scholarly journals Stem cell: from basic theoretical assumptions and mathematical concepts to the computational models

2011 ◽  
Vol 5 (S8) ◽  
Author(s):  
Katya Simeonova ◽  
Ganka Milanova
2018 ◽  
Vol 123 (Suppl_1) ◽  
Author(s):  
Farnaz Shoja-Taheri ◽  
Alex George ◽  
Manu O Platt ◽  
Michael E Davis

2018 ◽  
Vol 22 (04) ◽  
pp. 687-688 ◽  
Author(s):  
IVA IVANOVA ◽  
DANIEL KLEINMAN

A major benefit of computational models is their ability to demonstrate which theoretical assumptions are truly necessary to explain a pattern of data. Dijkstra, Wahl, Buytenhuijs, van Halem, Al-jibouri, de Korte, and Rekké (in press) have impressively shown with Multilink that it is possible to account for a range of findings from bilingual lexical decision, word naming, and forward and backward translation tasks with an integrated lexicon, without lateral connections between translation equivalents, and without inhibition. In this commentary, we consider the applicability of the current model to other multilingual language production tasks, and note where the model's assumptions might need revision as its scope is expanded.


2015 ◽  
Vol 137 (7) ◽  
Author(s):  
Ralf Frotscher ◽  
Jan-Peter Koch ◽  
Manfred Staat

We compare experimental and computational results for the actions of the cardioactive drugs Lidocaine, Verapamil, Veratridine, and Bay K 8644 on a tissue monolayer consisting of mainly fibroblasts and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSc-CM). The choice of the computational models is justified and literature data is collected to model drug action as accurately as possible. The focus of this work is to evaluate the validity and capability of existing models for native human cells with respect to the simulation of pharmaceutical treatment of monolayers and hiPSc-CM. From the comparison of experimental and computational results, we derive suggestions for model improvements which are intended to computationally support the interpretation of experimental results obtained for hiPSc-CM.


Author(s):  
Cintia Terezinha Barbosa Peixoto ◽  
Isabel Cristina Machado De Lara

ResumoEste artigo apresenta, em uma abordagem qualitativa, um estudo de caso no qual descreve uma proposta pedagógica realizada por estudantes de Cálculo Numérico de uma instituição de nível superior do sul do país. A proposta foi desenvolvida segundo os pressupostos teóricos da pesquisa como princípio pedagógico e teve como objetivo identificar a percepção dos estudantes quanto à compreensão do significado de um conceito ao aprenderem como utilizá-lo em um contexto específico de sua vivência acadêmica. Com base nos trabalhos e testemunhos apresentados, e em Wittgenstein, este estudo mostra que as condições de sentido e significado dos conceitos matemáticos abordados em Cálculo Numérico podem ocorrer quando o estudante conhece diferentes usos desses conceitos em seus respectivos cursos de graduação ou futura profissão.Palavras Chave: Cálculo Numérico, Jogos de Linguagem, Pesquisa como Princípio Pedagógico.AbstractThis article presents, in a qualitative approach, a case study in which it describes a pedagogical proposal carried out by students of Numerical Calculus at a higher education institution in the south of the country. The proposal was developed according to the theoretical assumptions of the research as a pedagogical principle and aimed to identify the students' perception regarding the understanding of the meaning of a concept when learning how to use it in a specific context of their academic experience. Based on the works and testimonies presented and on Wittgenstein, it shows that the conditions of sense and meaning of the mathematical concepts covered in Numerical Calculus can occur when the student knows their different uses in their respective undergraduate courses or future profession.Keywords:  Numerical calculus, Language games, Research as a pedagogical principle.ResumenEste artículo presenta, en un enfoque cualitativo, un estudio de caso en el que describe una propuesta pedagógica llevada a cabo por estudiantes de Cálculo Numérico en una institución de educación superior en el sur del país. La propuesta se desarrolló a partir de los supuestos teóricos de la investigación como principio pedagógico y tuvo como objetivo identificar la percepción de los estudiantes sobre la comprensión del significado de un concepto al aprender a utilizarlo en un contexto específico de su experiencia académica. Basado en los trabajos y testimonios presentados y en Wittgenstein, muestra que las condiciones de sentido y significado de los conceptos matemáticos estudiados en el Cálculo Numérico pueden ocurrir cuando el estudiante conoce diferentes usos de estos conceptos en sus respectivos cursos de pregrado o futura profesión.Palabras clave: Cálculo numérico, Juegos de lenguaje, Investigación como principio pedagógico.


2013 ◽  
Vol 41 (11) ◽  
pp. 2334-2348 ◽  
Author(s):  
Michelangelo Paci ◽  
Jari Hyttinen ◽  
Katriina Aalto-Setälä ◽  
Stefano Severi

Author(s):  
Shelby P. Morge ◽  
Mahnaz Moallem ◽  
Chris Gordon ◽  
Gene Tagliarini ◽  
Sridhar Narayan

The Common Core State Standards (CCSS) call for a change in the way mathematics is taught. The mathematical practices outlined by the CCSS call for mathematics as a problem-solving endeavor, rather than routine exercises and practice. A quick Web search can provide mathematics teachers with an abundance of workshops and courses, examples, and videos of the different mathematical practices to help them understand what they mean and look like in practice. However, those examples do not go far in changing the current culture of mathematics instruction. In this chapter, the authors discuss current US mathematics instructional practices and how the CCSS are asking for distinctly different teaching practices. In addition, the authors share how the innovative Using Squeak to Infuse Information Technology Project (USeIT) sidestepped traditional mathematics instructional approaches and utilized problem-solving activities and the development of computational models to support students’ learning of STEM concepts. The authors illustrate how the design, development, and implementation of a Squeak Etoys and Problem-Based Learning (PBL) activity addresses the CCSS expectations for mathematics content, practice for learning, and assessment, and discuss what this means for mathematics teacher education and professional development.


2021 ◽  
Author(s):  
Peter Uhl ◽  
John Lowengrub ◽  
Natalia Komarova ◽  
Dominik Wodarz

Feedback mechanisms within cell lineages are thought to be important for maintaining tissue homeostasis. Mathematical models that assume well-mixed cell populations, together with experimental data, have suggested that negative feedback from differentiated cells on the stem cell self-renewal probability can maintain a stable equilibrium and hence homeostasis. Cell lineage dynamics, however, are characterized by spatial structure, which can lead to different properties. Here, we investigate these dynamics using spatially explicit computational models, including cell division, differentiation, death, and migration / diffusion processes. According to these models, the negative feedback loop on stem cell self-renewal fails to maintain homeostasis, both under the assumption of strong spatial restrictions and fast migration / diffusion. Although homeostasis cannot be maintained, this feedback can regulate cell density and promote the formation of spatial structures in the model. Tissue homeostasis, however, can be achieved if spatially restricted negative feedback on self-renewal is combined with an experimentally documented spatial feedforward loop in which stem cells regulate the fate of transit amplifying cells. This indicates that the dynamics of feedback regulation in tissue cell lineages are more complex than previously thought, and that combinations of spatially explicit control mechanisms are likely instrumental.


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