Analysis of children’s diffuse parenchymal lung disease from the European Management Platform for Childhood Interstitial Lung Diseases: Frequency of disease categories and treatments used

Абстракт: Прогресивната системна склероза (Systemic sclerosis, SSc) представлява системно заболяване на съединителната тъкан, характеризиращо се с фиброзни промени, засягащи кожата и вътрешните органи, васкулопатия и имунна дисрегулация. Интерстициалните пневмонии представляват група дифузни паренхимни белодробни болести (diffuse parenchymal lung disease – ДПББ), или още наричани интерстициални белодробни болести, ИББ (interstitial lung diseases – ILD). ИББ е водещо усложнение на SSc и е водеща причина за смъртност при пациенти със SSc. Патогенезата на белодробното увреждане включва три основни процеса - персистираща увреда на еднотелните клетки, активация на имунната система и активация на фибробласти, водещо до акумулация на екстрацелуларен матрикс и тъканна увреда. Необходим е комплексен подход за правилно диганостициране и избор на терапия.

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Research highlights from the 2018 ERS International Congress: interstitial lung diseases

ERJ Open Research ◽

10.1183/23120541.00215-2018 ◽

2019 ◽

Vol 5 (1) ◽

pp. 00215-2018 ◽

Cited By ~ 2

Author(s):

Tiago M. Alfaro ◽

Catharina C. Moor ◽

Veronica Alfieri ◽

Florence Jeny ◽

Michael Kreuter ◽

...

Keyword(s):

Lung Disease ◽

Lung Diseases ◽

Interstitial Lung Diseases ◽

International Congress ◽

European Respiratory Society ◽

Diffuse Parenchymal Lung Disease ◽

Origin Group ◽

Parenchymal Lung Disease ◽

Selection Of ◽

Parenchymal Lung

This article reviews a selection of the scientific presentations on interstitial lung disease (ILD)/diffuse parenchymal lung disease (DPLD) that were made at the 2018 European Respiratory Society (ERS) International Congress in Paris. A number of advances in the epidemiology, pathogenesis, diagnosis and treatment of these disorders were presented and discussed by clinicians and researchers. The research topics span over all four groups of ERS Assembly 12: Interstitial Lung Diseases (Group 12.01: Idiopathic interstitial pneumonias; Group 12.02: ILD/DPLD of known origin; Group 12.03: Sarcoidosis and other granulomatous ILD/DPLD; Group 12.04: Rare ILD/DPLD).

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Diffuse parenchymal lung disease: An introduction

Oxford Textbook of Medicine ◽

10.1093/med/9780198746690.003.0414 ◽

2020 ◽

pp. 4166-4176

Author(s):

F. Teo ◽

A.U. Wells

Keyword(s):

Lung Disease ◽

Lung Diseases ◽

Pulmonary Function Tests ◽

Diagnostic Algorithm ◽

Clinical History ◽

Logical Sequence ◽

Diffuse Parenchymal Lung Disease ◽

Granulomatous Diseases ◽

Parenchymal Lung Disease ◽

Parenchymal Lung

The nomenclature of diffuse parenchymal lung disease (also known as interstitial lung disease) has caused a great deal of confusion, with use of complicated histopathological terms not always corresponding to clinico-radiological entities. Five major groupings are now recognized: idiopathic interstitial pneumonias; diseases associated with systemic conditions, including rheumatological disorders; diseases caused by environmental triggers or drugs; granulomatous diseases; and other diffuse lung diseases. Classification is based on recognition of clinical, radiological, and histopathological patterns, as opposed to the purely histopathological terminology. Diagnosis is complicated by the large number of disorders grouped within the diffuse parenchymal lung diseases. A systematic diagnostic algorithm, based upon careful clinical evaluation and a logical sequence of tests, is essential. Clinical history, clinical examination, chest radiography, pulmonary function tests, and selective blood tests should be followed by high-resolution CT, bronchoalveolar lavage (in some cases), and lung biopsy (in a few cases).

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Interstitial Fluid Lung Disease (IFLD) of the Interstitium Organ the Cause and Self-Care to a Self-Cure for Lung Disease

International Journal of Cancer Research & Therapy ◽

10.33140/ijcrt.05.01.01 ◽

2020 ◽

Vol 5 (1) ◽

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Lung Diseases ◽

Interstitial Fluid ◽

Self Care ◽

Air Sacs ◽

Diffuse Parenchymal Lung Disease ◽

Parenchymal Lung Disease ◽

Parenchymal Lung

Interstitial lung disease (IFLD), or diffuse parenchymal lung disease (DPLD), is a group of lung diseases affecting the Interstitium (the interstitial fluids or space around the alveoli (air sacs of the lungs) [1,2].

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