scholarly journals Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes

Blood ◽  
1987 ◽  
Vol 70 (2) ◽  
pp. 444-447 ◽  
Author(s):  
ME Richardson ◽  
QG Chen ◽  
DA Filippa ◽  
K Offit ◽  
A Hampton ◽  
...  
Keyword(s):  
Cytogenetic Study ◽  
Chromosome Abnormalities ◽  
Chromosome 7 ◽  
Hodgkin's Lymphoma ◽  
Memorial Hospital ◽  
Low Grade ◽  
Lower Grade ◽  
Chromosome 6 ◽  
High Grade ◽  
Histological Evidence

We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying t(14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).

scholarly journals Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes

Blood ◽  
1987 ◽  
Vol 70 (2) ◽  
pp. 444-447 ◽  
Author(s):  
ME Richardson ◽  
QG Chen ◽  
DA Filippa ◽  
K Offit ◽  
A Hampton ◽  
...  
Keyword(s):  
Cytogenetic Study ◽  
Chromosome Abnormalities ◽  
Chromosome 7 ◽  
Hodgkin's Lymphoma ◽  
Memorial Hospital ◽  
Low Grade ◽  
Lower Grade ◽  
Chromosome 6 ◽  
High Grade ◽  
Histological Evidence

Abstract We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying t(14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).

Non-Hodgkin's lymphoma involving the tonsil: An immunohistochemical study

1991 ◽  
Vol 105 (6) ◽  
pp. 445-450 ◽  
Author(s):  
M. G. Watson ◽  
J. Crocker
Keyword(s):  
Clinical Outcome ◽  
Hodgkin’S Lymphoma ◽  
Immunohistochemical Study ◽  
Hodgkin's Lymphoma ◽  
Prognostic Indicators ◽  
Low Grade ◽  
High Grade ◽  
Non Hodgkin’S Lymphoma ◽  
Morphological Criteria ◽  
Non Hodgkin's Lymphoma

AbstractTwenty-one patients with non-Hodgkin's lymphoma involving the palatine tonsil were studied in an attempt to relate pathological data to clinical outcome. Eleven tumours were classified as low-grade and ten as high-grade on morphological criteria. The results of immunohistochemical investigations are presented; all tumours but one were of B-cell origin. None of the pathological factors studied were found to be useful prognostic indicators.

scholarly journals 6q deletions define distinct clinico-pathologic subsets of non- Hodgkin's lymphoma

Blood ◽  
1993 ◽  
Vol 82 (7) ◽  
pp. 2157-2162 ◽  
Author(s):  
K Offit ◽  
NZ Parsa ◽  
G Gaidano ◽  
DA Filippa ◽  
D Louie ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Recent Analysis ◽  
Low Grade ◽  
Chromosome 6 ◽  
Karyotypic Abnormality ◽  
Non Hodgkin’S Lymphoma ◽  
Lymphoid Neoplasms ◽  
Pathologic Features ◽  
Non Hodgkin's Lymphoma

Abstract Commonly observed in lymphoid neoplasms, deletions of 6q have been correlated with histologic and clinical subsets of non-Hodgkin's lymphoma (NHL). Our recent analysis of loss of heterozygosity of 6q loci in NHL showed two regions of minimal molecular deletion (RMD), an RMD1 at 6q25–27 and an RMD2 at 6q21–23. To establish correlations between these RMDs and regions of minimal cytogenetic deletions (RCDs) on 6q, and to define associations between RCDs and clinico-pathologic features, we have analyzed chromosome 6 abnormalities in 459 consecutively ascertained, karyotypically abnormal cases of NHL. Among these, 126 (27.5%) cases had structural abnormalities of chromosome 6, of which 94 were deletions. Analysis of these deletions identified three RCDs. An RCD1 encompassing 6q25–27 was seen in 45 intermediate- grade NHL. An RCD2 at 6q21 was observed in 11 high-grade NHL, 9 of which were of the immunoblastic subtype. An RCD3 at 6q23 was noted in 18 low-grade NHL lacking a t(14;18) translocation. Of these 18 cases, 12 were small lymphocytic NHL and, in 2 of these, del(6q) was the sole karyotypic abnormality. In 20 cases of low-grade NHL with t(14;18), the deletions spanned both RCD1 and RCD3. These data suggested the presence of at least 3 tumor suppressor genes on 6q within RCD1, RCD2, and RCD3; they also showed associations between RCDs in 6q and subsets of NHL, including a specific association between a group of well-differentiated lymphoid neoplasms and RCD3. The apparent heterogeneity of breakpoints when all NHLs are considered together explains the inability of previous studies to reliably establish correlations between recurring 6q deletions and histologic and clinical features of NHL.

Outcome Features Analysis in Intramedullary Tumors of the Cervicomedullary Junction: A Surgical Series

2021 ◽  
Author(s):  
Leonardo Tariciotti ◽  
Giacoma Maria Floriana Brunetto ◽  
Alessandro Landi ◽  
Fabrizio Gregori ◽  
Francesca Santoro ◽  
...  
Keyword(s):  
Low Grade ◽  
Lower Grade ◽  
Functional Evaluation ◽  
High Grade ◽  
Total Resection ◽  
Intramedullary Tumors ◽  
Macroscopic Appearance ◽  
Cervicomedullary Junction ◽  
The Impact

Abstract Object The aim of this study is to investigate the impact of surgery for different cervicomedullary lesions on symptomatic pattern expression and postoperative outcome. We focused on specific outcome features of the early and late postoperative assessments. The former relies on surgery-related transient and permanent morbidity and feasibility of radicality in eloquent areas, whereas the latter on long-term course in lower grade tumors and benign tumorlike lesions (cavernomas, etc.). Material and Methods We retrospectively analyzed 28 cases of intramedullary tumors of the cervicomedullary junction surgically treated at our institution between 1990 and 2018. All cases were stratified for gender, histology, macroscopic appearance, location, surgical approach, and presence of a plane of dissection (POD). Mean follow-up was 5.6 years and it was performed via periodic magnetic resonance imaging (MRI) and functional assessments (Karnofsky Performance Scale [KPS] and modified McCormick [MC] grading system). Results In all, 78.5% were low-grade tumors (or benign lesions) and 21.5% were high-grade tumors. Sixty-one percent underwent median suboccipital approach, 18% a posterolateral approach, and 21% a posterior cervical approach. Gross total resection was achieved in 54% of cases, near-total resection (>90%) in 14%, and subtotal resection (50–90%) in 32% of cases. Early postoperative morbidity was 25%, but late functional evaluation in 79% of the patients showed KPS > 70 and MC grade I; only 21% of cases showed KPS < 70 and MC grades II and III at late follow-up. Mean overall survival was 7 years in low-grade tumors or cavernomas and 11.7 months in high-grade tumors. Progression-free survival at the end of follow-up was 71% (evaluated mainly on low-grade tumors). Conclusions The surgical goal should be to achieve maximal cytoreduction and minimal postoperative neurologic damage. Functional outcome is influenced by the presence of a POD, radicality, histology, preoperative status, and employment of advanced neuroimaging planning and intraoperative monitoring.

scholarly journals Potential Diagnostic Value of the Differential Expression of Histone H3 Variants between Low- and High-Grade Gliomas

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5261
Author(s):  
Irati Hervás-Corpión ◽  
Andrea Gallardo-Orihuela ◽  
Inmaculada Catalina-Fernández ◽  
Irene Iglesias-Lozano ◽  
Olga Soto-Torres ◽  
...  
Keyword(s):  
Histone H3 ◽  
Diagnostic Value ◽  
Low Grade ◽  
Lower Grade ◽  
High Grade ◽  
Histone H3 Variant ◽  
Genes Encoding ◽  
High Grade Gliomas ◽  
Molecular Patterns ◽  
Canonical Histone

Glioblastoma (GB) is the most aggressive form of glioma and is characterized by poor prognosis and high recurrence despite intensive clinical interventions. To retrieve the key factors underlying the high malignancy of GB with potential diagnosis utility, we combined the analysis of The Cancer Gene Atlas and the REMBRANDT datasets plus a molecular examination of our own collection of surgical tumor resections. We determined a net reduction in the levels of the non-canonical histone H3 variant H3.3 in GB compared to lower-grade astrocytomas and oligodendrogliomas with a concomitant increase in the levels of the canonical histone H3 variants H3.1/H3.2. This increase can be potentially useful in the clinical diagnosis of high-grade gliomas, as evidenced by an immunohistochemistry screening of our cohort and can be at least partially explained by the induction of multiple histone genes encoding these canonical forms. Moreover, GBs showing low bulk levels of the H3.1/H3.2 proteins were more transcriptionally similar to low-grade gliomas than GBs showing high levels of H3.1/H3.2. In conclusion, this study identifies an imbalanced ratio between the H3 variants associated with glioma malignancy and molecular patterns relevant to the biology of gliomas, and proposes the examination of the H3.3 and H3.1/H3.2 levels to further refine diagnosis of low- and high-grade gliomas in future studies.

scholarly journals 6q deletions define distinct clinico-pathologic subsets of non- Hodgkin's lymphoma

Blood ◽  
1993 ◽  
Vol 82 (7) ◽  
pp. 2157-2162 ◽  
Author(s):  
K Offit ◽  
NZ Parsa ◽  
G Gaidano ◽  
DA Filippa ◽  
D Louie ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Recent Analysis ◽  
Low Grade ◽  
Chromosome 6 ◽  
Karyotypic Abnormality ◽  
Non Hodgkin’S Lymphoma ◽  
Lymphoid Neoplasms ◽  
Pathologic Features ◽  
Non Hodgkin's Lymphoma

Commonly observed in lymphoid neoplasms, deletions of 6q have been correlated with histologic and clinical subsets of non-Hodgkin's lymphoma (NHL). Our recent analysis of loss of heterozygosity of 6q loci in NHL showed two regions of minimal molecular deletion (RMD), an RMD1 at 6q25–27 and an RMD2 at 6q21–23. To establish correlations between these RMDs and regions of minimal cytogenetic deletions (RCDs) on 6q, and to define associations between RCDs and clinico-pathologic features, we have analyzed chromosome 6 abnormalities in 459 consecutively ascertained, karyotypically abnormal cases of NHL. Among these, 126 (27.5%) cases had structural abnormalities of chromosome 6, of which 94 were deletions. Analysis of these deletions identified three RCDs. An RCD1 encompassing 6q25–27 was seen in 45 intermediate- grade NHL. An RCD2 at 6q21 was observed in 11 high-grade NHL, 9 of which were of the immunoblastic subtype. An RCD3 at 6q23 was noted in 18 low-grade NHL lacking a t(14;18) translocation. Of these 18 cases, 12 were small lymphocytic NHL and, in 2 of these, del(6q) was the sole karyotypic abnormality. In 20 cases of low-grade NHL with t(14;18), the deletions spanned both RCD1 and RCD3. These data suggested the presence of at least 3 tumor suppressor genes on 6q within RCD1, RCD2, and RCD3; they also showed associations between RCDs in 6q and subsets of NHL, including a specific association between a group of well-differentiated lymphoid neoplasms and RCD3. The apparent heterogeneity of breakpoints when all NHLs are considered together explains the inability of previous studies to reliably establish correlations between recurring 6q deletions and histologic and clinical features of NHL.

scholarly journals Rethinking a Non-Predominant Pattern in Invasive Lung Adenocarcinoma: Prognostic Dissection Focusing on a High-Grade Pattern

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2785
Author(s):  
Yeonu Choi ◽  
Jonghoon Kim ◽  
Hyunjin Park ◽  
Hong Kwan Kim ◽  
Jhingook Kim ◽  
...  
Keyword(s):  
Preoperative Imaging ◽  
Dual Energy Ct ◽  
Low Grade ◽  
Lower Grade ◽  
High Grade ◽  
Intermediate Grade ◽  
Imaging Parameters ◽  
Ct Value ◽  
Histologic Pattern ◽  
Contrast Ct

Background: Prognostic considerations for non-predominant patterns are necessary because most lung adenocarcinomas (ADCs) have a mixed histologic pattern, and the spectrum of actual prognosis varies widely even among lung ADCs with the same most predominant pattern. We aimed to identify prognostic stratification by second most predominant pattern of lung ADC and to more accurately assess prognostic factors with CT imaging analysis, particularly enhancing non-predominant but high-grade pattern. Methods: In this prospective study, patients with early-stage lung ADC undergoing curative surgery underwent preoperative dual-energy CT (DECT) and positron emission tomography (PET)/CT. Histopathology of ADC, the most predominant and second most predominant histologic patterns, and preoperative imaging parameters were assessed and correlated with patient survival. Results: Among the 290 lung ADCs included in the study, 231 (79.7%) were mixed-pathologic pattern. When the most predominant histologic pattern was intermediate-grade, survival curves were significantly different among the three second most predominant subgroups (p = 0.004; low, lepidic; intermediate, acinar and papillary; high, micropapillary and solid). When the second most predominant pattern was high-grade, recurrence risk increased by 4.2-fold compared with the low-grade group (p = 0.005). To predict a non-predominant but high-grade pattern, the non-contrast CT value of tumor was meaningful with a lower HU value associated with the histologic combination of lower grade (low-grade as most predominant and intermediate-grade as second most predominant pattern, OR = 6.15, p = 0.005; intermediate-grade as most predominant and high-grade as second most predominant pattern, OR = 0.10, p = 0.033). SUVmax of the tumor was associated with the non-predominant but high-grade pattern, especially in the histologic combination of intermediate-high grade (OR = 1.14, p = 0.012). Conclusions: The second most predominant histologic pattern can stratify lung ADC patients according to prognosis. Thus, predicting the malignant potential and establishing treatment policies should not rely only on the most predominant pattern. Moreover, imaging parameters of non-contrast CT value and SUVmax could be useful in predicting a non-predominant but high-grade histologic pattern.

scholarly journals The Difference of Hypoxia Inducible Factor 2α mRNA Expression in High-Grade and Low-Grade Glioma Tissue

2019 ◽  
Vol 13 (2) ◽  
pp. 29
Author(s):  
Bagus Ramasha Amangku ◽  
Syaiful Ichwan ◽  
Septelia Inawati Wanandi ◽  
Novi Silvia Hardiany
Keyword(s):  
Hypoxia Inducible Factor ◽  
Hypoxic Condition ◽  
High Grade Glioma ◽  
Low Grade ◽  
Lower Grade ◽  
High Grade ◽  
Relative Expression ◽  
Method Of Calculation ◽  
The Difference ◽  
Metastasis Therapy

Background: HIF-2α is a transcription factor in hypoxic condition, and high expression levels of it correlate with the concepts of metastasis, therapy opposition and reduced quality of prognosis in various forms of cancerous growth. Due to the exceedingly infiltrative ability of brain glioma cells, gliomas cannot be completely deteriorated with surgery and the relapse rate is high. This study goal to identify the relative expression of HIF-2α gene in the direction of glioma malignancy and its classification. Methods: Specimens used in this research comprise of 20 glioma samples obtained from glioma patients in Cipto Mangunkusumo Hospital. Relative expression of HIF-2α was measured by utilizing quantitative Real Time-Polymerase Chain Reaction (RT-PCR). Cycle threshold (CT) values were achieved correlated with the amplified DNA, and then the relative expression was attained by using Livak method of calculation. Results: The results produced a greater average of relative expression of HIF-2α in the grade III and IV types (18.64; n=7) rather than in the lower grades (5.68; n=13). However, the data is statistically inconsequential. Conclusions: High-grade glioma tends to express HIF-2α mRNA higher compared to the lower grade. Therefore, it is possible to use HIF-2α as a prognostic marker for glioma- diagnosed patients, although additional experiments need to be performed to strengthen these facts.

Migmatite and melt segregation at Cooma, New South Wales

1992 ◽  
Vol 83 (1-2) ◽  
pp. 95-106 ◽  
Author(s):  
D. J. Ellis ◽  
M. Obata
Keyword(s):  
New South ◽  
New South Wales ◽  
Back Reaction ◽  
Low Grade ◽  
Lower Grade ◽  
High Grade ◽  
Melting Reaction ◽  
Similar Composition ◽  
South Wales ◽  
The Matrix

ABSTRACTThe Cooma Complex of southeastern New South Wales comprises an andalusite-bearing S-type granodiorite surrounded by migmatites and low-pressure metamorphosed pelitic and psammitic sediments. The migmatite formed by the melting reaction:Biotite + Andalusite + K-feldspar + Quartz + V = Cordierite + Liquidat about 350–400 MPa , 670-730°C.The melanosome consists of biotite + cordierite + andalusite + K-feldspar + plagioclase + quartz + ilmenite, whereas the leucosome consists of cordierite + K-feldspar + quartz with extremely rare biotite and plagioclase. In a closed system, freezing of the leucosome melt patches should have resulted in cordierite back-reaction with melt to produce biotite and andalusite. The virtually anhydrous mineralogy of the leucosome patches, lack of cordierite reaction and the absence of biotite selvedges at the leucosome-melanosome contacts, indicates that the melt did not completely solidify in situ. These observations can be explained by an initial peritectic melting reaction in the migmatite being arrested from back-reaction upon cooling because of the removal of hydrous melt, enabling leucosome cordierite to escape back-reaction. We propose that the melanosome is the residue of partial melting but that the leucosome patches do not represent frozen melt segregations but rather the liquidus minerals (cumulates) which precipitated from the melt.In the restite-rich granodiorite from the core of the Cooma Complex, cordierite of similar composition to that in the migmatite has reaction rims of biotite and andalusite and there are coexisting biotite and andalusite in the matrix. The granodiorite consisted of about 50 wt% melt together with resite biotite, quartz and plagioclase, which can possibly be identified in the surrounding migmatite. Previous work suggested that the Cooma Granodiorite can be derived from a mixture of the surrounding metasediments which are of similar composition in the high and low-grade areas surrounding the granodiorite. Re-examinatibn of those data shows that the high-grade metasediments are more An-rich than the low-grade rocks. The Cooma Granodiorite is very similar to the high-grade rocks in terms of Or-Ab-An ratio. This suggests derivation of the Cooma Granodiorite from the high-grade rocks and not from the relatively An-poor low-grade rocks which are typical of exposed sediments in the Lachlan Fold Belt. It is most likely that the granodiorite and envelope of high-grade rocks have been emplaced into the compositionally different lower grade rocks from slightly greater depths.

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