DDAVP and epinephrine-induced changes in the localization of von Willebrand factor antigen in endothelial cells of human oral mucosa
Keyword(s):
Abstract A peroxidase-labeled antibody technique revealed von Willebrand factor antigen (vWF:Ag) in rough endoplasmic reticulum (rER), the perinuclear region, and the cytoplasmic vesicles of capillary endothelial cells in oral mucosa. After administration of epinephrine or 1-deamino-8-D- arginine vasopressin (DDAVP), the localization of vWF:Ag was shown to have changed to the basement membrane and the surrounding interstitium. This change of vWF:Ag localization induced by epinephrine and DDAVP may play a role in the adhesion of platelets to subendothelium following endothelial injury during surgery and may be an unknown hemostatic effect of these drugs.
1991 ◽
Vol 15
(6)
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pp. 493-498
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2008 ◽
Vol 10
(6)
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pp. 372-379
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1996 ◽
Vol 55
(1)
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pp. 57-62
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1982 ◽
Vol 30
(11)
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pp. 1091-1096
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von Willebrand factor antigen levels are not predictive for the adult respiratory distress syndrome.
1995 ◽
Vol 151
(1)
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pp. 15-20
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1998 ◽
Vol 92
(3)
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pp. 395-400
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