scholarly journals Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jinyao Ni ◽  
Junwu Zhang ◽  
Yanxia Chen ◽  
Weizhong Wang ◽  
Jinlin Liu
Keyword(s):  
Information System ◽  
Lichen Planus ◽  
Hospital Information System ◽  
Clinical Characteristics ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
University Hospital ◽  
Ivig Treatment ◽  
Good’S Syndrome ◽  
Laboratory Results

Abstract Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. Methods We used the hospital information system to retrospectively screen thymoma and hypogammaglobulinemia patients at the First Affiliated Hospital of Wenzhou Medical University from Apr 2012 to Apr 2020. The clinical, laboratory, treatment, and outcome data for these patients were collected and analyzed. Results Among the 181 screened thymoma patients, 5 thymoma patients with hypogammaglobulinemia were identified; 3 patients had confirmed diagnoses of GS, and the other 2 did not have a diagnosis of GS recorded in the hospital information system. A retrospective review of the clinical characteristics, laboratory results, and follow-up data for these 2 undiagnosed patients confirmed the diagnosis of GS. All 5 GS patients presented with pneumonia, 2 patients presented with recurrent skin abscesses, 2 patients presented with recurrent cough and expectoration, 1 patient presented with recurrent oral lichen planus and diarrhea, and 1 patient presented with tuberculosis and granulomatous epididymitis. In the years after the diagnosis of hypogammaglobulinemia with mild symptoms, all 5 patients had received irregular intravenous immunoglobulin (IVIG) treatment. As the course of the disease progressed, the clinical symptoms of all patients worsened, but the symptoms were partly resolved with IVIG in these patients. However, 4 patients died due to comorbidities. Conclusion GS should be investigated as a possible diagnosis in thymoma patients who present with hypogammaglobulinemia, especially those with recurrent opportunistic infections, recurrent skin abscesses, chronic diarrhea, or recurrent lichen planus.

Evaluation Study of Different Strategies for Detecting Surgical Site Infections Using the Hospital Information System at Lyon University Hospital, France

2012 ◽  
Vol 255 (5) ◽  
pp. 896-900 ◽  
Author(s):  
Solweig Gerbier-Colomban ◽  
Monique Bourjault ◽  
Jean-Charles Cêtre ◽  
Jacques Baulieux ◽  
Marie-Hélène Metzger
Keyword(s):  
Information System ◽  
Hospital Information System ◽  
Surgical Site Infections ◽  
Evaluation Study ◽  
University Hospital

A Three-Level Graph-Based Model for the Management of Hospital Information Systems

1995 ◽  
Vol 34 (04) ◽  
pp. 378-396 ◽  
Author(s):  
A. Winter ◽  
R. Haux
Keyword(s):  
Information System ◽  
Information Processing ◽  
Information Systems ◽  
Hospital Information System ◽  
Low Cost ◽  
Hospital Information Systems ◽  
University Hospital ◽  
University Hospitals ◽  
Application Systems ◽  
Graph Based Model

Abstract:Information processing in hospitals, especially in university hospitals, is currently faced with two major issues: low-cost hardware and progress in networking technology leads to a further decentralization of computing capacity, due to the increasing need for information processing in hospitals and due to economic restrictions, it is necessary to use, commercial software products. This leads to heterogeneous hospital information systems using a variety of software and hardware products, and to a stronger demand for integrating these products and, in general, for a dedicated methodology for the management of hospital information systems to support patient care and medical research. We present a three-level graph-based model (3LGM) to support the systematic management of hospital information systems. 3LGM can serve as a basis for assessing the quality of information processing in hospitals. 3LGM distinguishes between a procedural level for describing the information procedures (and their information interchange) of a hospital information system and thus its functionality, a logical tool level, focusing on application systems and communication links, and a physical tool level with physical subsystems (e.g., computer systems) and data transmission. The examples that are presented have been taken from the Heidelberg University Hospital Information System.

Role of an Effective Hospital Information System in a Depressed Economy

1997 ◽  
Vol 36 (02) ◽  
pp. 141-143
Author(s):  
J. A. Olabode ◽  
A. A. Osunlaja
Keyword(s):  
Health Care ◽  
Information System ◽  
Hospital Information System ◽  
Care Delivery ◽  
Cost Effective ◽  
Practical Experience ◽  
University Hospital ◽  
Economic Use

Abstract:This work is based on practical experience acquired in the development of a hospital information system in a university hospital in Nigeria. The paper discusses how accurate, adequate and timely medical data can promote economy in health-care delivery in a depressed economy. Existing constraints are identified and solutions offered for an effective hospital information system. An effort has been made to illustrate how the application of informatics technology can be cost effective in the long-term, by ensuring effective and economic use of facilities and resources. Once an effective hospital information is operative, provision of affordable health care in a depressed economy would be feasible. To this end, the need for cooperation between countries to support technology and manpower is emphasized.

Comparing a Japanese and a German Hospital Information System

2009 ◽  
Vol 48 (06) ◽  
pp. 531-539 ◽  
Author(s):  
L. Ißler ◽  
A. Winter ◽  
K. Takabayashi ◽  
F. Jahn
Keyword(s):  
Information System ◽  
Information Systems ◽  
Hospital Information System ◽  
Reference Model ◽  
Quality Criteria ◽  
Hospital Information Systems ◽  
University Hospital ◽  
Structural Quality ◽  
German Hospital ◽  
Cross Cultural Comparison

Summary Objectives: To examine the architectural differences and similarities of a Japanese and German hospital information system (HIS) in a case study. This cross-cultural comparison, which focuses on structural quality characteristics, offers the chance to get new insights into different HIS architectures, which possibly cannot be obtained by inner-country comparisons. Methods: A reference model for the domain layer of hospital information systems containing the typical enterprise functions of a hospital provides the basis of comparison for the two different hospital information systems. 3LGM2 models, which describe the two HISs and which are based on that reference model, are used to assess several structural quality criteria. Four of these criteria are introduced in detail. Results: The two examined HISs are different in terms of the four structural quality criteria examined. Whereas the centralized architecture of the hospital information system at Chiba University Hospital causes only few functional redundancies and leads to a low implementation of communication standards, the hospital information system at the University Hospital of Leipzig, having a decentralized architecture, exhibits more functional redundancies and a higher use of communication standards. Conclusions: Using a model-based comparison, it was possible to detect remarkable differences between the observed hospital information systems of completely different cultural areas. However, the usability of 3LGM2 models for comparisons has to be improved in order to apply key figures and to assess or benchmark the structural quality of health information systems architectures more thoroughly.

scholarly journals A retrospective study of the clinical characteristics of COVID-19 infection in 26 children

2020 ◽  
Author(s):  
Anjue Tang ◽  
Wenhui Xu ◽  
Min Shen ◽  
Peifen Chen ◽  
Guobao Li ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Pediatric Patients ◽  
Clinical Symptoms ◽  
Good Prognosis ◽  
Chest Ct ◽  
Alanine Transaminase ◽  
Laboratory Results ◽  
Pulmonary Infiltration ◽  
Novel Coronavirus ◽  
Chest Ct Scan

ABSTRACTBackgroundThe outbreak of novel coronavirus pneumonia in China began in December 2019. Studies on novel coronavirus disease (COVID-19) were less based on pediatric patients. This study aimed to reveal the clinical characteristics of COVID-19 in children.MethodThis study retrospectively analyzed the clinical symptoms, laboratory results, chest CT, and treatment of children with laboratory-confirmed COVID-19(ie, with samples that were positive for 2019 novel coronavirus[2019-nCoV]) who were admitted to Shenzhen Center of National Infectious Disease Clinical Medical Research from January 16 to February 8, 2020.ResultNine patients had no obvious clinical symptom. 11 patients developed fever. Other symptoms, including cough(in eleven of seventeen patients), rhinorrhea(in two), diarrhea(in two), vomiting(in two), were also observed. A small minority of patients had lymphocytopenia. Alanine transaminase or transaminase increased in three cases. According to chest CT scan, 11 patients showed unilateral pneumonia, 8 patients had no pulmonary infiltration. No serious complications such as acute respiratory syndrome and acute lung injury occurred in all patients.ConclusionThe clinical characteristics of 2019-nCoV infection in children were different from adult. The overall condition of children were mild and have a good prognosis.MainpointCOVID-19 is a kind of new infectious disease.The clinical characteristics of 2019-nCoV infection in children may different from adult. Myocardium likely less affected by 2019-nCoV in children.

scholarly journals Clinical Characteristics Analysis of the “Re-positive” Discharged COVID-19 Pneumonia Patients in Wuhan, China

2020 ◽  
Author(s):  
Shengyang He ◽  
Wenwu Sun ◽  
Kefu Zhou ◽  
Mengyun Hu ◽  
Chun Liu ◽  
...  
Keyword(s):  
Ct Scan ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Chest Ct ◽  
Apache Ii ◽  
Laboratory Results ◽  
Characteristics Analysis ◽  
Positive Rate ◽  
Chest Ct Scan ◽  
Demographic Features

Abstract Background: To analyze the clinical characteristics of the re-positive discharged COVID-19 patients and find markers to distinguish them.Methods：The demographic features, clinical symptoms, laboratory results, comorbidities, co-infections, treatments, illness severities and chest CT scan results of 267 patients were collected during 1st January and 15th February 2020. COVID-19 was diagnosed by RT-PCR. The subsequent clinical symptoms and nucleic acid test results was obtained during the 14 days post-hospitalization quarantine.Results: 30 out of 267 COVID-19 patients were detected re-positive during the post-hospitalization quarantine. Re-positive patients couldn’t be distinguished by demographic features, clinical symptoms, laboratory results, comorbidities, co-infections, treatments, chest CT scan results or subsequent clinical symptoms. However, the re-positive rate were found illness severity correlated, along with APACHE II and CURB-65.Conclusion: Common clinical characteristics arn’t able to distinguish re-positive patients. However, severe and critical cases with high APACHE II and CURB-65 scores are more likely to turn re-positive after discharge.Authors Shengyang He, Wenwu Sun, Kefu Zhou contributed equally to this work.

scholarly journals Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Innocent Lule Segamwenge ◽  
Miriam Kaunanele Bernard
Keyword(s):  
Antiretroviral Therapy ◽  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Characteristics ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
Clinical Chemistry ◽  
Inflammatory Cell Infiltrate ◽  
Fulminant Liver Failure

Objectives. To describe the clinical characteristics of patients presenting with fulminant liver failure after varying periods of exposure to Efavirenz containing antiretroviral medications. Methods. We report a series of 4 patients with human immunodeficiency virus (HIV) infection who were admitted with acute liver failure (ALF) over a 6-month period. All these patients had been treated with a range of Efavirenz containing antiretroviral regimens and were negative for hepatitis A, B, and C infections as well as other opportunistic infections, all were negative for autoimmune hepatitis, and none had evidence of chronic liver disease or use of alcohol or herbal medications. Information on patient clinical characteristics, current antiretroviral regimen, CD4 count, HIV-1 RNA levels, and clinical chemistry parameters was collected. Informed consent was provided. Results. During a 6-month period, four patients without other known risk factors for acute hepatitis presented with symptomatic drug-induced liver injury with varying symptoms and outcomes. The pattern of liver injury was hepatocellular for all the 4 cases. Liver biopsies were done for all the four cases and the results showed a heavy mixed inflammatory cell infiltrate with eosinophils. For three patients withdrawal of Efavirenz from their antiretroviral regimen was sufficient to restore transaminase levels to normal and led to improvement of clinical symptoms. For one patient his clinical course was characterized by fulminant liver failure and fluctuating episodes of hepatic encephalopathy which ultimately resulted in his death. Conclusion. Hepatotoxicity of Efavirenz is not as rare as previously described in the literature and does actually present with fatal outcomes. The key message to note is that frequent monitoring of liver enzymes should be done at initiation of antiretroviral therapy and should continue throughout the treatment period.

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