The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712–0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690–0.947], as well as in European population [RR=0.821, 95% CI=0.693–0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

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The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20170155 ◽

2017 ◽

Vol 37 (3) ◽

Cited By ~ 4

Author(s):

Li Li ◽

Xuesong Gai

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Publication Bias ◽

Meta Analysis ◽

Case Control ◽

Significant Heterogeneity ◽

Case Control Studies ◽

Dietary Zinc ◽

Zinc Intake ◽

Pancreatic Cancer Risk

Previous reports have suggested a potential association on dietary zinc intake with the risk of pancreatic cancer. Since the associations between different studies were controversial, we therefore conducted a meta-analysis to reassess the relationship between dietary zinc intake and pancreatic cancer risk. A comprehensive search from the databases of PubMed, Embase, Web of Science, and Medline was performed until January 31, 2017. Relative risk (RR) with 95% confidence intervals (CI) derived by using random effect model was used. Sensitivity analysis and publication bias were conducted. Our meta-analysis was based on seven studies involving 1659 cases, including two prospective cohort studies and five case–control studies. The total RR of pancreatic cancer risk for the highest versus the lowest categories of dietary zinc intake was 0.798 (0.621–0.984), with its significant heterogeneity among studies (I2=58.2%, P=0.026). The average Newcastle–Ottawa scale (NOS) score was 7.29, suggesting a high quality. There was no publication bias in the meta-analysis about dietary zinc intake on the risk of pancreatic cancer. Subgroup analyses showed that dietary zinc intake could reduce the risk of pancreatic cancer in case–control studies and among American populations. In conclusion, we found that highest category of dietary zinc intake can significantly reduce the risk of pancreatic cancer, especially among American populations.

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Abstract 4297: Serum B6 vitamers (pyridoxal-5’-phosphate, pyridoxal, and 4’-pyridoxic acid) and pancreatic cancer risk: Two nested case-control studies in Asian populations

10.1158/1538-7445.am2016-4297 ◽

2016 ◽

Author(s):

Joyce Y. Huang ◽

Lesley M. Butler ◽

Øivind Midttun ◽

Per M. Ueland ◽

Woon-Puay Koh ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Case Control ◽

Case Control Studies ◽

Pancreatic Cancer Risk ◽

Asian Populations ◽

Nested Case Control

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Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies

Bioscience Reports ◽

10.1042/bsr20160345 ◽

2016 ◽

Vol 36 (5) ◽

Cited By ~ 6

Author(s):

Lei Wang ◽

Jianfeng Wang ◽

Xudong Liu ◽

Qian Liu ◽

Guozhuan Zhang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Publication Bias ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Epidemiological Studies ◽

Case Control Studies ◽

Selenium Intake ◽

Effect Model ◽

Summary Relative Risk

Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489–0.889, I2=47.6%]. The associations were significant both in case–control studies [RR=0.618, 95%CI=0.399–0.956, I2=59.1%] and Americas [RR=0.570, 95%CI=0.357–0.909, I2=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer.

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Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis

Public Health Nutrition ◽

10.1017/s1368980015001263 ◽

2015 ◽

Vol 19 (2) ◽

pp. 308-317 ◽

Cited By ~ 15

Author(s):

Manuela Chiavarini ◽

Liliana Minelli ◽

Roberto Fabiani

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Epidemiological Studies ◽

Pooled Analysis ◽

Case Control ◽

Dietary Factors ◽

Colorectal Cancer Risk ◽

Risk Estimate ◽

Case Control Studies

AbstractObjectiveColorectal cancer shows large incidence variations worldwide that have been attributed to different dietary factors. We conducted a meta-analysis on the relationship between garlic consumption and colorectal cancer risk.DesignWe systematically reviewed publications obtained by searching ISI Web of Knowledge, MEDLINE and EMBASE literature databases. We extracted the risk estimate of the highest and the lowest reported categories of intake from each study and conducted meta-analysis using a random-effects model.ResultsThe pooled analysis of all fourteen studies, seven cohort and seven case–control, indicated that garlic consumption was not associated with colorectal cancer risk (OR=0·93; 95 % CI 0·82, 1·06, P=0·281; I2=83·6 %, P≤0·001). Separate analyses on the basis of cancer sites and sex also revealed no statistically significant effects on cancer risk. However, when separately analysed on the basis of study type, we found that garlic was associated with an approximately 37 % reduction in colorectal cancer risk in the case–control studies (combined risk estimate=0·63, 95 % CI 0·48, 0·82, P=0·001; I2=75·6 %, P≤0·001).ConclusionsOur results suggest that consumption of garlic is not associated with a reduced colorectal cancer risk. Further investigations are necessary to clarify the discrepancy between results obtained from different types of epidemiological studies.

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Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis

Metabolism ◽

10.1016/j.metabol.2011.03.005 ◽

2011 ◽

Vol 60 (10) ◽

pp. 1372-1378 ◽

Cited By ~ 50

Author(s):

Valentina Rosato ◽

Alessandra Tavani ◽

Cristina Bosetti ◽

Claudio Pelucchi ◽

Renato Talamini ◽

...

Keyword(s):

Pancreatic Cancer ◽

Metabolic Syndrome ◽

Cancer Risk ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Pancreatic Cancer Risk ◽

Control Study

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Association between apurinic/apyrimidinic endonuclease 1 rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects

Bioscience Reports ◽

10.1042/bsr20190866 ◽

2019 ◽

Vol 39 (12) ◽

Cited By ~ 1

Author(s):

Guowen Ding ◽

Yu Chen ◽

Huiwen Pan ◽

Hao Qiu ◽

Weifeng Tang ◽

...

Keyword(s):

Cancer Risk ◽

Publication Bias ◽

Protective Factor ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Pooled Analysis ◽

Case Control ◽

Current Evidence ◽

Case Control Studies ◽

Risk Of Cancer

Abstract Background: Previous case–control studies have suggested that apurinic/apyrimidinic endonuclease 1 (APE1) rs1760944 T>G polymorphism may be associated with cancer risk. Here, we carried out an updated meta-analysis to focus on the correlation between APE1 rs1760944 T>G locus and the risk of cancer. Methods: We used the crude odds ratios (ORs) with their 95% confidence intervals (CIs) to evaluate the possible relationship between the APE1 rs1760944 T>G polymorphism and cancer risk. Heterogeneity, publication bias and sensitivity analysis were also harnessed to check the potential bias of the present study. Results: Twenty-three independent studies involving 10166 cancer cases and 11598 controls were eligible for this pooled analysis. We found that APE1 rs1760944 T>G polymorphism decreased the risk of cancer in four genetic models (G vs. T: OR, 0.87; 95% CI, 0.83–0.92; P<0.001; GG vs. TT: OR, 0.77; 95% CI, 0.69–0.86; P<0.001; GG/TG vs. TT: OR, 0.83; 95% CI, 0.77–0.89, P<0.001 and GG vs. TT/TG: OR, 0.85; 95% CI, 0.80–0.92, P<0.001). Results of subgroup analyses also demonstrated that this single-nucleotide polymorphism (SNP) modified the risk among lung cancer, breast cancer, osteosarcoma, and Asians. Evidence of publication bias was found in the present study. When we treated the publication bias with ‘trim-and-fill’ method, the adjusted ORs and CIs were not significantly changed. Conclusion: In conclusion, current evidence highlights that the APE1 rs1760944 T>G polymorphism is a protective factor for cancer susceptibility. In the future, case–control studies with detailed risk factors are needed to confirm or refute our findings.

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