Vitamin A and risk of bladder cancer: a meta-analysis of epidemiological studies

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712–0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690–0.947], as well as in European population [RR=0.821, 95% CI=0.693–0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

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Vitamin E consumption and the risk of bladder cancer

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000553 ◽

2019 ◽

Vol 89 (3-4) ◽

pp. 168-175 ◽

Cited By ~ 2

Author(s):

Jian-Hai Lin ◽

Shao-Jun Chen ◽

Huan Liu ◽

Yang Yan ◽

Jun-Hua Zheng

Keyword(s):

Sensitivity Analysis ◽

Bladder Cancer ◽

Vitamin E ◽

Publication Bias ◽

Subgroup Analysis ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Epidemiological Studies ◽

Cochrane Library ◽

Response Analysis

Abstract. Background: Vitamin E has anti-cancer properties, which was demonstrated mainly due to its antioxidant effect. Several epidemiological studies have investigated the association between vitamin E consumption and the risk of bladder cancer. However, the results were inconsistent. The meta-analysis study aimed to evaluate the association of vitamin E consumption and the risk of bladder cancer. Methods: We conducted a systematic literature search in the electronic databases, which included MEDLINE, EMBASE and the Cochrane Library till 1 January 2016. The pooled relative risk ratios (RRs) with 95% confidence intervals (CIs) were calculated depending on the heterogeneity among studies. Subgroup analysis and sensitivity analysis were also performed. Publication bias was assessed using Begg’s test and Egger’s test. Results: A total of 11 prospective studies (3 randomized clinical trials and 8 cohort studies) including 575601 participants were identified to be eligible for our present meta-analysis. The pooled RRs with 95% CI for highest versus lowest vitamin E consumption was 0.89 (0.78–1.00). An inverse linear association between vitamin E consumption and bladder cancer risk was detected in the dose response analysis. The results were also stable in the subgroup analysis and sensitivity analysis. Meanwhile, no obvious publication bias was observed. Conclusions: Our study indicates that vitamin E consumption was inversely associated with the risk of bladder cancer.

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