Transforming growth factor beta downregulates interleukin-1 (IL-1)- induced IL-6 production by human monocytes
Keyword(s):
Tgf Beta
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Abstract We investigated the effects of transforming growth factor beta (TGF beta) on the induction by interleukin-1 beta (IL-1 beta) of IL-6 in human monocytes. We found that IL-1 beta induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant. TGF beta did not induce IL-6. In contrast, TGF beta added to the culture inhibited, in a dose-dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity. These results show that IL-1 beta is able to stimulate IL-6 production by monocytes, TGF beta, by inhibiting this effect, may play an important role in regulating the IL-1-mediated components of the inflammatory response.
1993 ◽
Vol 264
(1)
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pp. L36-L42
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1994 ◽
Vol 179
(3)
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pp. 1041-1045
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1990 ◽
Vol 110
(6)
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pp. 2209-2219
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1991 ◽
Vol 23
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pp. 48