The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy

Abstract Background This study examined whether mobile phone-based support improve the rates, duration of exclusive breastfeeding (EBF) as well as infant growth patterns in Nigeria. Methods A 6-month prospective randomized controlled trial with 75 participants assigned to receive ‘usual care’ or ‘mobile phone-based support in addition to usual care’ EBF rates and duration as well as anthropometric measurements of infants before and after intervention were compared using proportions and mean differences. Results Attrition rates of 10.7% and 14.7% were observed in the intervention and control groups, respectively. Treatment groups were identical in all baseline characteristics and participants in the intervention group showed a slower rate of decline in the practice of EBF. The mean difference of 0.6 months (95% confidence interval: −0.22, 1.42) in EBF duration between intervention and control groups was not statistically significant (t = 1.45; p = 0.149). Similarly, the difference in the EBF rates at the 6th month for the intervention (55.2%) and control (46.8%) groups was not statistically significant (χ2 = 0.623; p = 0.430). Although the intervention group had significantly higher mean weight (p = 0.030) and length (p = 0.044) at the 6th month, the difference in the gain in weight and length of these infants over the period was only significant for the weight (p = 0.044). Although the incidence of adverse clinical nutritional status was more in the control group, these differences were not statistically significant. Conclusion Mobile phone-based intervention has positive effects on the rate and duration of EBF as well as the growth of young infants. Sustaining this simple and cheap technology will improve infant wellbeing especially in resource-constrained settings.

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Mobile Phone Text Messaging for Tobacco Risk Communication Among Young Adult Community College Students: Protocol and Baseline Overview for a Randomized Controlled Trial

JMIR Research Protocols ◽

10.2196/10977 ◽

2018 ◽

Vol 7 (10) ◽

pp. e10977 ◽

Cited By ~ 2

Author(s):

Alexander V Prokhorov ◽

Georges Elias Khalil ◽

Karen Sue Calabro ◽

Tamara Costello Machado ◽

Sophia Russell ◽

...

Keyword(s):

College Students ◽

Community College ◽

Randomized Controlled Trial ◽

Young Adult ◽

Mobile Phone ◽

Community College Students ◽

Risk Communication ◽

Text Messaging ◽

Controlled Trial ◽

Randomized Controlled

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Mobile Phone Support for Diabetes Self-Care Among Diverse Adults: Protocol for a Three-Arm Randomized Controlled Trial (Preprint)

10.2196/preprints.9443 ◽

2017 ◽

Author(s):

Lyndsay A Nelson ◽

Kenneth A Wallston ◽

Sunil Kripalani ◽

Robert A Greevy Jr ◽

Tom A Elasy ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Mobile Phone ◽

Text Messaging ◽

Controlled Trial ◽

Self Care ◽

Exercise Adherence ◽

Text Messages ◽

Patient Specific ◽

Randomized Controlled

BACKGROUND Nonadherence to self-care is common among patients with type 2 diabetes (T2D) and often leads to severe complications. Moreover, patients with T2D who have low socioeconomic status and are racial/ethnic minorities disproportionately experience barriers to adherence and poor outcomes. Basic phone technology (text messages and phone calls) provides a practical medium for delivering content to address patients’ barriers to adherence; however, trials are needed to explore long-term and sustainable effects of mobile phone interventions among diverse patients. OBJECTIVE The aim of this study is to evaluate the effects of mobile phone–based diabetes support interventions on self-care and hemoglobin A1c (HbA1c) among adults with T2D using a 3-arm, 15-month randomized controlled trial with a Type 1 hybrid effectiveness-implementation approach. The intervention arms are (1) Rapid Encouragement/Education And Communications for Health (REACH) and (2) REACH + Family-focused Add-on for Motivating Self-care (FAMS). METHODS We recruited primary care patients with T2D (N=512) from Federally Qualified Health Centers and an academic medical center, prioritizing recruitment of publicly insured and minority patients from the latter. Eligible patients were prescribed daily diabetes medication and owned a cell phone with text messaging capability. We excluded patients whose most recent HbA1c result within 12 months was <6.8% to support detection of intervention effects on HbA1c. Participants were randomly assigned to REACH only, REACH + FAMS, or the control condition. REACH provides text messages tailored to address patient-specific barriers to medication adherence based on the Information-Motivation-Behavioral skills model, whereas FAMS provides monthly phone coaching with related text message content focused on family and friend barriers to diet and exercise adherence. We collect HbA1c and self-reported survey data at baseline and at 3, 6, and 12 months, and again at 15 months to assess sustained changes. We will use generalized estimating equation models to test the effects of REACH (either intervention arm) on HbA1c relative to the control group, the potential additive effects of FAMS, and effects of either intervention on adherence to self-care behaviors and diabetes self-efficacy. RESULTS The trial is ongoing; recruitment closed December 2017. We plan to perform analyses on 6-month outcomes for FAMS in July 2018, and project to have 15-month data for REACH analyses in April 2019. CONCLUSIONS Our study will be one of the first to evaluate a long-term, theory-based text messaging intervention to promote self-care adherence among racially/ethnically and socioeconomically diverse adults with T2D. Moreover, our study will assess the feasibility of a family-focused intervention delivered via mobile phones and compare the effects of text messaging alone versus text messaging plus phone coaching. Findings will advance our understanding of how interventions delivered by phone can benefit diverse patients with chronic conditions. CLINICALTRIAL ClinicalTrials.gov NCT02409329; https://clinicaltrials.gov/ct2/show/NCT02409329 (Archived by WebCite at http://www.webcitation.org/6yHkg9SSl); NCT02481596; https://clinicaltrials.gov/ct2/show/NCT02481596 (Archived by WebCite at http://www.webcitation.org/6yHkj9XD4)

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Promoting adherence to treatment for latent TB infection through mobile phone text messaging: study protocol for a pilot randomized controlled trial

Pilot and Feasibility Studies ◽

10.1186/s40814-017-0128-9 ◽

2017 ◽

Vol 3 (1) ◽

Cited By ~ 10

Author(s):

Eyal Oren ◽

Melanie L. Bell ◽

Francisco Garcia ◽

Carlos Perez-Velez ◽

Lynn B. Gerald

Keyword(s):

Randomized Controlled Trial ◽

Mobile Phone ◽

Study Protocol ◽

Text Messaging ◽

Controlled Trial ◽

Adherence To Treatment ◽

Randomized Controlled ◽

Latent Tb ◽

Latent Tb Infection ◽

Pilot Randomized Controlled Trial

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Text4Heart II; Improving medication adherence in people with heart disease: A randomized controlled trial (Preprint)

10.2196/preprints.24952 ◽

2020 ◽

Author(s):

Ralph Maddison ◽

Yannan Jiang ◽

Ralph Stewart ◽

Tony Scott ◽

Andrew Kerr ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Heart Disease ◽

New Zealand ◽

Medication Adherence ◽

Usual Care ◽

Text Messaging ◽

Controlled Trial ◽

Health Technologies ◽

Coronary Syndrome ◽

Randomized Controlled

BACKGROUND Mobile health technologies offer potential to improve reach and delivery of interventions to promote long-term secondary prevention of coronary heart disease (CHD). OBJECTIVE To determine the effectiveness of a text-messaging intervention (Text4HeartII) to improve adherence to medication and lifestyle change over and above usual care in people with CHD. METHODS A two-arm, parallel, randomized controlled trial conducted in New Zealand. Participants with a recent acute coronary syndrome were randomised to receive usual cardiac services alone (control n=153) or a 24-week text message programme to support self-management plus usual cardiac services (n=153). The primary outcome was adherence with medication at 24-weeks, defined as medication possession ratio (MPR) of 80% or more for aspirin, statin and anti-hypertensive therapy. Secondary outcomes included MPR at 52-weeks, self-reported medication adherence, and adherence with healthy lifestyle behaviours at 24- and 52-weeks. RESULTS National hospitalization and pharmacy dispensing records were available for all participants; 282 (92%) completed 24-weeks questionnaire and 291 (95%) completed 52-weeks questionnaire. Adherence with 3 medication classes was greater in the control compared to the intervention group, respectively both at 24-weeks (105(69%) versus 87(57%) OR 0.60, 95%CI 0.38 to 0.96, p=0.03), and 52 weeks (104(68%) vs 83(53%) OR 0.56, 95%CI 0.35 to 0.89, p=0.01). Self-reported medication adherence score showed the same trend at 52 weeks (mean difference 0.3, 95%CI 0.01 to 0.59, p=0.04). Self-reported adherence with health related behaviours were similar between groups. CONCLUSIONS Text4HeartII did not improve dispensed medication, or adherence to a favorable lifestyle over and above usual care. This finding contrasts with previous studies, and highlights that the benefits of text interventions may depend on the context in which they are used. CLINICALTRIAL Australian New Zealand Clinical Trials Registry, ID: ACTRN12616000422426

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