scholarly journals Systematic literature review assessing tobacco smoke exposure as a risk factor for serious respiratory syncytial virus disease among infants and young children

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Joseph R DiFranza ◽  
Anthony Masaquel ◽  
Amy M Barrett ◽  
Ann D Colosia ◽  
Parthiv J Mahadevia
2002 ◽  
Vol 196 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Fernando P. Polack ◽  
Michael N. Teng ◽  
Peter L.Collins ◽  
Gregory A. Prince ◽  
Marcus Exner ◽  
...  

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell–deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.


2012 ◽  
Vol 31 (6) ◽  
pp. 369-386 ◽  
Author(s):  
Marianne Bracht ◽  
Debbie Basevitz ◽  
Marilyn Cranis ◽  
Rose Paulley ◽  
Bosco Paes

Globally, respiratory syncytial virus (RSV) infection causes substantial morbidity in infants and young children, particularly those with specific risk factors (e.g., prematurity, chronic lung and congenital heart disease). Supportive measures are the mainstay of care for RSV-related disease. In the absence of medical treatments, RSV prophylaxis (RSVP) with palivizumab is recommended for high-risk patients to help reduce the risk of developing serious disease. Geographic distances, language and cultural barriers, and other factors can impede effective education of caregivers regarding the potential impact of RSV disease and benefits of RSVP compliance. We present our experiences developing successful Canadian RSVP programs, organized through a dedicated coordinator or small group of health care staff. These programs focus on identifying all infants and young children eligible for RSVP, effectively educating health care staff and family caregivers, developing educational tools that consider language and cultural factors, and interdisciplinary collaboration and networking throughout the health care system.


2012 ◽  
Vol 206 (2) ◽  
pp. 178-189 ◽  
Author(s):  
Jesse Papenburg ◽  
Marie-Ève Hamelin ◽  
Najwa Ouhoummane ◽  
Julie Carbonneau ◽  
Manale Ouakki ◽  
...  

2019 ◽  
Vol 38 (6) ◽  
pp. 589-594 ◽  
Author(s):  
Angela Gentile ◽  
María Florencia Lucion ◽  
María del Valle Juarez ◽  
María Soledad Areso ◽  
Julia Bakir ◽  
...  

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