Andressa Miranda Machado
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Isis Danyelle Dias Custódio
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Fernanda Silva Mazzutti
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Marceila de Andrade Fuzissaki
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Eduarda da Costa Marinho
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Abstract
Purpose This study aimed to evaluate the association between chemotherapy (CT) time, nutritional status and the effect of the interaction between these variables on the symptoms and domains of Health-Related Quality of Life (HRQoL). Despite the adverse effects CT, it’s common the gain weight and unfavorable changes in the body composition of women during and after the treatment. And an inadequate nutritional status can negatively impact the HRQoL and can influence the prognosis of breast cancer (BC).Methods This study was carried out with 55 women with BC over three periods of CT, T0, before the first cycle; T1, intermediate period; and T2, after the end of CT. HRQoLwas assessed using the 30-Item Quality of Life Questionnaire (QLQ-C30) and its BC module, the Quality of Life Questionnaire Breast Cancer − 23 (QLQ-Br23).Results Overweight, waist circumference (WC) indicative of increased risk and substantially increased risk of metabolic complications, waist-hip ratio (WHR) indicative of risk of developing chronic diseases, waist-to-height ratio (WHtR) indicative of excess abdominal fat and longer CT times (T1 and T2), each separately, as well as the interaction of these anthropometric variables with CT time, were associated with worse symptom and HRQoL domains scores.Conclusion The course of treatment and a worse nutritional status, have negative effects on HRQoL, and it is relevant to encourage women with BC undergoing CT to adopt a healthy diet and to practice physical activity in order to maintain an adequate nutritional status, that could contribute to a better HRQoL.