scholarly journals Proteinuria is independently associated with carotid atherosclerosis: a multicentric study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wencai Jiang ◽  
Meixiang Chen ◽  
Jianyu Huang ◽  
Yu Shang ◽  
Changyu Qin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Goodness Of Fit ◽  
Carotid Atherosclerosis ◽  
Southern China ◽  
Multivariate Logistic Regression Model ◽  
Prediction Ability ◽  
Multicentric Study ◽  
Lemeshow Test ◽  
Traditional Risk Factors ◽  
Asymptomatic Subjects

Abstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January 2016 to September 2020, 13,545 asymptomatic subjects from four centres in southern China underwent dipstick proteinuria testing and carotid atherosclerosis examination. Data on demography and past medical history were collected, and laboratory examinations were performed. The samples consisted of 7405 subjects (4875 males and 2530 females), excluding subjects failing to reach predefined standards and containing enough information. A multivariate logistic regression model was used to adjust the influence of traditional risk factors for atherosclerosis on the results. Results Compared with proteinuria-negative subjects, proteinuria-positive subjects had a higher prevalence rate of carotid atherosclerosis. The differences were statistically significant (22.6% vs. 26.7%, χ2 = 10.03, p = 0.002). After adjusting for common risk factors for atherosclerosis, age, sex, BMI, blood lipids, blood pressure, renal function, hypertensive disease, diabetes mellitus and hyperlipidaemia, proteinuria was an independent risk factor for atherosclerosis (OR = 1.191, 95% CI 1.015–1.398, p = 0.033). The Hosmer–Lemeshow test was used to test the risk prediction model of atherosclerosis, and the results showed that the model has high goodness of fit and strong independent variable prediction ability. Conclusions Proteinuria is independently related to carotid atherosclerosis. With the increase in proteinuria level, the risk of carotid atherosclerotic plaque increases. For patients with positive proteinuria, further examination of atherosclerosis should not be ignored.

Carotid atherosclerosis, intima media thickness and risk factors—an analysis of 1781 asymptomatic subjects in Taiwan

2002 ◽  
Vol 164 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Yu Sun ◽  
Cheng-Huai Lin ◽  
Chien-Jung Lu ◽  
Ping-Keung Yip* ◽  
Rong-Chi Chen
Keyword(s):  
Risk Factors ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Asymptomatic Subjects

scholarly journals Decision Tree Analysis of Traditional Risk Factors of Carotid Atherosclerosis and a Cutpoint-Based Prevention Strategy

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e111769 ◽  
Author(s):  
Guangming Qin ◽  
Laisheng Luo ◽  
Lihong Lv ◽  
Yufei Xiao ◽  
Jiangfeng Tu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Decision Tree ◽  
Carotid Atherosclerosis ◽  
Prevention Strategy ◽  
Decision Tree Analysis ◽  
Tree Analysis ◽  
Traditional Risk Factors

scholarly journals Non traditional risk factors of carotid atherosclerosis in rheumatoid arthritis

2011 ◽  
Vol 33 (3) ◽  
pp. 113-119 ◽  
Author(s):  
Elham Kassem ◽  
Raghda Ghonimy ◽  
Mona Adel ◽  
Gehan El-Sharnoby
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Carotid Atherosclerosis ◽  
Traditional Risk Factors

Predicting 30-day readmission after congenital heart surgery across the lifespan

2020 ◽  
Vol 30 (9) ◽  
pp. 1297-1304
Author(s):  
Ian Everitt ◽  
Trenton Hoffman ◽  
Cheryl Raskind-Hood ◽  
Fred H. Rodriguez ◽  
Carol Hogue ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Length Of Stay ◽  
Congenital Heart ◽  
Goodness Of Fit ◽  
Heart Surgery ◽  
Congenital Heart Surgery ◽  
Multivariate Logistic Regression Model ◽  
Data Repository ◽  
History Of

AbstractIntroduction:Hospital readmission is an important driver of costs among patients with CHD. We assessed predictors of 30-day rehospitalisation following cardiac surgery in CHD patients across the lifespan.Methods:This was a retrospective analysis of 981 patients with CHD who had cardiac surgery between January 2011 and December 2012. A multivariate logistic regression model was used to identify demographic, clinical, and surgical predictors of 30-day readmission. Receiver operating curves derived from multivariate logistic modelling were utilised to discriminate between patients who were readmitted and not-readmitted at 30 days. Model goodness of fit was assessed using the Hosmer–Lemeshow test statistic.Results:Readmission in the 30 days following congenital heart surgery is common (14.0%). Among 981 patients risk factors associated with increased odds of 30-day readmission after congenital heart surgery through multivariate analysis included a history of previous cardiac surgery (p < 0.001), longer post-operative length of stay (p < 0.001), as well as nutritional (p < 0.001), haematologic (p < 0.02), and endocrine (p = 0.04) co-morbidities. Patients who underwent septal defect repair had reduced odds of readmission (p < 0.001), as did children (p = 0.04) and adult (p = 0.005) patients relative to neonates.Conclusion:Risk factors for readmission include a history of cardiac surgery, longer length of stay, and co-morbid conditions. This information may serve to guide efforts to prevent readmission and inform resource allocation in the transition of care to the outpatient setting. This study also demonstrated the feasibility of linking a national subspecialty registry to a clinical and administrative data repository to follow longitudinal outcomes of interest.

Correlation between plasma levels of Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters and carotid atherosclerosis in patients with combined hypertension and cerebral infarction

2019 ◽  
Author(s):  
mingde ji ◽  
xueyan wang ◽  
xiaofei zhu ◽  
wanjian gu ◽  
meng zhuo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Infarction ◽  
Logistic Regression Model ◽  
Carotid Atherosclerosis ◽  
Multivariate Logistic Regression Model ◽  
Multivariate Logistic Regression ◽  
Single Item ◽  
Factors Influencing ◽  
At Iii

Abstract Background: To observe the correlation between Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters and carotid atherosclerosis with combined hypertension and cerebral infarction and evaluate their value in risk determination.Methods: Patients with primary hypertension were selected as subjects and divided into 2 groups based on cerebral infarction: simple hypertension group and hypertension combined with cerebral infarction group. The differences of Lp-PLA2, Hcy, CRP, Lp(a), AT-Ⅲ, and TEG were compared. Spearson correlation and multivariate logistic regression model were used to analyze the correlation. A ROC curve was used to analyse the value of a single item and their combination for the determination of carotid AS risk.Results: The levels of single item and CIMT in the hypertension combined with cerebral infarction group were higher, and the values of R, EPL, and LY30 were lower than corresponding indicators in the simple hypertension group. Furthermore, it was found that Lp-PLA2 and Hcy were risk factors. The AUC for Hcy and Lp-PLA2 for the determination the carotid AS risk were larger. Conclusions: The increase or decrease of Lp-PLA2, Hcy, and TEG were important factors influencing the development of carotid AS with combined hypertension and cerebral infarction. The levels of Lp-PLA2, Hcy, and TEG with combined hypertension and cerebral infarction were significantly different from those with simple hypertension and could be used as independent predictive factors for determining carotid AS risk.

scholarly journals Risk factors for ≥high-grade anal intraepithelial lesions in MSM living with HIV and the response to topical and surgical treatments

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245870
Author(s):  
Carmen Hidalgo-Tenorio ◽  
Carmen Maria García-Martínez ◽  
Juan Pasquau ◽  
Mohamed Omar-Mohamed-Balgahata ◽  
Miguel López-Ruz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Goodness Of Fit ◽  
Hpv Infection ◽  
Incidence Rates ◽  
Response To Treatment ◽  
Multivariate Logistic Regression Model ◽  
Self Administration ◽  
Related Factors ◽  
Anal Squamous Cell Carcinoma ◽  
Living With Hiv

Background The objective of this study in MSM living with HIV was to determine the incidence of HSIL and ASCC, related factors, and the response to treatment. Patients and methods Data were gathered in 405 consecutive HIV-infected MSM (May 2010-December 2018) at baseline and annually on: sexual behavior, anal cytology, and HPV PCR and/or high-resolution anoscopy results. They could choose mucosectomy with electric scalpel (from May 2010) or self-administration of 5% imiquimod 3 times weekly for 16 weeks (from November 2013). A multivariate logistic regression model was developed for ≥HSIL-related factors using a step-wise approach to select variables, with a significance level of 0.05 for entry and 0.10 for exit, applying the Hosmer-Lemeshow test to assess the goodness of fit. Results The study included 405 patients with a mean age of 36.2 years; 56.7% had bachelor´s degree, and 52.8% were smokers. They had a mean of 1 (IQR 1–7) sexual partner in the previous 12 months, median time since HIV diagnosis of 2 years, and mean CD4 nadir of 367.9 cells/uL; 86.7% were receiving ART, the mean CD4 level was 689.6 cells/uL, mean CD4/CD8 ratio was 0.77, and 85.9% of patients were undetectable. Incidence rates were 30.86/1,000 patient-years for ≥high squamous intraepithelial lesion (HSIL) and 81.22/100,000 for anal squamous cell carcinoma (ASCC). The ≥HSIL incidence significantly decreased from 42.9% (9/21) in 2010 to 4.1% (10/254) in 2018 (p = 0.034). ≥HSIL risk factors were infection with HPV 11 (OR 3.81; 95%CI 1.76–8.24), HPV 16 (OR 2.69, 95%CI 1.22–5.99), HPV 18 (OR 2.73, 95%CI 1.01–7.36), HPV 53 (OR 2.97, 95%CI 1.002–8.79); HPV 61 (OR 11.88, 95%CI 3.67–38.53); HPV 68 (OR 2.44, CI 95% 1.03–5.8); low CD4 nadir (OR1.002; 95%CI 1–1.004) and history of AIDS (OR 2.373, CI 95% 1.009–5.577). Among HSIL-positive patients, the response rate was higher after imiquimod than after surgical excision (96.7% vs 73.3%, p = 0.009) and there were fewer re-treatments (2.7% vs 23.4%, p = 0.02) and adverse events (2.7% vs 100%, p = 0.046); none developed ASCC. Conclusions HSIL screening and treatment programs reduce the incidence of HSIL, which is related to chronic HPV infection and poor immunological status. Self-administration of 5% imiquimod as first-line treatment of HSIL is more effective than surgery in HIV+ MSM.

Apolipoprotein(a), Fibrinopeptide A and Carotid Atherosclerosis in Middle-Aged Men

1994 ◽  
Vol 72 (04) ◽  
pp. 563-566 ◽  
Author(s):  
Tuomo Rankinen ◽  
Sari Väisänen ◽  
Michele Mercuri ◽  
Rainer Rauramaa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Fibrinopeptide A ◽  
Carotid Imt ◽  
Apolipoprotein A ◽  
The Difference

SummaryThe association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% Cl 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% Cl 1.73; 2.09)] apo(a) quartile. The difference remained (p=0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.

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