Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population

The aim of the present work was to investigate the risk factors for gastric cancer- (GC-) associated thrombotic diseases in a Han Chinese population. A total of 333 patients diagnosed with GC, 68 with thrombotic diseases included in the case group and the remaining 265 in the control group, were enrolled. The relevant data for the participants, including general information (gender, age, smoking, and drinking), comorbidities (diabetes, hypertension, and anemia), tumor-related data (tumor site, histology, degree of differentiation, and clinical stage), and treatment-related data (surgery, chemotherapy, hormones, transfusion, and peripherally inserted central venous catheter (PICC)), were collected. Statistically significant factors derived from univariate analyses were then subjected to multivariate logistic regression analyses. The results demonstrate a statistically significant difference in age, diabetes, hypertension, histology, surgery, chemotherapy, and PICC ( P < 0.05 ), compared with control. Age, diabetes, surgery, and PICC serve as independent risk factors for GC-associated thrombotic diseases ( P < 0.05 ). The present work demonstrates that GC-associated thrombotic diseases are significantly associated with age, diabetes, surgery, and PICC, suggesting a potential target for early detection and preventive strategy for GC patients with thrombophilia.

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Polymorphisms of IL-23R predict survival of gastric cancer patients in a Chinese population

Cytokine ◽

10.1016/j.cyto.2019.01.014 ◽

2019 ◽

Vol 117 ◽

pp. 79-83 ◽

Cited By ~ 3

Author(s):

Bangshun He ◽

Bei Pan ◽

Yuqin Pan ◽

Xuhong Wang ◽

Lin Zhou ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Chinese Population ◽

Gastric Cancer Patients

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Correlation between SNPs in CDH1 and gastric cancer in Chinese population

Open Medicine ◽

10.1515/med-2015-0007 ◽

2015 ◽

Vol 10 (1) ◽

Author(s):

Yijin Lin ◽

Jintao Yuan ◽

Lihui Wang ◽

Lan Wang ◽

Yunjia Ma ◽

...

Keyword(s):

Gastric Cancer ◽

Single Nucleotide Polymorphisms ◽

Cancer Patients ◽

Chinese Population ◽

Sequencing Analysis ◽

Healthy Controls ◽

Nucleotide Polymorphisms ◽

Cdh1 Gene ◽

Single Nucleotide ◽

Gastric Cancer Patients

AbstractBackground. Many recent studies revealed that the single nucleotide polymorphisms have considerable effects on the susceptibility of cancer, such as prostate cancer, lung cancer and gastric cancer. The E-cadherin, a calcium-dependent transmembrane glycoprotein encoded by CDH1 gene, is critical for epithelial construction, intercellular adhesion and cell migration. Some associations have been reported between single nucleotide polymorphisms and gastric cancer in the Chinese population. Objective. To investigate whether the single nucleotide polymorphism in CDH1 gene is associated with the susceptibility of gastric cancer in the Chinese population. Material and methods. The genotypes of 5 known single nucleotide polymorphisms (rs33935154, rs121964871, rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls. High resolution melting curve detection and sequencing analysis were used in the present study. Results. There is a statistical significance in the rs121964871 C>G polymorphism between gastric cancer patients and healthy controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals (>50 years of age) carrying this risk factor may be more susceptible to gastric cancer. Conclusions. The results indicated that the rs121964871 C>G polymorphism is associated with the susceptibility of gastric cancer in the Chinese population, with some age and sex-dependent tendencies observed.

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