scholarly journals Lymphoid Nodules of Bone Marrow: Normal and Abnormal

Blood ◽  
1974 ◽  
Vol 43 (3) ◽  
pp. 389-400 ◽  
Author(s):  
Arkadi M. Rywlin ◽  
Rolando S. Ortega ◽  
Carlos J. Dominguez
Keyword(s):  
Bone Marrow ◽  
Malignant Lymphoma ◽  
Lymphoproliferative Disorder ◽  
Lymphoid Hyperplasia ◽  
Lymphocytic Leukemia ◽  
Reticulum Cell ◽  
Irregular Shapes ◽  
Nodular Lymphoid Hyperplasia ◽  
Well Differentiated ◽  
Lymphoid Nodules

Abstract A study of consecutive bone marrow aspirates from 365 patients without lymphoproliferative disorder, ten patients with chronic lymphocytic leukemia (CLL), and 25 patients with malignant lymphoma disclosed a clear separation of normal from abnormal lymphoid nodules (LN). Normal LN were found in 47% of patients and were classified into lymphoid follicles and lymphoid infiltrates. A new entity, nodular lymphoid hyperplasia (NLH), was diagnosed on ten bone marrows which contained a low-power field displaying four or more lymphoid nodules or showed a lymphoid nodule larger than 0.6 mm. The clinical significance of nodular lymphoid hyperplasia remains unknown; in certain cases it represents a precursor state of a mature lymphocytic lymphoproliferative disorder. Nodular aggregates in CLL are of the infiltrate type and exhibit a tendency to confluence. Eleven of the 25 patients with malignant lymphoma displayed lymphoreticular nodules which were cytologically similar to the original lymphoma and different from normal LN. Two patients, one with reticulum cell sarcoma and one with Hodgkin’s disease, showed NLH of the bone marrow. Bone marrow LN in patients with an established diagnosis of mature lymphocytic lymphoma have to be interpreted with the utmost caution. Confluence of LN, irregular shapes, and the presence of prolymphocytes and lymphoblasts speak for lymphomatous nodules. Additional clinicopathologic studies are necessary to sharpen the distinction between NLH and well-differentiated lymphoproliferative disorders.

Lymphoid Nodules and Nodular Lymphoid Hyperplasia in Bone Marrow Biopsies

1985 ◽  
Vol 74 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Roberto Navone ◽  
Mauro Valpreda ◽  
Achille Rich
Keyword(s):  
Bone Marrow ◽  
Lymphoid Hyperplasia ◽  
Bone Marrow Biopsies ◽  
Nodular Lymphoid Hyperplasia ◽  
Lymphoid Nodules

RARE CASE OF NODULAR LYMPHOID HYPERPLASIA OF LEFT LUNG IN THE PATIENT WITH PREVIOUS PULMONARY TUBERCULOSIS

2018 ◽  
Vol 40 (4) ◽  
pp. 332-335
Author(s):  
P V Kuzyk ◽  
M A Savchyna ◽  
S G Gychka
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lymphoproliferative Disorder ◽  
Clinical Laboratory ◽  
Left Lung ◽  
Lymphoid Hyperplasia ◽  
Morphological Examination ◽  
Nodular Lymphoid Hyperplasia ◽  
Lymph Nodes Dissection ◽  
The Right ◽  
Immunohistochemical Studies

Aim: To describe the case of rare benign lymphoproliferative disorder — pulmonary nodular lymphoid hyperplasia in the patient with previous pulmonary tuberculosis. Materials and Methods: In the case of pulmonary nodular lymphoid hyperplasia clinical, laboratory, instrumental and morphological examination was performed. Results: 44-year-old woman in 7 years after successfully treated infiltrative drug-susceptible tuberculosis of the right lung, was hospitalized with a suspected tumor of the left lung root. The patient underwent left-sided pneumonectomy with lymph nodes dissection. The results of histopathological and immunohistochemical studies evidenced on nodular lymphoid hyperplasia of the left lung. Conclusion: Pulmonary nodular lymphoid hyperplasia is a rare lymphoproliferative disorder of the lung with favorable prognosis. For the purpose of differential diagnosis, it is necessary to apply immunohistochemistry.

Malignant Lymphoma of the Small Bowel Associated with Diffuse Nodular Lymphoid Hyperplasia

1985 ◽  
Vol 313 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Claude Matuchansky ◽  
Guy Touchard ◽  
Marc Lemaire ◽  
Philippe Babin ◽  
François Demeocq ◽  
...  
Keyword(s):  
Small Bowel ◽  
Malignant Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Nodular Lymphoid Hyperplasia

Spontaneous Malignant Lymphoma in a New-World Primate

1974 ◽  
Vol 11 (1) ◽  
pp. 52-59 ◽  
Author(s):  
R. C. Page ◽  
L. Schectman ◽  
W. F. Ammons ◽  
L. Dillingham
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
New World ◽  
Reticulum Cell ◽  
Reticular Cell ◽  
Cell Type ◽  
Saguinus Oedipus ◽  
World Primate ◽  
Perivascular Infiltration

A spontaneous hematopoietic neoplasm in a cotton-top marmoset (Saguinus oedipus) was characterized by perivascular infiltration and invasion of the liver, kidneys, adrenals, spleen, lymph nodes, bone marrow, and lungs by a pleomorphic primitive reticular cell. A significant fraction of the circulating white cells was of the same cell type. The disease was diagnosed as lymphosarcoma of the reticulum-cell type with features similar to viral-induced malignancy previously described.

Concomitant Diagnosis of Chronic Myeloid Leukemia and B-Cell Chronic Lymphocytic Leukemia in a 57-Year-Old Female Patient, with Good Therapeutic Response Exclusively to Imatinib in Both Myeloid and Lymphoid Clones.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4583-4583
Author(s):  
Arthur Moellmann-Coelho ◽  
Luise Otero ◽  
Ricardo S. Bigni ◽  
Denise Azambuja ◽  
Claudio G. Stefanoff ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chronic Myeloid Leukemia ◽  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Therapeutic Response ◽  
Lymphocytic Leukemia ◽  
Well Differentiated ◽  
Cell Chronic Lymphocytic Leukemia

Abstract We describe the clinical, cytogenetic, hystopathologic, immunophenotypic and molecular findings of a rare case of Philadelphia positive chronic myeloid leukemia (Ph+ CML) and B-cell chronic lymphocytic leukemia (B-CLL) occurring simultaneously at diagnosis, in a 57-year-old female patient. In the present case, the patient showed at diagnosis leukocytosis (48.000/ul) with myelocytes and metamyelocytes along with well-differentiated neutrophils, but also with well differentiated lymphocytosis (28.992/ul) in peripheral blood (PB) and also in bone marrow (BM) aspirate cytology. FACS cytometry exhibited clearly two predominant separated cellular populations and the immunophenotype profile of the lymphoid component in BM and PB was CD5+, CD20+, CD23+, with light chain clonal restriction. The BM hystopathological analysis showed two distinct cellular populations, one lymphoid well differentiated CD5+/CD20+, and other myeloid, in several stages of differentiation. Cytogenetic analysis with unstimulated bone marrow culture confirmed the presence of Philadelphia chromosome but with additional translocation involving chromosomes 9, 10 and 22. Molecular studies showed the evidence of BCR-ABL positivity and the B-cell clone was documented by the presence of a clonal heavy chain immunoglobulin rearrangement. The patient was treated with imatinib mesylate 400mg/day, achieving complete cytogenetic response at the fourth month, and complete molecular response (nested PCR) of the BCR-ABL component at the sixth month of treatment. Besides, the absolute lymphocytosis was gradually reduced during the treatment exclusively with imatinib, achieving normal absolute values at the sixth month. This seldom described case of simultaneous occurrence of these two rare chronic hematological malignancies, brings interesting questions about the possible cellular origin and the correspondent mechanisms of clonal expansion. The therapeutic response of the B-cell lymphoid clone exhibited, brings also a possible relationship with the observation that the c-Abl could have enhanced expression in B-CLL cells, as described by Ke Lin et al, in which the c-Abl kinase activity could be inhibited by imatinib mesylate.

scholarly journals An Evaluation of Paraffin Sections of Aspirated Bone Marrow in Malignant Lymphomas

Blood ◽  
1955 ◽  
Vol 10 (8) ◽  
pp. 820-830 ◽  
Author(s):  
JACQUELINE D. PETTET ◽  
GERTRUDE L. PEASE ◽  
TALBERT COOPER
Keyword(s):  
Bone Marrow ◽  
Malignant Lymphoma ◽  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Reticulum Cell ◽  
Reticulum Cell Sarcoma ◽  
Paraffin Sections ◽  
Malignant Lymphomas ◽  
Cell Sarcoma

Abstract Examination of serial paraffin sections of bone-marrow aspirations has increased the known incidence of marrow involvement in malignant lymphomas. The results of this study can be seen in the table. In the 72 cases reviewed here, lesions compatible with malignant lymphoma were seen in paraffin sections in 22 cases. In 12 cases this was the only material available for diagnosis at the time. In an additional seven cases paraffin sections were considered suggestive of malignant lymphoma and in five of these a diagnosis could be made on the basis of examination of both smear and paraffin section. This procedure is particularly helpful in Hodgkin’s disease and reticulum cell sarcoma, where marrow smears are only rarely diagnostic. In general, the patients in whom lesions were found in the bone marrow tended to have more advanced disease than those in whom lesions were not found, and abnormalities in the peripheral blood were more common. This was especially true of patients with Hodgkin’s disease, less so in those with reticulum cell sarcoma. Patients with lymphosarcoma, lymphocytic type, did not show this difference, either in the extent of the disease or in findings on examination of peripheral blood. Diagnosis was most difficult in patients who had lymphocytic lymphosarcoma, since it was occasionally difficult to distinguish between the benign aggregations of lymphocytes which are not infrequently found in a large number of unrelated conditions and those aggregations which represented malignancy. Differentiation was made on the basis of number of aggregations, degree of circumscription, presence or absence of reaction centers and the cytologic appearance of the cells. Examination of the smears of the marrow is most helpful in these cases. Seven patients in this series (9.7 per cent) had granulomatous lesions in the marrow. In five of these the final diagnosis was Hodgkin’s disease, in one reticulum cell sarcoma and in one follicular lymphoma. Although these lesions were not specific, the incidence is high enough to make the finding of a granuloma of some significance in any patient suspected of having malignant lymphoma. The importance of thorough examination of any material obtained in an apparent dry tap and the value of repeated marrow-examinations is emphasized by three cases in this series. Since in many cases diagnostic lesions are found in only one portion of the material, examination of only one section of the paraffin sections of aspirated bone marrow is not sufficient for proper evaluation. This fact is emphasized by the greater incidence of positive findings in this report than in that of Cooper and Watkins. Studies of bone marrow should be particularly helpful in instances in which the diagnosis of malignant lymphoma is suggested by clinical features but cannot be proved by biopsy of peripheral nodes or other readily accessible tissue.

Sign in / Sign up

Export Citation Format

Share Document