Cell type specific heat-shock-protein responses to bronchial thermoplasty in severe asthma treatment

2018 ◽  
Author(s):  
Lei Fang ◽  
Michael Tamm ◽  
Michael Roth ◽  
Daiana Stolz
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Specific Heat ◽  
Severe Asthma ◽  
Asthma Treatment ◽  
Cell Type ◽  
Bronchial Thermoplasty ◽  
Cell Type Specific

scholarly journals ATP-driven Non-equilibrium Activation of Kinase Clients by the Molecular Chaperone Hsp90

2020 ◽  
Author(s):  
Huafeng Xu
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Molecular Chaperone ◽  
Late Stage ◽  
Active Conformation ◽  
Cell Type ◽  
Protein Activation ◽  
Protein Substrates ◽  
Cell Type Specific ◽  
Kinetics Of

AbstractThe molecular chaperone 90-kDa heat-shock protein (Hsp90) assists the late-stage folding and activation of diverse types of protein substrates (called clients), including many kinases. Previous studies have established that the Hsp90 homodimer undergoes an ATP-driven cycle through open and closed conformations. Here I propose a model of client activation by Hsp90, which predicts that this cycle enables Hsp90 to use ATP energy to drive a client out of thermodynamic equilibrium toward its active conformation. My model assumes that an Hsp90-bound client can transition between a deactivating conformation and an activating conformation. It suggests that the cochaperone Cdc37 aids Hsp90 to activate kinase clients by differentiating between these two intermediate conformations. My model makes experimentally testable predictions, including how modulating the stepwise kinetics of the Hsp90 cycle—for example, by various cochaperones—affects the activation of different clients. My model may inform client-specific and cell-type-specific therapeutic intervention of Hsp90-mediated protein activation.

Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells

Cancer ◽  
2010 ◽  
Vol 116 (16) ◽  
pp. 3785-3796 ◽  
Author(s):  
Manoj Garg ◽  
Deepika Kanojia ◽  
Shikha Saini ◽  
Sushma Suri ◽  
Anju Gupta ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Germ Cell ◽  
Specific Heat ◽  
Cervical Carcinoma ◽  
Heat Shock Protein 70 ◽  
Migration And Invasion ◽  
Cervical Cells

Characterization of a 42°C-Specific Heat Shock Protein of Mammalian Cells1

1988 ◽  
Vol 103 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Ken-ichi Honda ◽  
Takumi Hatayama ◽  
Munehiko Yukioka
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Specific Heat

Common antigenicity of mouse 42°C-specific heat-shock protein with mouse hsp 105

1989 ◽  
Vol 160 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Ken-ichi Honda ◽  
Takumi Hatayama ◽  
Munehiko Yukioka
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Specific Heat

Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa

2001 ◽  
Vol 432 (4) ◽  
pp. 425-439 ◽  
Author(s):  
Virginian McMillan Carr ◽  
Bert Ph.M. Menco ◽  
Maya P. Yankova ◽  
Richard I. Morimoto ◽  
Albert I. Farbman
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Olfactory Mucosa ◽  
Cell Type ◽  
Shock Response ◽  
Cell Type Specific
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