scholarly journals Immune response to live-attenuated Japanese encephalitis vaccine (JE-CV) neutralizes Japanese encephalitis virus isolates from South-East Asia and India

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Matthew Bonaparte ◽  
Bashir Dweik ◽  
Emmanuel Feroldi ◽  
Claude Meric ◽  
Alain Bouckenooghe ◽  
...  
Keyword(s):  
Immune Response ◽  
East Asia ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
South East Asia ◽  
Japanese Encephalitis Vaccine ◽  
Virus Isolates

scholarly journals Evidence of frequent introductions of Japanese encephalitis virus from south-east Asia and continental east Asia to Japan

2009 ◽  
Vol 90 (4) ◽  
pp. 827-832 ◽  
Author(s):  
Takeshi Nabeshima ◽  
Hyunh Thi Kim Loan ◽  
Shingo Inoue ◽  
Makoto Sumiyoshi ◽  
Yasuhiro Haruta ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
East Asia ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
East Asian ◽  
Asian Country ◽  
Encephalitis Virus ◽  
South East Asia ◽  
Asian Countries

The Japanese encephalitis virus (JEV) circulating in Japan consists of viruses with multiple phylogenetic origins. Phylogenetic analysis revealed that some JEV strains have recently migrated from south-east and continental east Asian countries. One phylogenetic subcluster of the JEV strains circulating in Japan was closely related to viruses isolated in Vietnam and China's inland region while other JEV subclusters were related to viruses isolated in Shanghai, China. One virus subcluster, however, was isolated solely in Japan and was not found in any other Asian country. Therefore, our data suggests that the JEVs that have remained or are circulating in Japan include a mixture of viruses that have previously migrated from south-east and continental east Asian countries.

scholarly journals Comparison of genomic and amino acid sequences of eight Japanese encephalitis virus isolates from bats

2013 ◽  
Vol 158 (12) ◽  
pp. 2543-2552 ◽  
Author(s):  
Shan Liu ◽  
Xing Li ◽  
Zhiyong Chen ◽  
Yixiong Chen ◽  
Qionghua Zhang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Amino Acid Sequences ◽  
Encephalitis Virus ◽  
Virus Isolates

A highly attenuated strain of Japanese encephalitis virus induces a protective immune response in mice

1996 ◽  
Vol 44 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Yi-Ling Lin ◽  
Ching-Len Liao ◽  
Chia-Tsui Yeh ◽  
Chin-Hsien Chang ◽  
Yue-Ling Huang ◽  
...  
Keyword(s):  
Immune Response ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Protective Immune Response

scholarly journals Japanese encephalitis virus: Uniqueness of immune response, vaccine development and future challenges

2016 ◽  
Vol 52 (02) ◽  
pp. 100-108
Author(s):  
Milind M. Gore
Keyword(s):  
Immune Response ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Rural Areas ◽  
Vaccine Development ◽  
Encephalitis Virus ◽  
Specific Cell ◽  
Cmv Promoter ◽  
Future Challenges ◽  
Chimeric Peptides

ABSTRACTJapanese encephalitis virus (JEV) is a major seasonal health problem in many rural areas in India and other parts of Asia. Transmission of virus is through mosquito vectors biting followed by peripheral multiplication site and exposed to host immune response before it succeeds in invasion of CNS. Thus protection from viral infection is a complex interplay of fight for superiority by virus and the host.Cell mediated immune response using transferred to non-immune 14 day mice and lethally challenged to study the protection. Results indicated that dominant immune response of T helper (Th) 2 type. Th and neutralizing antibody inducing epitopes on JEV were identified by combination of immunological and Bioinformatics platforms. Chimeric peptides incorporating both Th and B cell epitopes could protect mice. These epitopes were further incorporated in polytope DNA construct with four chimeric peptides and induce protective immunity in mice. In addition, overcome the anergy development by traditional DNA vaccine plasmid than of CMV promoter using antigen specific cell promoter rather was also studied.NIV carried out extensive studies on JE inactivated vaccines over the years. Studies were carried out mainly using CEC and Vero cells. Isolated of JEV from Kolar (821564) was extensively studied and thermostable mutant (821564 –XY) was selected and characterized genetically as well as antigenically. A commercial successfully produced purified, inactivated vaccine JENVAC is licensed is being successfully. Future challenges in terms of single dose vaccine with long lasting immunity, pig immunization vaccine as well newer related flavivirus are also important.

Sign in / Sign up

Export Citation Format

Share Document