical (GM) patients, and the impact of recommended prophylaxis use on VTE outcomes. Secondary objectives were to evaluate the distribution of Caprini risk scores and the utility of the Caprini risk assessment model for guiding prophylaxis in this population. Methods: Patients admitted to the hematology/oncology (HO; oncology, malignant hematology, and BMT) and GM inpatient services at the University of Michigan between July 1, 2009 to December 31, 2011 were included in the study. After IRB approval, patient information was extracted from the electronic medical record (EMR). A point-scoring method based on the Caprini risk assessment model was used to calculate VTE risk at admission. A score of 3–4 was high risk and ≥ 5 highest risk for VTE. Type of VTE prophylaxis and VTE rate were determined. Recommended prophylaxis was 5000 units TID SQ heparin, 30–40 mg SQ enoxaparin, or 2.5 mg SQ fondaparinux, ± sequential compression devices (SCDs). Pharmacological prophylaxis administration was verified in the EMR. VTE is defined as deep venous thrombosis (DVT) or pulmonary embolism (PE) occurring during hospitalization or within 90 days, confirmed by Doppler, CT or V/Q scan. Adherence was defined as the percentage of patients at high or highest risk for VTE with a length of stay ≥ 2 days who received guideline recommended prophylaxis within 2 days of admission. Patients with a contraindication to prophylaxis were excluded. A retrospective cohort study was performed. Chi-squared test was used to test differences in proportions and Cochran-Armitage test for trends. Results: 4300 patients were admitted to HO and 18,347 to GM services. Compared to GM patients (86.8%), the rate of adherence to recommended VTE prophylaxis was similar for oncology (87.6%), hematology (85.4%), and lower (45.6%) for BMT patients (p<0.0001). The overall VTE rate on HO services was 2.77%. Compared with 1.45% in GM, VTE rate was 3.02% in oncology (p=0.070), 2.01% in hematology (p=0.220), and 3.61% for BMT (p=0.001). Over half (51.3%) of VTE in HO patients occurred in patients who did not receive pharmacologic prophylaxis. In HO patients with a VTE, ordered prophylaxis included 16.0% combined pharmacological and SCD, 32.8% pharmacological alone, 32.8% SCD alone, and 18.5% none. Use of combined or pharmacologic prophylaxis alone was non-significantly increased in the non-VTE HO patients. By the Caprini risk assessment model, 33.3% of all patients on HO services were high and 62.2% highest risk, with less oncology (p=0.0001) and more BMT (p=0.0003) patients classified as high or highest risk. VTE rate in HO patients rose as Caprini risk score increased: score (n, % with VTE) 0–1 (23, 4.35%,); 2 (169, 0.59%); 3–4 (1434, 1.67%); 5–6 (1691, 2.90%); 7–8 (745, 3.76%); and 9 (238, 6.72%), p<0.0001 for trend. Conclusions: Adherence to recommended VTE prophylaxis was high in medical patients with cancer, resulting in low overall rates of VTE during and following discharge. The majority of patients with VTE did not receive recommended pharmacologic prophylaxis. Most VTE occurred in patients at highest risk (Caprini risk assessment score ≥ 5), with a trend to higher VTE rate as individual score increased. These data suggest that the individual Caprini score may provide more detailed VTE risk assessment and may help inform the need for prophylaxis despite perceived relative contraindications in this high risk cancer population. Further study is needed to understand the barriers to ordering VTE prophylaxis in this population and encourage increased prophylaxis use. Disclosures: No relevant conflicts of interest to declare.

A Validated Risk Model for Prediction of Early Readmission in Patients with Hepatic Encephalopathy

2018 ◽  
Vol 17 (5) ◽  
pp. 0-10
Author(s):  
Andrew J. Kruger ◽  
Fasika Aberra ◽  
Sylvester M. Black ◽  
Alice Hinton ◽  
James Hanje ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Hepatic Encephalopathy ◽  
High Risk ◽  
Risk Model ◽  
Cox Regression ◽  
Low Risk ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
Early Readmission ◽  
The Impact

Introduction and aim. Hepatic encephalopathy (HE) is a common complication in cirrhotics and is associated with an increased healthcare burden. Our aim was to study independent predictors of 30-day readmission and develop a readmission risk model in patients with HE. Secondary aims included studying readmission rates, cost, and the impact of readmission on mortality. Material and methods. We utilized the 2013 Nationwide Readmission Database (NRD) for hospitalized patients with HE. A risk assessment model based on index hospitalization variables for predicting 30-day readmission was developed using multivariate logistic regression and validated with the 2014 NRD. Patients were stratified into Low Risk and High Risk groups. Cox regression models were fit to identify predictors of calendar-year mortality. Results. Of 24,473 cirrhosis patients hospitalized with HE, 32.4% were readmitted within 30-days. Predictors of readmission included presence of ascites (OR: 1.19; 95% CI: 1.06-1.33), receiving paracentesis (OR: 1.43; 95% CI: 1.26-1.62) and acute kidney injury (OR: 1.11; 95% CI: 1.00-1.22). Our validated model stratified patients into Low Risk and High Risk of 30-day readmissions (29% and 40%, respectively). The cost of the first readmission was higher than index admission in the 30-day readmission cohort ($14,198 vs. $10,386; p-value < 0.001). Thirty-day readmission was the strongest predictor of calendar-year mortality (HR: 4.03; 95% CI: 3.49-4.65). Conclusions. Nearly one-third of patients with HE were readmitted within 30-days, and early readmission adversely impacted healthcare utilization and calendar-year mortality. With our proposed simple risk assessment model, patients at high risk for early readmissions can be identified to potentially avert poor outcomes.

External validation of the IMPROVE Bleeding Risk Assessment Model in medical patients

2016 ◽  
Vol 116 (09) ◽  
pp. 530-536 ◽  
Author(s):  
David J. Rosenberg ◽  
Anne Press ◽  
Joanna Fishbein ◽  
Martin Lesser ◽  
Lauren McCullagh ◽  
...  
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
High Risk Patient ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
Validation Sample ◽  
Medical Patients ◽  
Medically Ill ◽  
Major Bleed ◽  
Hospitalised Patients

SummaryThe IMPROVE Bleed Risk Assessment Model (RAM) remains the only bleed RAM in hospitalised medical patients using 11 clinical and laboratory factors. The aim of our study was to externally validate the IMPROVE Bleed RAM. A retrospective chart review was conducted between October 1, 2012 and July 31, 2014. We applied the point scoring system to compute risk scores for each patient in the validation sample. We then dichotomised the patients into those with a score <7 (low risk) vs ≥ 7 (high risk), as outlined in the original study, and compared the rates of any bleed, non-major bleed, and major bleed. Among the 12,082 subjects, there was an overall 2.6 % rate of any bleed within 14 days of admission. There was a 2.12 % rate of any bleed in those patients with a score of < 7 and a 4.68 % rate in those with a score ≥ 7 [Odds Ratio (OR) 2.3 (95 % CI=1.8–2.9), p<0.0001]. MB rates were 1.5 % in the patients with a score of < 7 and 3.2 % in the patients with a score of ≥ 7, [OR 2.2 (95 % CI=1.6–2.9), p<0.0001]. The ROC curve was 0.63 for the validation sample. This study represents the largest externally validated Bleed RAM in a hospitalised medically ill patient population. A cut-off point score of 7 or above was able to identify a high-risk patient group for MB and any bleed. The IMPROVE Bleed RAM has the potential to allow for more tailored approaches to thromboprophylaxis in medically ill hospitalised patients.Supplementary Material to this article is available online at www.thrombosis-online.com.

Preventing the Preventable—Improving thromboprophylaxis in oncology in-patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19648-19648
Author(s):  
R. Stevens ◽  
R. Jones ◽  
S. Oliveras ◽  
T. Abdullah ◽  
R. Leonard
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Initial Study ◽  
High Risk Group ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
Indwelling Catheters ◽  
Vte Prophylaxis ◽  
Oncology Ward ◽  
Very High

19648 Background: Cancer and its treatments are well recognised risk factors for venous thromboembolism (VTE). The risk of VTE complications in malignancy can be increased with surgery, chemotherapy (including adjuvant chemotherapy), hormone therapy and central indwelling catheters. Low molecular weight heparin (LMWH) has been shown to safely reduce the incidence of VTE in cancer patients however it is often not a standard of care within the oncology in-patient setting. Method: A retrospective study was carried out on admissions to the oncology ward for 1 month. Individual VTE risk was assessed using the modified THRiFT II risk assessment model and it was documented whether patients received any form of prophylaxis and the incidence of VTE. Following this study a VTE prophylaxis protocol was designed and implemented on the oncology ward and a repeat prospective study was carried out. Results: The initial study showed that in the very high risk group only 15% patients received thromboprophylaxis. 4 episodes of VTE occurred during the initial study period and these all occurred in patients stratified as very high risk. On the repeat study the results showed 50% of patients assessed as very high risk were now receiving prophylaxis. There was also a reduction in the rate of inappropriate prophylaxis from 17% to 0% in those assessed as lower risk. Conclusion: Primary prevention of VTE helps to reduce the morbidity and mortality associated with this common complication of malignancy. This study shows how a simple risk assessment model coupled with raised awareness of VTE risk improved the prophylaxis of those at highest risk and also reduced inappropriate usage in those at lesser risk. No significant financial relationships to disclose.

scholarly journals Risk Factors for Venous Thromboembolism in Hospitalized Patients in the Chinese Population

2018 ◽  
Vol 13 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Chunling Wang ◽  
Fuping Cui ◽  
Junqiu Li ◽  
Xiangzhi Yuan ◽  
Jia Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
Venous Thromboembolism ◽  
High Risk ◽  
Chinese Population ◽  
Blood Clot ◽  
Hospitalized Patients ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
Medical Patients

AbstractVenous thromboembolism (VTE) refers to the formation of a blood clot inside veins and has a high risk of inducing medical accidents. An effective risk assessment model will help screen high risk populations and prevent the occurrence of VTE. In this study, 287 VTE cases were collected and analyzed for risk factors in a Chinese population. The risks of VTE were evaluated using the Caprini and Padua models. Our results indicated that the Caprini model was more effective in evaluating VTE risk among hospitalized patients than the Padua model. As well, the Caprini model was more relevant in VTE risk assessment among surgery patients compared with internal medicine patients, while the Padua model showed no significant differences. In our studies, the most frequent risk factors included obesity, medical patients currently at bed rest, and severe lung disease. Our studies provide clinical support on selecting the suitable risk assessment model of VTE in the Chinese population.

scholarly journals An Alternative Risk Assessment Model of Urban Waterlogging: A Case Study of Ningbo City

2021 ◽  
Vol 13 (2) ◽  
pp. 826
Author(s):  
Meiling Zhou ◽  
Xiuli Feng ◽  
Kaikai Liu ◽  
Chi Zhang ◽  
Lijian Xie ◽  
...  
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Assessment Model ◽  
Risk Assessments ◽  
Risk Assessment Model ◽  
Risk Area ◽  
The North ◽  
Coastal Cities ◽  
Risk Areas ◽  
The City

Influenced by climate change, extreme weather events occur frequently, and bring huge impacts to urban areas, including urban waterlogging. Conducting risk assessments of urban waterlogging is a critical step to diagnose problems, improve infrastructure and achieve sustainable development facing extreme weathers. This study takes Ningbo, a typical coastal city in the Yangtze River Delta, as an example to conduct a risk assessment of urban waterlogging with high-resolution remote sensing images and high-precision digital elevation models to further analyze the spatial distribution characteristics of waterlogging risk. Results indicate that waterlogging risk in the city proper of Ningbo is mainly low risk, accounting for 36.9%. The higher-risk and medium-risk areas have the same proportions, accounting for 18.7%. They are followed by the lower-risk and high-risk areas, accounting for 15.5% and 9.6%, respectively. In terms of space, waterlogging risk in the city proper of Ningbo is high in the south and low in the north. The high-risk area is mainly located to the west of Jiangdong district and the middle of Haishu district. The low-risk area is mainly distributed in the north of Jiangbei district. These results are consistent with the historical situation of waterlogging in Ningbo, which prove the effectiveness of the risk assessment model and provide an important reference for the government to prevent and mitigate waterlogging. The optimized risk assessment model is also of importance for waterlogging risk assessments in coastal cities. Based on this model, the waterlogging risk of coastal cities can be quickly assessed, combining with local characteristics, which will help improve the city’s capability of responding to waterlogging disasters and reduce socio-economic loss.

Leveraging HCA Results in an Advanced Pipeline Risk Assessment Model

2014 ◽  
Author(s):  
Otto Huisman ◽  
Ricardo Almandoz ◽  
Thomas Schuster ◽  
Adriana Andrade Caballero ◽  
Leonardo Martinez Forero
Keyword(s):  
Risk Assessment ◽  
American Petroleum Institute ◽  
Assessment Model ◽  
Mitigation Measures ◽  
South American ◽  
Risk Assessment Model ◽  
Industry Standards ◽  
Management Approaches ◽  
American Society ◽  
The Impact

Pipeline risk analysis is a common step carried out by operators in their overall Pipeline Integrity Management Process. There is a growing realization among operators of the need to adopt more proactive risk management approaches. This has brought about increased demand for more quantitative models to support risk reduction decision-making. Consequences of failure are a key component of these models where enhanced quantitative approaches can be deployed. Impacts to the environment and upon populations are key issues which both operators and regulatory bodies seek to minimize. Pipeline risk models and High Consequence Area (HCA) analyses play an increasingly important role in this context by allowing operators to identify a range of potential scenarios and the relative impact to receptors based upon the best available data sources. This paper presents the process and results of an HCA analysis project carried out by ROSEN for a major South American state-owned pipeline operator (hereafter referred to as ‘the Client’). This analysis was implemented using automated GIS processing methods and includes HCA analyses for approximately 2354 km of pipeline. The analysis was based on industry standards for both liquid and gas pipelines (i.e. American Petroleum Institute (API) and American Society of mechanical Engineers (ASME)), but customized for the specific needs of the Client and the South American geographical context. A key use for the results of this analysis is to serve as input for the pipeline risk assessment model jointly developed by ROSEN Integrity Solutions, MACAW Engineering and the Client. The methodology for development of this model is briefly discussed, and operational uses of HCA results are illustrated. The benefits of this project include, but are not limited to, identifying areas that could be severely impacted should a pipeline failure occur, being able to assess the risk profile of credible threats in HCAs, but also being able to prioritize preventative and mitigation measures at HCAs to either reduce the likelihood of failure or the impact of failure upon various receptors.

Prevalence of Risk Factors for VTE In Hospitalized Medical and Surgical Patients. Data From the Comparison of Methods for Thromboembolic Risk Assessment with Clinical Perceptions and AwareneSS In Real Life Surgical and Medical Patients (COMPASS) Study

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3337-3337
Author(s):  
Grigoris T Gerotziafas ◽  
Miltos Chrysanthidis ◽  
Reda Isaad ◽  
Hela Baccouche ◽  
Chrysoula Papageorgiou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
Gastrointestinal Disease ◽  
Real Life ◽  
Bleeding Risk ◽  
Hospitalized Patients ◽  
Assessment Model ◽  
Surgical Patients ◽  
Medical Patients ◽  
The Impact

Abstract Abstract 3337 Introduction: Risk assessment models (RAM) are helpful tools for the screening VTE risk in hospitalized patients. Most of the available RAMs have been constructed on a disease-based or surgery-based approach and include some of the most relevant risk factors for VTE. There is limited information on the impact and importance of individual and comorbidity related risk factors for VTE present during hospitalization on the global VTE risk. Incorporation of the most frequent VTE risk and bleeding risk factors related to comorbidities might improve the ability of RAM to detect real-life patients at risk VTE and to evaluate drawbacks for the application of thromboprophylaxis. Aim of the study: The primary aim of the COMPASS programme was to evaluate the prevalence of the all known VTE and bleeding risk factors reported in the literature in real-life surgical and medical hospitalized patients. Methods: A prospective multicenter cross-sectional observational study was conducted in 6 hospitals in Greece and 1 in France. All inpatients aged >40 years hospitalised for medical diseases and inpatients aged >18 years admitted due to a surgical procedure and hospitalisation for a period exceeding three days were included. Patients and their treating physicians were interviewed with standardised questionnaire including all VTE and bleeding risk factors described in literature (130 items) on the third day of hospitalisation. Patients not giving informed consent, or receiving anticoagulant treatment for any reason or hospitalised in order to undergo diagnostic investigation without any further therapeutic intervention were excluded. Results: A total of 806 patients were enrolled in the study (414 medical and 392 surgical). Most frequent causes of hospitalisation in medical patients were infection (42%), ischemic stroke (14%), cancer (13%), gastrointestinal disease (9%), pulmonary disease (4%), renal disease (3%) and rheumatologic disease (1,4%). Surgical patients were hospitalised for vascular disease (22%) cancer (19,4%) gastrointestinal disease (12,5%), infection (8%), orthopaedic surgery and trauma (14%) or minor surgery (7%). Analysis of the frequency of risk factors for VTE showed that active cancer, recent hospitalisation, venous insufficiency and total bed rest without bathroom privileges were frequent in both groups. Medical patients had significantly more frequently than surgical patients several important predisposing risk factors for VTE. Moreover, medical patient had more frequently than surgical ones bleeding risk factors. The data for the most frequent risk factors are summarised in Table 1. Conclusion: COMPASS is the first registry that provides key data on the prevalence of all known VTE and bleeding risk factors in real life medical and surgical patients hospitalised in two countries of European Union. The analysis of the data shows that in addition to risk stemin from the disease or surgical act both medical and surgical patients share common VTE risk factors. The careful analysis of the most frequent and relevant VTE risk factors will allow the derivation of a practical VTE and bleeding risk assessment model taken into account these factors. Disclosures: Chrysanthidis: Sanofi-Aventis: Employment.

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