scholarly journals Improving deep learning method for biomedical named entity recognition by using entity definition information

2021 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ying Xiong ◽  
Shuai Chen ◽  
Buzhou Tang ◽  
Qingcai Chen ◽  
Xiaolong Wang ◽  
...  

Abstract Background Biomedical named entity recognition (NER) is a fundamental task of biomedical text mining that finds the boundaries of entity mentions in biomedical text and determines their entity type. To accelerate the development of biomedical NER techniques in Spanish, the PharmaCoNER organizers launched a competition to recognize pharmacological substances, compounds, and proteins. Biomedical NER is usually recognized as a sequence labeling task, and almost all state-of-the-art sequence labeling methods ignore the meaning of different entity types. In this paper, we investigate some methods to introduce the meaning of entity types in deep learning methods for biomedical NER and apply them to the PharmaCoNER 2019 challenge. The meaning of each entity type is represented by its definition information. Material and method We investigate how to use entity definition information in the following two methods: (1) SQuad-style machine reading comprehension (MRC) methods that treat entity definition information as query and biomedical text as context and predict answer spans as entities. (2) Span-level one-pass (SOne) methods that predict entity spans of one type by one type and introduce entity type meaning, which is represented by entity definition information. All models are trained and tested on the PharmaCoNER 2019 corpus, and their performance is evaluated by strict micro-average precision, recall, and F1-score. Results Entity definition information brings improvements to both SQuad-style MRC and SOne methods by about 0.003 in micro-averaged F1-score. The SQuad-style MRC model using entity definition information as query achieves the best performance with a micro-averaged precision of 0.9225, a recall of 0.9050, and an F1-score of 0.9137, respectively. It outperforms the best model of the PharmaCoNER 2019 challenge by 0.0032 in F1-score. Compared with the state-of-the-art model without using manually-crafted features, our model obtains a 1% improvement in F1-score, which is significant. These results indicate that entity definition information is useful for deep learning methods on biomedical NER. Conclusion Our entity definition information enhanced models achieve the state-of-the-art micro-average F1 score of 0.9137, which implies that entity definition information has a positive impact on biomedical NER detection. In the future, we will explore more entity definition information from knowledge graph.

2021 ◽  
Vol 54 (1) ◽  
pp. 1-39
Author(s):  
Zara Nasar ◽  
Syed Waqar Jaffry ◽  
Muhammad Kamran Malik

With the advent of Web 2.0, there exist many online platforms that result in massive textual-data production. With ever-increasing textual data at hand, it is of immense importance to extract information nuggets from this data. One approach towards effective harnessing of this unstructured textual data could be its transformation into structured text. Hence, this study aims to present an overview of approaches that can be applied to extract key insights from textual data in a structured way. For this, Named Entity Recognition and Relation Extraction are being majorly addressed in this review study. The former deals with identification of named entities, and the latter deals with problem of extracting relation between set of entities. This study covers early approaches as well as the developments made up till now using machine learning models. Survey findings conclude that deep-learning-based hybrid and joint models are currently governing the state-of-the-art. It is also observed that annotated benchmark datasets for various textual-data generators such as Twitter and other social forums are not available. This scarcity of dataset has resulted into relatively less progress in these domains. Additionally, the majority of the state-of-the-art techniques are offline and computationally expensive. Last, with increasing focus on deep-learning frameworks, there is need to understand and explain the under-going processes in deep architectures.


2020 ◽  
Author(s):  
Usman Naseem ◽  
Matloob Khushi ◽  
Vinay Reddy ◽  
Sakthivel Rajendran ◽  
Imran Razzak ◽  
...  

Abstract Background: In recent years, with the growing amount of biomedical documents, coupled with advancement in natural language processing algorithms, the research on biomedical named entity recognition (BioNER) has increased exponentially. However, BioNER research is challenging as NER in the biomedical domain are: (i) often restricted due to limited amount of training data, (ii) an entity can refer to multiple types and concepts depending on its context and, (iii) heavy reliance on acronyms that are sub-domain specific. Existing BioNER approaches often neglect these issues and directly adopt the state-of-the-art (SOTA) models trained in general corpora which often yields unsatisfactory results. Results: We propose biomedical ALBERT (A Lite Bidirectional Encoder Representations from Transformers for Biomedical Text Mining) - bioALBERT - an effective domain-specific pre-trained language model trained on huge biomedical corpus designed to capture biomedical context-dependent NER. We adopted self-supervised loss function used in ALBERT that targets on modelling inter-sentence coherence to better learn context-dependent representations and incorporated parameter reduction strategies to minimise memory usage and enhance the training time in BioNER. In our experiments, BioALBERT outperformed comparative SOTA BioNER models on eight biomedical NER benchmark datasets with four different entity types. The performance is increased for; (i) disease type corpora by 7.47% (NCBI-disease) and 10.63% (BC5CDR-disease); (ii) drug-chem type corpora by 4.61% (BC5CDR-Chem) and 3.89 (BC4CHEMD); (iii) gene-protein type corpora by 12.25% (BC2GM) and 6.42% (JNLPBA); and (iv) Species type corpora by 6.19% (LINNAEUS) and 23.71% (Species-800) is observed which leads to a state-of-the-art results. Conclusions: The performance of proposed model on four different biomedical entity types shows that our model is robust and generalizable in recognizing biomedical entities in text. We trained four different variants of BioALBERT models which are available for the research community to be used in future research.


2020 ◽  
Vol 36 (15) ◽  
pp. 4331-4338
Author(s):  
Mei Zuo ◽  
Yang Zhang

Abstract Motivation Named entity recognition is a critical and fundamental task for biomedical text mining. Recently, researchers have focused on exploiting deep neural networks for biomedical named entity recognition (Bio-NER). The performance of deep neural networks on a single dataset mostly depends on data quality and quantity while high-quality data tends to be limited in size. To alleviate task-specific data limitation, some studies explored the multi-task learning (MTL) for Bio-NER and achieved state-of-the-art performance. However, these MTL methods did not make full use of information from various datasets of Bio-NER. The performance of state-of-the-art MTL method was significantly limited by the number of training datasets. Results We propose two dataset-aware MTL approaches for Bio-NER which jointly train all models for numerous Bio-NER datasets, thus each of these models could discriminatively exploit information from all of related training datasets. Both of our two approaches achieve substantially better performance compared with the state-of-the-art MTL method on 14 out of 15 Bio-NER datasets. Furthermore, we implemented our approaches by incorporating Bio-NER and biomedical part-of-speech (POS) tagging datasets. The results verify Bio-NER and POS can significantly enhance one another. Availability and implementation Our source code is available at https://github.com/zmmzGitHub/MTL-BC-LBC-BioNER and all datasets are publicly available at https://github.com/cambridgeltl/MTL-Bioinformatics-2016. Supplementary information Supplementary data are available at Bioinformatics online.


2021 ◽  
Vol 2 (4) ◽  
pp. 1-24
Author(s):  
Pratyay Banerjee ◽  
Kuntal Kumar Pal ◽  
Murthy Devarakonda ◽  
Chitta Baral

In this work, we formulated the named entity recognition (NER) task as a multi-answer knowledge guided question-answer task (KGQA) and showed that the knowledge guidance helps to achieve state-of-the-art results for 11 of 18 biomedical NER datasets. We prepended five different knowledge contexts—entity types, questions, definitions, and examples—to the input text and trained and tested BERT-based neural models on such input sequences from a combined dataset of the 18 different datasets. This novel formulation of the task (a) improved named entity recognition and illustrated the impact of different knowledge contexts, (b) reduced system confusion by limiting prediction to a single entity-class for each input token (i.e., B , I , O only) compared to multiple entity-classes in traditional NER (i.e., B entity 1, B entity 2, I entity 1, I , O ), (c) made detection of nested entities easier, and (d) enabled the models to jointly learn NER-specific features from a large number of datasets. We performed extensive experiments of this KGQA formulation on the biomedical datasets, and through the experiments, we showed when knowledge improved named entity recognition. We analyzed the effect of the task formulation, the impact of the different knowledge contexts, the multi-task aspect of the generic format, and the generalization ability of KGQA. We also probed the model to better understand the key contributors for these improvements.


2021 ◽  
Author(s):  
Pan Liu ◽  
Yanming Guo ◽  
Fenglei Wang ◽  
Guohui Li

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Marco Humbel ◽  
Julianne Nyhan ◽  
Andreas Vlachidis ◽  
Kim Sloan ◽  
Alexandra Ortolja-Baird

PurposeBy mapping-out the capabilities, challenges and limitations of named-entity recognition (NER), this article aims to synthesise the state of the art of NER in the context of the early modern research field and to inform discussions about the kind of resources, methods and directions that may be pursued to enrich the application of the technique going forward.Design/methodology/approachThrough an extensive literature review, this article maps out the current capabilities, challenges and limitations of NER and establishes the state of the art of the technique in the context of the early modern, digitally augmented research field. It also presents a new case study of NER research undertaken by Enlightenment Architectures: Sir Hans Sloane's Catalogues of his Collections (2016–2021), a Leverhulme funded research project and collaboration between the British Museum and University College London, with contributing expertise from the British Library and the Natural History Museum.FindingsCurrently, it is not possible to benchmark the capabilities of NER as applied to documents of the early modern period. The authors also draw attention to the situated nature of authority files, and current conceptualisations of NER, leading them to the conclusion that more robust reporting and critical analysis of NER approaches and findings is required.Research limitations/implicationsThis article examines NER as applied to early modern textual sources, which are mostly studied by Humanists. As addressed in this article, detailed reporting of NER processes and outcomes is not necessarily valued by the disciplines of the Humanities, with the result that it can be difficult to locate relevant data and metrics in project outputs. The authors have tried to mitigate this by contacting projects discussed in this paper directly, to further verify the details they report here.Practical implicationsThe authors suggest that a forum is needed where tools are evaluated according to community standards. Within the wider NER community, the MUC and ConLL corpora are used for such experimental set-ups and are accompanied by a conference series, and may be seen as a useful model for this. The ultimate nature of such a forum must be discussed with the whole research community of the early modern domain.Social implicationsNER is an algorithmic intervention that transforms data according to certain rules-, patterns- or training data and ultimately affects how the authors interpret the results. The creation, use and promotion of algorithmic technologies like NER is not a neutral process, and neither is their output A more critical understanding of the role and impact of NER on early modern documents and research and focalization of some of the data- and human-centric aspects of NER routines that are currently overlooked are called for in this paper.Originality/valueThis article presents a state of the art snapshot of NER, its applications and potential, in the context of early modern research. It also seeks to inform discussions about the kinds of resources, methods and directions that may be pursued to enrich the application of NER going forward. It draws attention to the situated nature of authority files, and current conceptualisations of NER, and concludes that more robust reporting of NER approaches and findings are urgently required. The Appendix sets out a comprehensive summary of digital tools and resources surveyed in this article.


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