The six minute walk test accurately estimates mean peak oxygen uptake

Abstract Background: The 6-minute walk test (6MWT) and incremental shuttle walk test (ISWT) are valid and reliable measures to assess exercise capacity of patients with chronic obstructive pulmonary disease (COPD). However, the comparison of correlation between peak oxygen uptake (peak VO2) and 6MWT or ISWT distance has not been investigated. We aimed to investigate the correlation between peak VO2 and 6MWT and ISWT distances in patients with COPD through a meta-analysis.Methods: We systematically searched MEDLINE, Scopus, Embase, and the Cochrane Library up to June 30, 2020 for studies comparing the correlation of peak VO2 with either 6MWT or ISWT in patients with COPD. Meta-analysis was performed with R software using a fixed-effect model. We compared the correlation coefficient and measured the heterogeneity using I2 statistics. Results: We identified 12 studies involving 746 patients. Meta-analysis showed a significant correlation between peak VO2 and 6MWT and ISWT distances (6MWT: r = 0.65, 95% CI: 0.61 to 0.70; ISWT: r = 0.81, 95% CI: 0.74 to 0.85; p < 0.0001). The heterogeneity was lower in ISWT than in 6MWT (6MWT: I2 = 56%, p = 0.02; ISWT: I2 = 0%, p = 0.71). Subgroup analysis showed a higher correlation coefficient in the low exercise capacity group than in the high exercise capacity group in both field tests. No risk of publication bias was identified.Conclusions: 6MWT and ISWT were significantly correlated with peak VO2. The findings suggest that ISWT had a stronger correlation with peak VO2 than did 6MWT in patients with COPD.Trial registration: CRD 42020200139 at crd.york.ac.uk/prospero/

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Accuracy of six minute walk test, stair test and spirometry using maximal oxygen uptake as gold standard

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502010000200013 ◽

2010 ◽

Vol 25 (2) ◽

pp. 194-200 ◽

Cited By ~ 25

Author(s):

Daniele Cristina Cataneo ◽

Shoiti Kobayasi ◽

Lídia Raquel de Carvalho ◽

Rafael Camargo Paccanaro ◽

Antonio José Maria Cataneo

Keyword(s):

Oxygen Uptake ◽

Maximal Oxygen Uptake ◽

Gold Standard ◽

Kappa Statistic ◽

Forced Expiratory Volume ◽

Stair Climbing ◽

Walk Test ◽

Exercise Tests ◽

Six Minute Walk Test ◽

Minute Walk

PURPOSE: To assess the accuracy of the variables stair climbing time (SCt), stair climbing power (SCP), six-minute walk test distance (6MWT), and forced expiratory volume in 1 second (FEV1) using maximal oxygen uptake on exercise (VO2max) as the gold standard. METHODS: Tests were performed in 51 patients. FEV1 was measured by spirometry and 6MWT was performed in a flat 120-m corridor. Stair climbing test was performed on a 6-flight stairway to obtain SCt and SCP. VO2max was measured by ergospirometry, using the Balke protocol. Pearson's linear correlation and p values were calculated between VO2max and the other variables tested. For accuracy calculations, variable cutoff points were obtained through receiver operating characteristic (ROC) curves, dividing individuals into normal or unhealthy. Kappa statistic was used to calculate concordance. RESULTS: Accuracy was: SCt - 86%, 6MWT - 80%, SCP - 71%, FEV1(L) - 67%, FEV1(%) - 63%. SCt and 6MWT showed 93.5% sensitivity when combined in parallel, and 96.4% specificity in series. CONCLUSION: SCt presented the best accuracy. SCt and 6MWT combined showed nearly 100% sensitivity or specificity. Thus, these simple exercise tests should be more routinely used, especially when an ergospirometer is not available to measure VO2max.

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