Implementing and evaluating standardised tuberculosis incident management for non-household contacts in a large clinical network

The presented study summarizes the results of the implementation of liberal market reforms in Russia and reviews tools of the market economy that could solve the problem of distrust within Russian society.Aim. The study aims to define the underlying problems that stem from the peculiarities of the historical development of the Russian Federation and now hinder the advancement of our country to a new level of development, and to propose directions for solving these problems.Tasks. The authors summarize the socio-economic consequences of the implementation of liberal market reforms; define the problems of the implementation of a rent-based economy in modern Russia; prove that Russia cannot advance to a new level of development without solving the problem of social distrust; review the tools that could change the current situation of global social distrust (publicprivate partnership, proactive budgeting, clusters, territorial marketing, Far Eastern Hectare program, smart cities, incident management).Methods. This study uses general scientific methods of cognition to examine the results of the implementation of liberal market reforms, identify the problems of modern Russia, and determine the possible directions and tools of development.Results. Russia’s development is historically based on finding and living off the natural rent. This perspective significantly narrows the range of ideas about the potential development directions for the Russian Federation. The rent-based development options proposed today expose another common Russian trait — uncertainty, lack of risk appetite, pessimism, and fear of “things getting worse”. Implementation of democratic reforms in the context of rent-based economic institutions, lack of mutual trust within society, poor performance of courts — all this aggravates the current situation.Conclusions. Nowadays, Russia needs an economy that would create a demand for human capital and inclusive political institutions that would make people engaged in the life of the nation, allowing them to capitalize on their creativity without leaving their homeland.

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Immunobiological Markers in Prophylaxis Post-exposure with Single Dose of Rifampicin and BCG Vaccine in Contacts of Multibacillary Leprosy Cases: Study Protocol (Preprint)

10.2196/preprints.20968 ◽

2020 ◽

Author(s):

Camila Massae Sato ◽

Omar Ariel Espinosa Domínguez ◽

Gutembergue Santos de Sousa ◽

Fabiane Verônica da Silva ◽

Roberta Olmo Pinheiro ◽

...

Keyword(s):

Single Dose ◽

Bcg Vaccine ◽

Reference Laboratory ◽

Serological Response ◽

Bacillus Calmette Guerin ◽

Prophylactic Measure ◽

Mato Grosso ◽

Household Contacts ◽

Ifn Γ ◽

Multibacillary Leprosy

BACKGROUND Leprosy contacts are sensitive indicator of the magnitude of severity, and a high risk for infection and disease, especially if the individuals are exposed to the bacillus with multibacillary cases, which reinforces the need for chemoprophylactic measures, such as the use single-dose rifampicin (SDR) combined with BCG vaccine. OBJECTIVE Our study will analyze the serological response of anti-NDO-LID, HO-1/HMOX and serum IFN-γ concentration as a prophylactic measure after the use of single-dose rifampicin (SDR) combined with the Bacillus Calmette-Guérin vaccine (BCG) among multibacillary leprosy household contacts. METHODS Intervention study based on a prospective cohort of household contacts of new cases of multibacillary leprosy diagnosed and registered in the Information System on Diseases of Compulsory Declaration (SINAN – Sistema de Informação de Agravos de Notificação) and residents in the municipalities of Cuiabá and Cáceres, Mato Grosso, in the years 2019 and 2020. Contacts with no signs and symptoms compatible with the disease of the intervention group will receive single-dose rifampicin (SDR) combined with BCG vaccine and will be compared to the control group. The follow-up of the cohort will last 12 months. The analyses of the anti-NDO-LID, HO-1/HMOX and serum concentration of IFN-γ tests as immunological markers before, 6 and 12 months after the intervention will be conducted in a reference laboratory (FIOCRUZ). RESULTS The study is still recruiting participants and is expected to be completed in September 2020. CONCLUSIONS Our study seeks to analyze the response of anti-NDO-LID, HO-1/HMOX tests and serum IFN-γ concentration as a prophylactic measure after the use of single-dose rifampicin (SDR) combined with the Bacillus Calmette-Guérin vaccine (BCG) in home contacts of multibacillary leprosy cases. CLINICALTRIAL Brazilian Registry of Clinical Trials (ReBEC), RBR-6yg2z9. Retrospectively registered on 3 de Out. de 2019.

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The CDC Field Epidemiology Manual

10.1093/oso/9780190933692.001.0001 ◽

2019 ◽

Cited By ~ 3

Keyword(s):

Disease Outbreaks ◽

Incident Management ◽

The Public ◽

Field Epidemiology ◽

Field Investigations ◽

Toxic Agents ◽

Core Elements ◽

Multiple State ◽

Prompt Action ◽

Collection And Management

The CDC Field Epidemiology Manual is the definitive resource for the most up-to-date guidance for epidemiologists and other experts conducting field investigations to address acute public health concerns that require prompt action. This latest edition (an update of the 3rd edition of the popular book Field Epidemiology, edited by Dr. Michael Gregg) offers practical advice to guide investigators through the core elements of field investigations, beginning with initiating operations and ending with developing interventions and communicating findings to the public. The manual also provides special considerations to address challenges that often arise during field investigations, such as addressing legal issues, working with multiple state and federal agencies, navigating a multinational outbreak investigation, and working within an incident management structure. The manual includes updated information on using new tools for field investigations, such as the latest technologies for data collection and management and incorporating data from geographic information systems (GIS). Finally, the manual includes tips for investigations in a wide variety of settings, including healthcare and community congregate settings, and different types of outbreaks, including acute enteric disease outbreaks, those suspected to be related to intentional use of biologic and toxic agents, and outbreaks of suicide, violence, and other forms of injury. The manual is written primarily for epidemiologists who will be conducting field investigations in local, state, federal, or international settings. However, others who contribute to field investigations (e.g., laboratory scientists, lawyers, experts in public policy and communications) will also find the book to be an excellent source of information. The manual is written in an easily readable format, including boxes and bulleted points, to provide greater utility for investigators in the field.

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