Effect of Hibiscus rosa sinensis aqueous extract treatment on biochemical parameters in diabetic pregnant rats

Scientific assessment of harmful interactions of chemicals over the entire reproductive cycle are divided into three segments based on the period: from premating and mating to implantation (I), from implantation to major organogenesis (II), and late pregnancy and postnatal development (III). We combined the segments I and II to assessPlathymenia reticulataaqueous extract safety. In order to investigate reproductive toxicity (segment I), pregnant rats received orally 0.5 or 1.0 g/kg of extract, daily, during 18 days. These concentrations were determined by a preliminaryin vitroLD50 test in CHO-k1 cells. A control group received deionized water. The offspring was removed at the 19th day, by caesarean, and a teratology study (segment II) was carried out. The corpora lutea, implants, resorptions, live, and dead fetuses were then counted. Placenta and fetuses were weighted. External and visceral morphology were provided by the fixation of fetuses in Bouin, whereas skeletal analysis was carried out on the diaphanizated ones. The increase in the weights of placenta and fetuses was the only abnormality observed. Since there was no sign of alteration on reproduction parameters at our experimental conditions, we conclude thatP. reticulataaqueous extract is safe at 0.5 to 1.0 g/kg and is not considered teratogenic.

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Effects of Sub-Acute Exposure to Static Magnetic Field on Hematologic and Biochemical Parameters in Pregnant Rats

Electromagnetic Biology and Medicine ◽

10.1080/15368370600860135 ◽

2006 ◽

Vol 25 (3) ◽

pp. 135-144 ◽

Cited By ~ 23

Author(s):

Sihem Chater ◽

Hafedh Abdelmelek ◽

Jean Marc Pequignot ◽

Mohsen Sakly ◽

Khémais Ben Rhouma

Keyword(s):

Magnetic Field ◽

Static Magnetic Field ◽

Biochemical Parameters ◽

Acute Exposure ◽

Pregnant Rats

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Curcuma longa aqueous extract possesses tocolytic potentials

Savannah Veterinary Journal ◽

10.36759/svj.2018.031 ◽

2019 ◽

pp. 1-6

Keyword(s):

Traditional Medicine ◽

Aqueous Extract ◽

Early Pregnancy ◽

Uterine Contraction ◽

Preterm Labour ◽

Curcuma Longa ◽

Organ Bath ◽

Pregnant Rats ◽

Uterine Activity ◽

Uterine Contractions

Introduction: Contraction of the uterus is an important physiological phenomenon that determines the functionality of the uterus for pregnancy and abortion. Curcuma longa, a member of the ginger family (Zingiberracaeae) has been used in traditional medicine because of its various therapeutic properties. Curcuma longa is believed to be beneficial to the female reproductive system by preventing unwanted uterine activity in early pregnancy or treat preterm labour. There are however, no scientific facts verifying the effects on the uterus to support its folklore use as tocolytic agent. The aim of this study was to determine the effects of aqueous extract of Curcuma longa rhizome and its possible mechanism of action on uterine contraction. Methods: The Isolated longitudinal uterine strips were dissected from non-pregnant rats, mounted vertically in an organ bath chamber, and exposed to the aqueous extract of Curcuma longa rhizome at a concentration of 25 - 200 mg/ml. The effects of the extract at a concentration of 50 mg/ml on spontaneous and oxytocin-induced (10 nmol/L) contractions were investigated. Results: The results of the study revealed that the extract significantly (p < 0.05) inhibited both spontaneous and oxytocin-induced uterine contractions (n = 10). The extract also inhibited oxytocin-induced contraction in the absence of exogenous calcium (n = 10). Significance: The result of this research has shown that Curcurma longa extract possesses or exerts tocolytic effect that delays uterine contraction in rats and this finding justify its folklore uses in traditional medicine to prevent unwanted uterine activity in early pregnancy or treat preterm labour.

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