A Breakthrough in Understanding the Pathogenesis of Molar Hypomineralisation: The Mineralisation-Poisoning Model

Popularly known as “chalky teeth”, molar hypomineralisation (MH) affects over 1-in-5 children worldwide, triggering massive amounts of suffering from toothache and rapid decay. MH stems from childhood illness and so offers a medical-prevention avenue for improving oral and paediatric health. With a cross-sector translational research and education network (The D3 Group; thed3group.org) now highlighting this global health opportunity, aetiological understanding is urgently needed to enable better awareness, management and eventual prevention of MH. Causation and pathogenesis of “chalky enamel spots” (i.e., demarcated opacities, the defining pathology of MH) remain unclear despite 100 years of investigation. However, recent biochemical studies provided a pathomechanistic breakthrough by explaining several hallmarks of chalky opacities for the first time. This article outlines these findings in context of previous understanding and provides a working model for future investigations. The proposed pathomechanism, termed “mineralisation poisoning”, involves localised exposure of immature enamel to serum albumin. Albumin binds to enamel-mineral crystals and blocks their growth, leading to chalky opacities with distinct borders. Being centred on extracellular fluid rather than enamel-forming cells as held by dogma, this localising pathomechanism invokes a new type of connection with childhood illness. These advances open a novel direction for research into pathogenesis and causation of MH, and offer prospects for better clinical management. Future research will require wide-ranging inputs that ideally should be coordinated through a worldwide translational network. We hope this breakthrough will ultimately lead to medical prevention of MH, prompting global health benefits including major reductions in childhood tooth decay.

Russian Society for the Prevention of Noncommunicable Diseases (ROPNIZ). Alimentary-dependent risk factors for chronic non-communicable diseases and eating habits: dietary correction within the framework of preventive counseling. Methodological Guidelines

The methodological guidelines are developed as a practical document for medical specialists working in the field of preventive medicine, in order to expand and improve the provision of this type of medical service to the adult population. The methodological guidelines include an informational and informative part for medical specialists and a practical part for patients, presented in the format of memos, contain the main sections-healthy nutrition, correction of eating habits, issues of modifying the diet for the main alimentary-dependent risk factors for chronic non-communicable diseases, such as arterial hypertension, obesity, disorders of lipid, carbohydrate and purine metabolism, a decrease in bone mineral density. They are intended for medical specialists working in the field of prevention, for doctors and secondary medical personnel of offices and departments of medical prevention, public health and medical prevention centers, healthy lifestyle specialists, teachers of medical educational institutions, for specialists who develop and implement educational programs for patients, as well as for medical specialists of a therapeutic profile.

Prevention Practices and Legal Rules for Handling Pandemics in The Prophetic Sirah

This study focuses on highlighting the devotional and social preventive applications related to the epidemics, by shedding the lights on some stations from the biography and the sunnah of the Prophet peace be upon him, this will contribute to the prevention of epidemics, especially Coronavirus, by following the teaching of Sharia and the approach of the Prophet, peace be upon him, in dealing with such types of epidemics that appeared in his era. To achieve the goal of this study, we followed two approaches: inductive and analytical. We start by presenting the Hadiths that dealt with the topic of prevention in the Sunnah and biography, then we analyze the most prominent methods and applications followed by the Prophet in the prevention of epidemics. The research reached the following results, most of them, the precedence of Sunnah through what was illustrated in the Prophet’s biography in demonstrating the means of devotional and medical prevention against epidemics and their effectiveness in people’s lives. Finally, worshipping by obeying orders and avoiding prohibitions is a reason to prevent the epidemic.

Peter Chew "Logical Science" System For Epidemics(Covid-19)

Background: Lessons must be learned from the mistakes of the Covid pandemic. As we have seen, some countries are facing persistently high rates of covid-19 infection, but some countries such as China and South Korea can address the covid-19 problem when their country faces a surge in covid-19. This indicates that some countries facing persistently high infections may have used the wrong strategy, leaving them facing persistently high infections. The study will analyse what have been the main mistake since the Covid pandemic. Then create a system to solve the problem so that it can be used in future pandemic.Methods: Peter Chew’s "Logical Science" system focuses on logical review. The main purpose of the logical review part is to determine whether the guidelines are false. For non-medical treatment guidelines, if the logical review part determines that the guidelines are not false, real-world evidence is needed to determine whether the guidelines are correct. Similar to Mathematical Induction, The goal of the base case is to determine whether the statement (rule, formula, etc.) is false. If the sentence is not false, you need to continue to the second case, the inductive step determines whether the sentence (rule, formula, etc.) is true. Results: Using Peter Chew's "Logical Science" system, we can find wrong guidelines earlier. It can prevent continued practice of wrong guidelines, leading to persistently high infections. As we have seen, Director-general of the Chinese Canter for Disease Control and Prevention (CDC), George Gao said that in his view, a big mistake in the United States and Europe is that people do not wear masks. Therefore, early detection of wrong guidelines is important to reduce high infection rates. In fact, the important lesson we can learn from China’s response to the covid-19 surge is that China will not wait for study evidence to apply non-medical prevention, such as Wuhan compulsory wearing masks on January 22, 2020.Conclusions: Prevention is better than cure. Instead of creating new medical treatment or vaccine for viruses or mutant viruses, it is better to create a system to prevent the spread of pandemic viruses. As we have seen, China and South Korea managed to solve the covid-19 surge in their countries without using vaccines in 2020. Therefore, the epidemic prevention system must be able to detect any wrong guidelines faster to prevent the use of the wrong guidelines from causing widespread spread of the virus. For pandemics, waiting for research evidence to implement non-medical prevention strategies is a big mistake, because the prime time to reduce the spread of the virus has been missed. It takes time to generate research evidence, and follow-up peer review also takes time, so the process of peer review research evidence allows the virus to spread widely, and some mutations may occur, making virus prevention more difficult to deal with.

Peter Chew "Logical Science" System For Epidemics (Preprint)

BACKGROUND Lessons must be learned from the mistakes of the Covid pandemic. As we have seen, some countries are facing persistently high rates of covid-19 infection, but some countries such as China and South Korea can address the covid-19 problem when their country faces a surge in covid-19. This indicates that some countries facing persistently high infections may have used the wrong strategy, leaving them facing persistently high infections. The study will analyse what have been the main mistake since the Covid pandemic. Then create a system to solve the problem so that it can be used in future pandemic. METHODS Peter Chew’s "Logical Science" system focuses on logical review. The main purpose of the logical review part is to determine whether the guidelines are false. For non-medical treatment guidelines, if the logical review part determines that the guidelines are not false, real-world evidence is needed to determine whether the guidelines are correct. Similar to Mathematical Induction, The goal of the base case is to determine whether the statement (rule, formula, etc.) is false. If the sentence is not false, you need to continue to the second case, the inductive step determines whether the sentence (rule, formula, etc.) is true. RESULTS Using Peter Chew's "Logical Science" system, we can find wrong guidelines earlier. It can prevent continued practice of wrong guidelines, leading to persistently high infections. As we have seen, Director-general of the Chinese Canter for Disease Control and Prevention (CDC), George Gao said that in his view, a big mistake in the United States and Europe is that people do not wear masks. Therefore, early detection of wrong guidelines is important to reduce high infection rates. In fact, the important lesson we can learn from China’s response to the covid-19 surge is that China will not wait for study evidence to apply non-medical prevention, such as Wuhan compulsory wearing masks on January 22, 2020. CONCLUSIONS Prevention is better than cure. Instead of creating new medical treatment or vaccine for viruses or mutant viruses, it is better to create a system to prevent the spread of pandemic viruses. As we have seen, China and South Korea managed to solve the covid-19 surge in their countries without using vaccines in 2020. Therefore, the epidemic prevention system must be able to detect any wrong guidelines faster to prevent the use of the wrong guidelines from causing widespread spread of the virus. For pandemics, waiting for research evidence to implement non-medical prevention strategies is a big mistake, because the prime time to reduce the spread of the virus has been missed. It takes time to generate research evidence, and follow-up peer review also takes time, so the process of peer review research evidence allows the virus to spread widely, and some mutations may occur, making virus prevention more difficult to deal with.

The work of the medical prevention service of the Ulyanovsk Region during the spread of the novel coronavirus infection (COVID-19)

The purpose of the study was to monitor the activities of departments and offices of medical prevention of public health institutions during the period of restrictive measures related to the spread of the new coronavirus infection COVD19. Results: in health care institutions providing primary health care, the work of primary care was strengthened by specialists from departments, medical prevention offices: this is work with the district service, monitoring COVID-19 patients and contact, taking tests, forming mobile teams, visiting patients as part of the data brigades. Work was carried out at the entrance sanitary checkpoints, the population was informed through the Internet, print media (newspapers) on the prevention and non-proliferation of a new coronavirus infection. Conclusion: the monitoring made it possible to assess the actual activities of specialists in departments and offices of medical prevention of public health institutions during the period of restrictive measures. The temporary change in the functionality of the medical prevention service of the Ulyanovsk region made a significant contribution to the common cause of combating the COVID-19 pandemic.

COVID-19 pandemic: Analyzing of different pandemic control strategies using saturation models

Since December 2019, the world is confronted with the outbreak of the respiratory disease COVID-19. At the beginning of 2020, the COVID-19 epidemic evolved into a pandemic, which continues to this day. Within many countries, several control strategies or combinations of them, like restrictions (e.g. lockdown actions), medical care (e.g. development of vaccine or medicaments) and medical prevention (e.g. hygiene concept), were established with the goal to control the pandemic. Depending on the chosen control strategy, the COVID-19 spreading behavior slowed down or approximately stopped for a defined time range. This phenomenon is called saturation effect and can be described by saturation models: E.g. a fundamental approach is Verhulst (1838). The model parameter allows the interpretation of the spreading speed (growth) and the saturation effect in a sound way. This paper shows results of a research study of the COVID-19 spreading behavior and saturation effects depending on different pandemic control strategies in different countries and time phases based on Johns Hopkins University data base (2020). The study contains the analyzing of saturation effects related to short time periods, e.g. possible caused by lockdown strategies, geographical influences and medical prevention activities. The research study is focusing on reference countries like Germany, Japan, Denmark, Iceland, Ireland and Israel.