scholarly journals Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

Blood ◽  
1994 ◽  
Vol 83 (5) ◽  
pp. 1408-1411 ◽  
Author(s):  
T Musso ◽  
GL Gusella ◽  
A Brooks ◽  
DL Longo ◽  
L Varesio
Keyword(s):  
Interferon Gamma ◽  
Mononuclear Cells ◽  
Inhibitory Effect ◽  
Interleukin 4 ◽  
Human Monocytes ◽  
Peripheral Blood Mononuclear ◽  
Ifn Gamma ◽  
Indoleamine 2,3 Dioxygenase ◽  
Blood Mononuclear Cells ◽  
Negative Signal

Abstract Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFN gamma in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.

scholarly journals Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

Blood ◽  
1994 ◽  
Vol 83 (5) ◽  
pp. 1408-1411
Author(s):  
T Musso ◽  
GL Gusella ◽  
A Brooks ◽  
DL Longo ◽  
L Varesio
Keyword(s):  
Interferon Gamma ◽  
Mononuclear Cells ◽  
Inhibitory Effect ◽  
Interleukin 4 ◽  
Human Monocytes ◽  
Peripheral Blood Mononuclear ◽  
Ifn Gamma ◽  
Indoleamine 2,3 Dioxygenase ◽  
Blood Mononuclear Cells ◽  
Negative Signal

Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFN gamma in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.

scholarly journals Inhibitory Effect of Glucocorticoid for Osteoblast Apoptosis Induced by Activated Peripheral Blood Mononuclear Cells

Endocrinology ◽  
1998 ◽  
Vol 139 (4) ◽  
pp. 2032-2040 ◽  
Author(s):  
Tomoki Nakashima ◽  
Hitoshi Sasaki ◽  
Masahiko Tsuboi ◽  
Atsushi Kawakami ◽  
Kaoru Fujiyama ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Inhibitory Effect ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Osteoblast Apoptosis
Sign in / Sign up

Export Citation Format

Share Document